A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
Public ClinicalTrials.gov record NCT07400653. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY-BIASED ULTRA LONG-ACTING GLP-1RA, IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study is to learn about the safety and effects of the study medicine to help adults with obesity or overweight and type 2 diabetes lose weight. Being overweight or obese means carrying too much body weight. Type 2 diabetes is a condition where there is too much sugar in the blood. The study medicine is given by a shot under the skin in the belly area. The participants will be trained to do this at home once every week. About 660 out of 1000 adults will also receive the study medicine and about 330 out of 1000 adults will receive placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help us assess if the study medicine is safe and effective. People will take part in this study for about 21 months. During this time, they will have about 14 study visits at the site and 5 over the phone.
Study identification
- NCT ID
- NCT07400653
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,078 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 24, 2026 (Actual)
- Primary completion
- Oct 12, 2027 (Estimated)
- Completion
- May 16, 2028 (Estimated)
- Last update posted
- Oct 13, 2026
2026 – 2028
United States locations
- U.S. sites
- 55
- U.S. states
- 14
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| CenExel Anaheim Clinical Trials | Anaheim | California | 92801 | — |
| Alliance Research Institute | Canoga Park | California | 91304 | — |
| Core Healthcare Group | Cerritos | California | 90703 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| CenExel CNS - Collaborative Neuroscience Research | Los Alamitos | California | 90720 | — |
| DexaFit Los Alamitos | Los Alamitos | California | 90720 | — |
| Retina Consultants of Orange County | Los Alamitos | California | 90720 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Cure Clinical Research | Orange | California | 92866 | — |
| Rolling Oaks Radiology -Palms | Oxnard | California | 93036 | — |
| Clinical Innovations, Inc dba CITrials | Riverside | California | 92506 | — |
| Lundquist Institute for Biomedical Innovation at Harbor- UCLA Medical Center | Torrance | California | 90502 | — |
| Access Eye Institute | Westlake Village | California | 91361 | — |
| CenExcel Rocky Mountain Clinical Research, LLC | Englewood | Colorado | 80113 | — |
| CenExel Denver CO (Rocky Mountain Clinical Research) | Englewood | Colorado | 80113 | — |
| Neuro-Sight Vision Care | Lakewood | Colorado | 80226 | — |
| AMR Clinical | Fort Myers | Florida | 33912 | — |
| Pedro P. Ylisastigui, MD | Fort Myers | Florida | 33912 | — |
| Private Practice Adjacent to For Eyes Optical | Hialeah | Florida | 33014 | — |
| Miami Eye Institute | Hollywood | Florida | 33024 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| Future Medical Research (Civia Health) | Longwood | Florida | 32750 | — |
| Advanced Clinical Research | Miami | Florida | 33156 | — |
| Indago Research & Health Center, Inc | Miami Lakes | Florida | 33016 | — |
| Optimal Research Sites, LLC | Orange City | Florida | 32763 | — |
| Oviedo Medical Research | Oviedo | Florida | 32765 | — |
| CenExel FCR - ForCare Clinical Research | Tampa | Florida | 33613 | — |
| DelRicht Research | Atlanta | Georgia | 30329 | — |
| CenExel iResearch, LLC | Decatur | Georgia | 30030 | — |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | — |
| Patient First Clinical Trials (PFCTRIALS) | Lutherville | Maryland | 21093 | — |
| DelRicht Research | Springfield | Missouri | 65807 | — |
| Upgrade Performance Institute | Elkhorn | Nebraska | 68022 | — |
| Quality Clinical Research Inc | Omaha | Nebraska | 68114 | — |
| Eye Consultants PC | Omaha | Nebraska | 68124 | — |
| Primary clinical Research | Papillion | Nebraska | 68046 | — |
| Hassman Research Institute | Marlton | New Jersey | 08053 | — |
| Forum Health_Cary (Civia) | Cary | North Carolina | 27511 | — |
| Eximia EquiHealth Research | Durham | North Carolina | 27704 | — |
| Sahana Optometry PLLC dba Family Eye Wellness | Holly Springs | North Carolina | 27540 | — |
| Burke Primary Care | Morganton | North Carolina | 28655 | — |
| Eximia Research - NC, LLC | Raleigh | North Carolina | 27607 | — |
| Tribe Clinical Research LLC.- Greenville | Greenville | South Carolina | 29607 | — |
| Tribe Clinical Research LLC. - Spartanburg | Spartanburg | South Carolina | 29301 | — |
| Civia Health Goodlettsville | Goodlettsville | Tennessee | 37072 | — |
| Civia Health Nashville | La Vergne | Tennessee | 37086 | — |
| Amarillo Medical Specialists LLP | Amarillo | Texas | 79124 | — |
| Forum Austin (Civia Health) | Austin | Texas | 78578 | — |
| GLRI El Paso Research | El Paso | Texas | 79936 | — |
| Cardiovascular Specialists of Willowbrook | Houston | Texas | 77070 | — |
| Dallas Clinical Research Center (Pillar Clinical Research) | Richardson | Texas | 75080 | — |
| Pantheon Clinical Research | Bountiful | Utah | 84010 | — |
| CenExel Salt Lake City UT (JBR Clinical Research) | Salt Lake City | Utah | 84107 | — |
| Murray Vision Center PC | Salt Lake City | Utah | 84107 | — |
| ERA Health Research | Redmond | Washington | 98052 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 125 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07400653, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07400653 live on ClinicalTrials.gov.