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Mild Cognitive Impairment clinical trials

Directory of U.S. ClinicalTrials.gov public records for Mild Cognitive Impairment. Browse Mild Cognitive Impairment recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced November 7, 2026 Report an issue

ClinicalTrials.gov public records Last synced Nov 7, 2026, 7:17 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials
845
Shown on this page
12
Current sort
Recently updated
Condition scope
Mild Cognitive Impairment
Additional filters apply within this condition.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

How Mild Cognitive Impairment studies are organized in the registry

MCI is the registry’s main gateway term for early-stage memory and Alzheimer’s-prevention research; “amnestic MCI” labels the memory-specific subset. The portfolio includes a high share of observational cohort studies from memory clinics, so the study-type filter cleanly separates those from interventional trials.

Terms that often appear in related listings
amnestic MCI early Alzheimer memory cognitive training

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

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These controls apply only within Mild Cognitive Impairment. Default order is Recently updated. Add location, sponsor, treatment, or recruitment status to narrow this condition page further.

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Showing 709–720 of 845 matching trials for Mild Cognitive Impairment.
Live ClinicalTrials.gov results.
Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

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Withdrawn No phase listed Observational Accepts healthy volunteers

Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel

NCT01891383
View directory record Official record
Conditions
Dementia, Traumatic Brain Injury (TBI), Mild Cognitive Impairment (MCI), Chronic Traumatic Encephalopathy (CTE), Post-traumatic Stress Disorder (PTSD)
Interventions
Not listed
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
50 Years to 95 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
2
States / cities
Yountville, California • Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 18, 2019 · Synced Nov 7, 2026, 7:17 AM EST
Completed Phase 3 Interventional Results available

Preventing Cognitive Decline in African Americans With Mild Cognitive Impairment

NCT01299766
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Behavioral Activation (BA), Supportive Therapy (ST)
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
65 Years and older
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Imaging Tau in Alzheimer's Disease and Normal Aging

NCT02884492
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
18F-THK-5351, Lumbar Puncture (optional)
Drug · Procedure
Lead sponsor
William Charles Kreisl
Other
Eligibility
50 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Completed Not applicable Interventional Results available

Risk Evaluation and Education for Alzheimer's Disease (REVEAL) IV

NCT01434667
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
APOE genotype and Alzheimer's disease risk disclosure, Alzheimer's disease risk disclosure
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Ann Arbor, Michigan • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Completed Phase 4 Interventional

The Use of Duloxetine for Cognition Improvement in Individuals With Mild Cognitive Impairment

NCT02590874
View directory record Official record
Conditions
Mild Cognitive Impairment, Depression
Interventions
Duloxetine, Placebo
Drug
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
50 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Not listed Not applicable Interventional

Evaluating a Digital Memory Notebook App to Improve Functional Independence

NCT03453554
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Digital Notebook app, Smart Home Prompting
Other
Lead sponsor
Washington State University
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Specialized Food Plan Based on Individual Physiological Comprehensive Body Assessments Accompanied With Cellular Repair Therapy to Decrease Inflammation Cognitively Impaired Patients

NCT03630419
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Mito-Food Plan, Cellular Repair Therapy
Dietary Supplement · Other
Lead sponsor
Perseverance Research Center, LLC
Other
Eligibility
55 Years to 90 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Biomarker Levels as A Predictor of Concussion Severity OUTcomes (BlacOut)

NCT02992327
View directory record Official record
Conditions
Concussion, Mild, Neurocognitive Dysfunction
Interventions
Not listed
Lead sponsor
HealthPartners Institute
Other
Eligibility
8 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 7, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation

NCT01958437
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 88 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Decatur, Georgia • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Not listed No phase listed Observational

Evidence Amyloid Scan EEG Study

NCT03644043
View directory record Official record
Conditions
Alzheimer Disease, Dementia Frontal, Mild Cognitive Impairment
Interventions
EEG scan
Device
Lead sponsor
Metabolic Therapy Inc.
Other
Eligibility
60 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Not listed Phase 1 Interventional Accepts healthy volunteers

Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations

NCT02928211
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Sapphire II, Aftobetin-HCl, Positron Emission Tomography
Device · Drug · Radiation
Lead sponsor
Cognoptix, Inc.
Industry
Eligibility
25 Years to 90 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 22, 2018 · Synced Nov 7, 2026, 7:17 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Piedmont Aging, Cognition & Exercise Study-2

NCT02312843
View directory record Official record
Conditions
Mild Cognitive Impairment, Prediabetes
Interventions
Exercise/Aerobic, Exercise/Stretching
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
50 Years to 89 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Nov 7, 2026, 7:17 AM EST

About this Mild Cognitive Impairment clinical trials directory page

What this page lists
U.S. ClinicalTrials.gov public records that list Mild Cognitive Impairment as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results
Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Mild Cognitive Impairment.
Where the data comes from
Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Mild Cognitive Impairment.