Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
Public ClinicalTrials.gov record NCT06736379. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Study of Intratumoral Injections of VLPONC-01 in Head and Neck Cancer
Study identification
- NCT ID
- NCT06736379
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- VLP Therapeutics
- Industry
- Enrollment
- 41 participants
Conditions and interventions
Conditions
- HNSCC
- Head Neck Cancer
- Head and Neck Cancer
- Head and Neck Cancers- Squamous Cell
- Head and Neck Squamous Cell Cancer
- Oral Cavity
- Oral Cavity Carcinoma
- SCC - Squamous Cell Carcinoma
- SCCHN
- Solid Tumors
- Squamous Cell Carcinoma of the Head and Neck
- Squamous Cell Carcinoma, Head And Neck
- Squamous Cell Head and Neck Carcinoma
Interventions
- Pembrolizumab (KEYTRUDA®) Drug
- VRP-encapsulated saRNA encoding IL-12 (1 x 10^9 viral particles per injection) Biological
- VRP-encapsulated saRNA encoding IL-12 (3 x 10^8 viral particles per injection) Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 12, 2025
- Primary completion
- Dec 29, 2027
- Completion
- Dec 29, 2027
- Last update posted
- Jan 19, 2026
2025 – 2027
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Stanford University | Stanford | California | 34305 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06736379, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 19, 2026 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06736379 live on ClinicalTrials.gov.