Condition Directory

Heart Failure clinical trials

Directory of U.S. ClinicalTrials.gov public records for Heart Failure. Browse Heart Failure recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 2:30 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Heart Failure studies are organized in the registry

Heart failure records routinely distinguish reduced versus preserved ejection fraction — the abbreviations HFrEF and HFpEF appear directly in titles and condition fields and are the cleanest way to split the portfolio. Device and monitoring studies form a substantial share alongside drug trials.

Terms that often appear in related listings

HFrEF HFpEF preserved ejection fraction cardiomyopathy

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 457–468 of 2,566 matching trials for Heart Failure.

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Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

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Conditions: Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
Interventions: Losartan, Radiation Therapy; Drug · Radiation
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Type2 Diabetes, Heart Failure With Preserved Ejection Fraction
Interventions: Empagliflozin 25 MG, Placebo; Drug
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Heart Failure
Interventions: CardioMEMS HF System; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Timeline: 2025 – 2032
U.S. locations: 1
States / cities: Pleasanton, California

Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: TVS, SHAM; Device
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 85 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Acute on Chronic Systolic Congestive Heart Failure, Cardiorenal Syndrome
Interventions: Selective Cytopheretic Device; Device
Lead sponsor: SeaStar Medical; Industry
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Heart Failure, Cardiac Imaging Techniques, Congenital Heart Defects
Interventions: Not listed
Lead sponsor: Children's National Research Institute; Other
Eligibility: 6 Months and older
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Heart Failure, Fluid Overload
Interventions: SCP-111, Furosemide USP; Drug
Lead sponsor: scPharmaceuticals, Inc.; Industry
Eligibility: 45 Years to 80 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Breast Carcinoma
Interventions: Laboratory Biomarker Analysis; Other
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: Not listed
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2100
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Heart Failure
Interventions: EVAHEART Left Ventricular Assist System (LVAS), HeartMate 3; Device
Lead sponsor: Evaheart, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 12
States / cities: Gainesville, Florida • Tampa, Florida • Indianapolis, Indiana + 9 more

Conditions: Atrial Fibrillation, Heart Failure With Normal Ejection Fraction
Interventions: Pulmonary Vein Isolation; Procedure
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years to 90 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Heart Failure
Interventions: sacubitril/valsartan; Drug
Lead sponsor: Methodist Health System; Other
Eligibility: 18 Years and older
Enrollment: 6,558 participants
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Heart Failure
Interventions: Artificial intelligence speech-to-text tool; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

About this Heart Failure clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Heart Failure as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Heart Failure.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Heart Failure clinical trials

How Heart Failure studies are organized in the registry

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Live official records

Losartan in Prevention of Radiation-Induced Heart Failure

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

CardioMEMS HF System Coverage With Evidence Development Study

Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure

Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD

MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients

Pharmacokinetics and Pharmacodynamics of Subcutaneous vs Intravenous Furosemide in Healthy Volunteers

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System

Ablation Versus Medical Management of Atrial Fibrillation in HFpEF

Efficacy and Safety of Sacubitril/Valsartan in African American Patients With Heart Failure With Reduced Ejection Fraction

Speech-to-text Tool for Heart Failure Patient-Reported Data

About this Heart Failure clinical trials directory page