Healthy Volunteer Hub

Healthy volunteer clinical trials in the U.S.

This page focuses on public ClinicalTrials.gov records that explicitly say they accept healthy volunteers. It starts with recruiting studies by default, and it does not guess the visitor's location. Add a city or state only when you want location-specific results before checking the official study record.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 11, 2026, 10:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

5043

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Recruiting

The default view starts with recruiting studies because those are usually the most actionable.

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Live official records

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Conditions: Cardiovascular Diseases, Vascular Diseases
Interventions: Not listed
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 5 Years to 100 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2034
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: No Disease
Interventions: AdaptDx Pro; Diagnostic Test
Lead sponsor: AdaptDx, Inc.; Industry
Eligibility: 22 Years to 49 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Silverdale, Washington

Conditions: Healthy Volunteers
Interventions: E2086; Drug
Lead sponsor: Eisai Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 93 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Metabolic Disorders, Cancer, Chronic Kidney Disease, Diabetes, Normal Physiology
Interventions: Not listed
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 2 Years to 99 Years
Enrollment: 2,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2031
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Still's Disease, Adult-Onset, Systemic Inflammation, Arthritis, Autoinflammatory Syndrome
Interventions: Not listed
Lead sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); NIH
Eligibility: 1 Day to 100 Years
Enrollment: 2,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2050
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Stress Urinary Incontinence
Interventions: ProACT Adjustable Continence Therapy for Men; Device
Lead sponsor: Uromedica; Industry
Eligibility: 50 Years and older · Male only
Enrollment: 145 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2031
U.S. locations: 14
States / cities: Los Angeles, California • Santa Barbara, California • Denver, Colorado + 11 more

Conditions: EBV, Epstein-Barr Virus Infection, Infectious Mononucleosis, Mono
Interventions: EBV gp350-ferritin vaccine with ALFQ adjuvant, EBV gH/gL/gp42-ferritin nanoparticle vaccine with ALFQ adjuvant; Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 29 Years
Enrollment: 750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Cardiometabolic Health
Interventions: Animal-Based Protein Smoothie, Plant-Based Protein Smoothie, Plant-Based Protein Smoothie with Leucine; Dietary Supplement
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Alcohol Use Disorder
Interventions: Naltrexone; Drug
Lead sponsor: Milky Kohno; Other
Eligibility: 18 Years to 60 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Knee Injuries
Interventions: Physical Therapy; Other
Lead sponsor: Twin Cities Orthopedics; Other
Eligibility: 14 Years to 59 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: Edina, Minnesota

Conditions: Bronchopulmonary Dysplasia, Pulmonary Hypertension
Interventions: higher oxygen saturation target using Nellcor pulse oximetry sensors, lower oxygen saturation target using Nellcor pulse oximetry sensors; Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 1 Month to 5 Months
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Birmingham, Alabama • New Haven, Connecticut

Conditions: Healthy Participants
Interventions: S-892216-LAI, Placebo; Drug
Lead sponsor: Shionogi; Industry
Eligibility: 18 Years to 55 Years · Male only
Enrollment: 98 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Lenexa, Kansas • Salt Lake City, Utah

Healthy volunteer clinical trials in the U.S.

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Live official records

Thrombosis and Inflammation in Vessels Initiative (TIVI)

A Study to Test the Repeatability and Reproducibility in Rod Intercept Time Within the AdaptDx Pro in Healthy Subjects With Normal Vision (FlashForward)

A Study to Assess Potential Drug-Drug Interactions of E2086 in Healthy Participants

A Natural History Study of Metabolic Sizing in Health and Disease

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

ProACT Post-Approval Study

Epstein-Barr Virus (EBV) gH/gL/gp42-Ferritin Nanoparticle Vaccine With or Without gp350-Ferritin in Healthy Adults With or Without EBV Infection

How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses

Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction

Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants