A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
Public ClinicalTrials.gov record NCT07400653. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY-BIASED ULTRA LONG-ACTING GLP-1RA, IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5)
Study identification
- NCT ID
- NCT07400653
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 999 participants
Conditions and interventions
Interventions
- PF-08653944 Drug
- Placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 23, 2026
- Primary completion
- Oct 11, 2027
- Completion
- May 15, 2028
- Last update posted
- Apr 19, 2026
2026 – 2028
United States locations
- U.S. sites
- 35
- U.S. states
- 12
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| CenExel Anaheim Clinical Trials | Anaheim | California | 92801 | Recruiting |
| Alliance Research Institute | Canoga Park | California | 91304 | Recruiting |
| Core Healthcare Group | Cerritos | California | 90703 | Recruiting |
| CenExel CNS - Collaborative Neuroscience Research | Los Alamitos | California | 90720 | Recruiting |
| Cure Clinical Research | Orange | California | 92866 | Recruiting |
| CenExel CIT | Riverside | California | 92506 | Recruiting |
| CenExel Denver CO (Rocky Mountain Clinical Research) | Englewood | Colorado | 80113 | Recruiting |
| Miami Eye Institute | Hollywood | Florida | 33024 | Recruiting |
| Research Centers of America | Hollywood | Florida | 33024 | Recruiting |
| Future Medical Research (Civia Health) | Longwood | Florida | 32750 | Recruiting |
| Advanced Clinical Research | Miami | Florida | 33156 | Recruiting |
| Oviedo Medical Research | Oviedo | Florida | 32765 | Recruiting |
| CenExel FCR - ForCare Clinical Research | Tampa | Florida | 33613 | Recruiting |
| DelRicht Research | Atlanta | Georgia | 30329 | Recruiting |
| CenExel iResearch, LLC | Decatur | Georgia | 30030 | Recruiting |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | Recruiting |
| Patient First Clinical Trials (PFCTRIALS) | Lutherville | Maryland | 21093 | Recruiting |
| Civia Health St. Louis | Creve Coeur | Missouri | 63141 | Not yet recruiting |
| Civia Health Independence | Independence | Missouri | 64055 | Not yet recruiting |
| DelRicht Research @ Command Family Medicine | Springfield | Missouri | 65807 | Recruiting |
| Quality Clinical Research Inc | Omaha | Nebraska | 68114 | Recruiting |
| Primary Care Research (Civia Health) | Papillion | Nebraska | 68046 | Recruiting |
| CenExel HRI - Hassman Research Institute | Marlton | New Jersey | 08053 | Recruiting |
| Forum Health Cary | Cary | North Carolina | 27511 | Recruiting |
| Eximia EquiHealth Research | Durham | North Carolina | 27704 | Recruiting |
| Eximia Research - NC, LLC | Raleigh | North Carolina | 27607 | Recruiting |
| Civia Health Goodlettsville | Goodlettsville | Tennessee | 37072 | Not yet recruiting |
| Civia Health Nashville | La Vergne | Tennessee | 37086 | Not yet recruiting |
| Civia Health Memphis | Memphis | Tennessee | 38117 | Not yet recruiting |
| Forum Austin (Civia Health) | Austin | Texas | 78578 | Recruiting |
| GLRI El Paso Research | El Paso | Texas | 79936 | Recruiting |
| Dallas Clinical Research Center (Pillar Clinical Research) | Richardson | Texas | 75080 | Recruiting |
| Pantheon Clinical Research | Bountiful | Utah | 84010 | Recruiting |
| CenExel Salt Lake City UT (JBR Clinical Research) | Salt Lake City | Utah | 84107 | Recruiting |
| Murray Vision Center PC | Salt Lake City | Utah | 84107 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 149 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07400653, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced May 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07400653 live on ClinicalTrials.gov.