A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Public ClinicalTrials.gov record NCT06793397. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Efficacy and Safety, Phase III, Multi-center, Double-Blind, Randomized Controlled Study Comparing 2 Active Doses of CYB003 and Placebo in Eligible Participants With Major Depressive Disorder
Study identification
- NCT ID
- NCT06793397
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Cybin IRL Limited
- Industry
- Enrollment
- 330 participants
Conditions and interventions
Conditions
Interventions
- CYB003 Drug
- Psychological Support Behavioral
Drug · Behavioral
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2025
- Primary completion
- Mar 17, 2027
- Completion
- May 7, 2027
- Last update posted
- Apr 30, 2026
2025 – 2027
United States locations
- U.S. sites
- 32
- U.S. states
- 17
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Psychiatry and Behavioral Neurology | Birmingham | Alabama | 35209 | Recruiting |
| Lighthouse Psychiatry | Gilbert | Arizona | 85234 | Recruiting |
| Pillar Clinical Research - Little Rock | Little Rock | Arkansas | 72204 | Not yet recruiting |
| Behavioral Research Specialists, LLC | Glendale | California | 91206 | Not yet recruiting |
| Sun Valley Research Center | Imperial | California | 92251 | Not yet recruiting |
| CalNeuro Research Group | Los Angeles | California | 90025 | Recruiting |
| ATP Clinical Research | Orange | California | 92866 | Recruiting |
| NRC Research Institute | Orange | California | 92868 | Recruiting |
| Inland Psychiatric Medical Group Inc (IPMG Research) | San Juan Capistrano | California | 92675 | Not yet recruiting |
| Psychedelic Science Institute | Santa Monica | California | 90404 | Recruiting |
| Stanford University | Stanford | California | 94305 | Not yet recruiting |
| Yale School of Medicine - Yale Program for Psychedelic Science | New Haven | Connecticut | 06511 | Recruiting |
| CNS Healthcare | Jacksonville | Florida | 32256 | Recruiting |
| Accel Research Sites - Maitland | Maitland | Florida | 32751 | Recruiting |
| Aqualane Clinical Research | Naples | Florida | 34105 | Recruiting |
| Emory University Dept of Psychiatry and Behavioral Studies | Atlanta | Georgia | 30329 | Not yet recruiting |
| Psych Atlanta | Marietta | Georgia | 30060 | Recruiting |
| Rush University | Chicago | Illinois | 60612 | Recruiting |
| Tandem Clinical Research | Marrero | Louisiana | 70006 | Not yet recruiting |
| Johns Hopkins Medicine | Baltimore | Maryland | 21224 | Not yet recruiting |
| Institute for Integrative Therapies | Eden Prairie | Minnesota | 55347 | Recruiting |
| Bio Behavioral Health | Toms River | New Jersey | 08755 | Recruiting |
| New York State Psychiatric Institute | New York | New York | 10032 | Not yet recruiting |
| SP Research PLLC | Oklahoma City | Oklahoma | 73112 | Not yet recruiting |
| Adams Clinical Philadelphia | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Flourish Research Philadelphia | Philadelphia | Pennsylvania | 19462 | Recruiting |
| Austin Clinical Trial Partners | Austin | Texas | 78737 | Not yet recruiting |
| North Texas Clinical Trials | Fort Worth | Texas | 76104 | Not yet recruiting |
| Brain Health Consultants and TMS Center | Houston | Texas | 77046 | Recruiting |
| Flourish Research San Antonio | San Antonio | Texas | 78229 | Recruiting |
| Core Clinical Research | Everett | Washington | 98201 | Not yet recruiting |
| Seattle Neuropsychiatric Treatment Center | Seattle | Washington | 98104 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 35 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06793397, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06793397 live on ClinicalTrials.gov.