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Mild Cognitive Impairment clinical trials

Directory of U.S. ClinicalTrials.gov public records for Mild Cognitive Impairment. Browse Mild Cognitive Impairment recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 31, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 31, 2026, 8:38 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials
844
Shown on this page
12
Current sort
Recently updated
Condition scope
Mild Cognitive Impairment
Additional filters apply within this condition.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

How Mild Cognitive Impairment studies are organized in the registry

MCI is the registry’s main gateway term for early-stage memory and Alzheimer’s-prevention research; “amnestic MCI” labels the memory-specific subset. The portfolio includes a high share of observational cohort studies from memory clinics, so the study-type filter cleanly separates those from interventional trials.

Terms that often appear in related listings

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

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These controls apply only within Mild Cognitive Impairment. Default order is Recently updated. Add location, sponsor, treatment, or recruitment status to narrow this condition page further.

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Showing 205–216 of 844 matching trials for Mild Cognitive Impairment.
Live ClinicalTrials.gov results.
Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

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Recruiting Phase 1 Interventional Accepts healthy volunteers

ACT for Individuals With MNCD and Their Care Partners

NCT07239609
Conditions
Depression in Adults, Anxiety Disorder Generalized, Grief
Interventions
Acceptance Commitment Therapy
Behavioral
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lubbock, Texas
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Physical Activity With Cognitive Impairment

NCT05370118
Conditions
Mild Cognitive Impairment, Caregiver Burnout
Interventions
Telerehabilitation physical activity behavioral (TPAB) intervention
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
50 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Omaha, Nebraska
Conditions
Mild Cognitive Impairment
Interventions
Progressive aerobic exercise, Adaptive cognitive training, Combined
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Type2diabetes, Mild Cognitive Impairment, Age-related Cognitive Decline
Interventions
Progressive Exercise Program (12 Weeks)
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
55 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Galveston, Texas
Recruiting Not applicable Interventional Accepts healthy volunteers

Wayfinding Intervention and Long-Term Memory

NCT05625425
Conditions
Long-Term Memory Decline, Mild Cognitive Impairment
Interventions
LabyrinthVR software, Placebo Games software, Labyrinth Tablet software, Labyrinth VR wireless
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Lighting Intervention
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
50 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Albany, New York • New York, New York
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Virtual Music Therapy
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

NCT06538311
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Logopenic Progressive Aphasia, Amnestic Symptoms
Interventions
Active rTMS, Sham rTMS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Mild Cognitive Impairment, Dementia, BPSD, BPSD (Behavioral and Psychological Symptoms of Dementia), Reminiscence Therapy
Interventions
Smart Virtual Reminiscence Therapy, Music Therapy
Device · Other
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

NCT07044596
Conditions
Mild Traumatic Brain Injury, Post Concussion Syndrome
Interventions
Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI), MAGNUS scanner
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
20 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Recruiting Not applicable Interventional

δ in Dementia Clinical Trials

NCT05592678
Conditions
Alzheimer's Disease (AD), Dementia, Cognitive Decline, Mild Cognitivie Impairment (MCI)
Interventions
Donepezil
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
65 Years to 100 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Recruiting Not applicable Interventional Accepts healthy volunteers

A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

NCT05877196
Conditions
Mild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive Decline, Memory Loss, Memory Impairment
Interventions
Moderate Intensity Continuous Training (MICT), Chair-based Stretch, High-Intensity Interval Training (HIIT), Combined Aerobic Resistance Exercise (CARE)
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
65 Years and older
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Phoenix, Arizona

About this Mild Cognitive Impairment clinical trials directory page

What this page lists
U.S. ClinicalTrials.gov public records that list Mild Cognitive Impairment as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Mild Cognitive Impairment.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Mild Cognitive Impairment.