Healthy Volunteer Hub

Healthy volunteer clinical trials in the U.S.

This page focuses on public ClinicalTrials.gov records that explicitly say they accept healthy volunteers. It starts with recruiting studies by default, and it does not guess the visitor's location. Add a city or state only when you want location-specific results before checking the official study record.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

5021

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Recruiting

The default view starts with recruiting studies because those are usually the most actionable.

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Live official records

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Conditions: Diabetes, Heart Disease, Asthma
Interventions: Not listed
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS); NIH
Eligibility: 18 Years to 120 Years
Enrollment: 25,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2010
U.S. locations: 2
States / cities: Chapel Hill, North Carolina • Research Triangle Park, North Carolina

Conditions: Syphilis Infection
Interventions: Rapid Syphilis Test; Diagnostic Test
Lead sponsor: Queen's Medical Center; Other
Eligibility: 14 Years and older · Female only
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Healthy Volunteers, HIV
Interventions: Not listed
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 3,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 1984
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Colorectal Cancer Screening, Hepatitis C Virus
Interventions: MATCHES; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 45 Years to 75 Years
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Multiple Sclerosis
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 18 Years to 120 Years
Enrollment: 3,750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 1992
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Healthy, Iron Overload, Liver Fat
Interventions: Non-contrast MRI with novel MRI software; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 7 Years and older
Enrollment: 204 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Breast Cancer, Cancer of the Breast
Interventions: Prognosia Breast, Mammogram, MRI; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 25 Years to 55 Years · Female only
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Diabetes
Interventions: Not listed
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 18 Years to 120 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Psychological Stress, Cardiovascular Diseases, Cerebrovascular Disorders
Interventions: Paced Auditory Serial Addition Task; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 40 Years to 59 Years
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: PASC Post Acute Sequelae of COVID-19
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 18 Years to 110 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: HSCT, Respiratory, Gas Exchange Impairment
Interventions: Hyperpolarized 129 Xenon; Drug
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 3 Years and older
Enrollment: 550 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Healthy Volunteer, Older Adults (65-85 Years)
Interventions: Psilocybin (Usona Institute); Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 65 Years to 85 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 6
States / cities: San Francisco, California • Aurora, Colorado • Atlanta, Georgia + 3 more

Healthy volunteer clinical trials in the U.S.

Filter healthy volunteer studies

Live official records

Personalized Environment and Genes Study

Feasibility and Acceptability of Point of Care Rapid Syphilis Testing Among Patients Seeking Family Planning Services in Hawai'i

Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies

Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Fully Automated High-Throughput Quantitative MRI of the Liver

Precision Supplemental Imaging in Women With Dense Breasts

Taste Bud-Derived Stem Cells in Humans

Cerebrovascular Health and Resilience in Midlife

Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection

Assessing Pulmonary Changes in HSCT

Safety and Tolerability Trial of Psilocybin in Healthy Older Adults