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Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

ClinicalTrials.gov public records Last synced May 21, 2026, 2:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials
731
Shown on this page
12
Local recruiting
133
Local phase groups
6
The trial list below is retrieved from the live ClinicalTrials.gov search API for Depression. Results on this page are currently sorted by Recently updated.

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Showing 1–12 of 731 matching trials for Depression.
Indexed local directory records.

Phase distribution

Not applicable 445
Phase 2 79
Phase 4 67
Phase 3 48
Phase 1 32
Early Phase 1 10

Top locations

Boston, Massachusetts 71 New York, New York 69 Pittsburgh, Pennsylvania 49 Houston, Texas 38 Los Angeles, California 36 Chicago, Illinois 35

Top sponsors

Massachusetts General Hospital 33 University of Pittsburgh 28 VA Office of Research and Development 19 University of California, Los Angeles 18 National Institute of Mental Health (NIMH) 17 Washington University School of Medicine 15

Top therapies

Ketamine 15 Sertraline 14 Escitalopram 11 Fluoxetine 9 Psilocybin 9 study of socioeconomic and demographic variables 8

Indexed official records

Open in full search
Recruiting Not applicable Interventional

Implementing Depression and Adherence Treatment

NCT07032363
View directory record Official record
Conditions
AIDS, Adherence, Treatment, Depression, HIV
Interventions
Core Implementation Strategies, Enhanced Implementation Strategies
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
Miami, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced May 20, 2026, 7:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Storytelling and Mindfulness for Graduate Student Wellbeing

NCT05826860
View directory record Official record
Conditions
Anxiety, Burnout, Student, Depression
Interventions
Mindfulness Practice, Storytelling Workshop
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced May 21, 2026, 2:23 AM EDT
Recruiting Not applicable Interventional

Assessing Improvements in Mood and Sleep Trial

NCT06639477
View directory record Official record
Conditions
Depression, Sleep, Suicidality
Interventions
Active Comparator, Active Condition, Treatment As Usual
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
55 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
3
States / cities
Los Angeles, California • Augusta, Georgia • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 20, 2026, 1:31 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Cognitive and Affective Processes Online

NCT05736471
View directory record Official record
Conditions
Depression
Interventions
Computational dissociation of the causes of cognitive rigidity in depression
Diagnostic Test
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 19, 2026, 10:53 AM EDT
Recruiting Phase 3 Interventional

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

NCT04777357
View directory record Official record
Conditions
Bipolar I Disorder, Depression
Interventions
Cariprazine, Placebo
Drug
Lead sponsor
AbbVie
Industry
Eligibility
10 Years to 17 Years
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
69
States / cities
Bentonville, Arkansas • Anaheim, California • Beverly Hills, California + 54 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 20, 2026, 11:39 AM EDT
Recruiting Not applicable Interventional

IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

NCT06582784
View directory record Official record
Conditions
Cancer, Depression, Depressive Symptoms
Interventions
Behavioral Activation Therapy App, Treatment as Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
279 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced May 20, 2026, 10:46 AM EDT
Recruiting Phase 1 Interventional

Pharmacologic Augmentation of TMS for Depression With D-serine

NCT06876129
View directory record Official record
Conditions
Depression
Interventions
D-serine, Placebo, TMS
Drug · Other · Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced May 18, 2026, 5:22 AM EDT
Recruiting Phase 3 Interventional

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

NCT06793397
View directory record Official record
Conditions
Depression, Depression - Major Depressive Disorder, Depression Disorder, Depression Disorders, Depression in Adults, Major Depressive Disorder (MDD)
Interventions
CYB003, Psychological Support
Drug · Behavioral
Lead sponsor
Cybin IRL Limited
Industry
Eligibility
18 Years to 85 Years
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
32
States / cities
Birmingham, Alabama • Gilbert, Arizona • Little Rock, Arkansas + 27 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced May 19, 2026, 10:08 AM EDT
Recruiting Not applicable Interventional

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

NCT06238700
View directory record Official record
Conditions
Depression
Interventions
placebo, pregnenolone
Other · Dietary Supplement
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced May 20, 2026, 8:09 AM EDT
Recruiting Not applicable Interventional

ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

NCT07360600
View directory record Official record
Conditions
Children With Disabilities, Depression, Parents, Stress
Interventions
ACT Together
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced May 21, 2026, 12:34 AM EDT
Recruiting Not applicable Interventional

Families With Pride ("Familias Con Orgullo").

NCT06057337
View directory record Official record
Conditions
Depression, Drug Use
Interventions
Families with Pride ("Familias con Orgullo")
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 19 Years
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced May 19, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional

A Precision Medicine Approach to Target Engagement for Emotion Regulation

NCT05651295
View directory record Official record
Conditions
Anxiety, Borderline Personality Disorder, Depression, Eating Disorders, Emotional Regulation, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder
Interventions
Checking the Facts, Mindfulness of Current Emotions, Opposite to Emotion Action
Behavioral
Lead sponsor
Matthew Southward, PhD
Other
Eligibility
18 Years and older
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced May 21, 2026, 1:01 AM EDT

About this Depression clinical trials directory page

What this page lists
U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Depression.