Healthy Volunteer Hub

Healthy volunteer clinical trials in the U.S.

This page focuses on public ClinicalTrials.gov records that explicitly say they accept healthy volunteers. It starts with recruiting studies by default, and it does not guess the visitor's location. Add a city or state only when you want location-specific results before checking the official study record.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 2, 2026, 9:49 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

5041

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Recruiting

The default view starts with recruiting studies because those are usually the most actionable.

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Live official records

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Conditions: Eye Diseases
Interventions: Not listed
Lead sponsor: National Eye Institute (NEI); NIH
Eligibility: 2 Years to 100 Years
Enrollment: 10,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2008
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: COVID-19
Interventions: OCU500; Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 64 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 6
States / cities: Decatur, Georgia • Baltimore, Maryland • Boston, Massachusetts + 2 more

Conditions: HIV, Pre-exposure Prophylaxis, Case Management, Contingency Management
Interventions: Dyadic Case Management; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Intellectual Disability
Interventions: TSA2 Thermosensory Stimulator; Device
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 8 Years to 30 Years
Enrollment: 215 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Influenza, Human
Interventions: BPL-1357 IM, BPL-1357 IN, Placebo IM, Placebo IN; Biological · Other
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 129 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Bethesda, Maryland • Galveston, Texas

Conditions: Pulmonary Disease, Pulmonary Hypertension
Interventions: Not listed
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 270 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Healthy Volunteers
Interventions: Survey; Other
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 120 Years
Enrollment: 75,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Edentulism, Dental Implants, TNF-alpha Inhibitors
Interventions: Placement of dental implants; Procedure
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Breast Carcinoma, Healthy Subject
Interventions: Photoacoustic Imaging; Procedure
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Irritability
Interventions: Frustration task; Other
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Bethesda, Maryland • College Station, Texas

Conditions: Heart Diseases, Cardiovascular Disease
Interventions: Whole Milk-Skim Milk, Skim Milk-Whole Milk; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Normal Physiology
Interventions: 3T and 7T device; Device
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2030
U.S. locations: 1
States / cities: Bethesda, Maryland

Healthy volunteer clinical trials in the U.S.

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Live official records

Screening for Research Participants

A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults

Case Management Dyad

Characterization of Nociception Phenotype in Individuals With Intellectual Disability

BPL-1357 Against H1N1 Influenza Virus Challenge

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Survey to Determine Incarcerated Persons' Views on Surrogate Decision Making

Dental Implant Healing With TNF-Alpha Inhibitors

Photoacoustic Imaging of the Breast in Patients With Breast Cancer and Healthy Subjects

Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers

Gauging Outcomes of Total Milk Ingestion on Lipid and gControl

MRS Measurement of Glutamate and GABA Metabolism in Brain