- Conditions
- Perinatal Mental Health, Fathers, Stress Management
- Interventions
- Fathers and Babies Program, Mothers and Babies Program
- Behavioral
- Lead sponsor
- Northwestern University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 624 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
Condition Directory
Depression clinical trials
Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.
By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 25, 2026 Report an issue
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official matching trials
5328
Shown on this page
12
Local recruiting
226
Local phase groups
6
These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.
How Depression studies are organized in the registry
Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.
- 69% of the 329 locally indexed Depression records are currently marked recruiting.
- The most common phase group in the local index is Not applicable (220 records).
- The most frequent sponsor is Massachusetts General Hospital (17 records).
- The most listed study location is New York, New York (26 records).
Terms that often appear in related listings
These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.
Showing 1–12 of 5,328 matching trials for Depression.
Live ClinicalTrials.gov results.
Phase distribution
Not applicable 220
Phase 2 43
Phase 1 14
Phase 3 9
Phase 4 8
Early Phase 1 6
Top locations
Top sponsors
Top therapies
Live official records
Open in full search- Conditions
- Inflammation, Depression Disorder, Mindfulness, Emotional Well-being, Physical Health, Mental Health
- Interventions
- Mindfulness-based cognitive therapy for perinatal depression, Pregnancy Health Group
- Behavioral
- Lead sponsor
- Oregon Health and Science University
- Other
- Eligibility
- 18 Years to 50 Years · Female only
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2030
- U.S. locations
- 1
- States / cities
- Portland, Oregon
- Conditions
- Major Depression
- Interventions
- Psilocybin
- Drug
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 240 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2031
- U.S. locations
- 5
- States / cities
- Birmingham, Alabama • Tuscaloosa, Alabama • Portland, Oregon + 2 more
- Conditions
- Depression and/or Anxiety Symptoms, Problematic Phone Use Behavior
- Interventions
- Mindwire
- Behavioral
- Lead sponsor
- Brown University
- Other
- Eligibility
- 13 Years to 19 Years
- Enrollment
- 40 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Solid Tumor, Solid Tumor, Adult
- Interventions
- DESCANSO/Depresión/Depressed Mood, Cansancio/Fatigue, and Sueño/Sleep; Rest in English
- Behavioral
- Lead sponsor
- Ponce Medical School Foundation, Inc.
- Industry
- Eligibility
- 21 Years to 100 Years
- Enrollment
- 125 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2025 – 2030
- U.S. locations
- 7
- States / cities
- Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
- Conditions
- Doula Support, Postpartum, Postpartum Depression (PPD), Postpartum Anemia
- Interventions
- Doula-delivered, Nurse-coordinated postpartum support
- Behavioral
- Lead sponsor
- University of South Carolina
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 350 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2030
- U.S. locations
- 1
- States / cities
- Columbia, South Carolina
- Conditions
- Major Depressive Disorder
- Interventions
- Placebo, DT120
- Other · Drug
- Lead sponsor
- Definium Therapeutics US, Inc.
- Industry
- Eligibility
- 18 Years to 74 Years
- Enrollment
- 165 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 30
- States / cities
- Little Rock, Arkansas • Orange, California • San Diego, California + 25 more
- Conditions
- Depression
- Interventions
- Cognitive behavioral therapy plus social cognitive training (CBTSCT)
- Behavioral
- Lead sponsor
- Vanderbilt University
- Other
- Eligibility
- 13 Years to 17 Years
- Enrollment
- 82 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2027
- U.S. locations
- 1
- States / cities
- Nashville, Tennessee
- Conditions
- Treatment Resistant Depression, Substance Use Disorders
- Interventions
- Psilocybin
- Drug
- Lead sponsor
- Indiana University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2027 – 2031
- U.S. locations
- 2
- States / cities
- Indianapolis, Indiana
- Conditions
- Nursing Home Resident, Skilled Nursing Facility, Depression, Feasibility Studies, Caregiver
- Interventions
- Interventions for Stressful Transitions in Later Life (InSTILL)
- Behavioral
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder, MDD
- Interventions
- Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham
- Procedure
- Lead sponsor
- Children's Hospital Medical Center, Cincinnati
- Other
- Eligibility
- 13 Years to 26 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2026
- U.S. locations
- 1
- States / cities
- Cincinnati, Ohio
- Conditions
- Major Depression, Generalized Anxiety, Emotions
- Interventions
- Academic Performance Feedback
- Behavioral
- Lead sponsor
- University of Miami
- Other
- Eligibility
- 18 Years to 35 Years
- Enrollment
- 144 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2030
- U.S. locations
- 1
- States / cities
- Coral Gables, Florida
About this Depression clinical trials directory page
- What this page lists
- U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
- How to narrow results
- Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
- Where the data comes from
- Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.
Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Depression.