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ClinicalTrials.gov public records Last synced Oct 21, 2026, 5:36 AM EDT

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Showing 97–120 of 229 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: ACL Clear all
Completed No phase listed Observational Accepts healthy volunteers

Knee Alignment Contributions to Anterior Cruciate Ligament (ACL) Injury

NCT00855023
View directory record Official record
Conditions
Knee Injuries
Interventions
Not listed
Lead sponsor
The Orthopaedic Center, Maryland
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Oct 21, 2026, 5:36 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

BFRT in Adolescents After ACL Reconstruction

NCT04390035
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Oct 21, 2026, 5:36 AM EDT
Completed No phase listed Observational

Sport Cord Test Following ACL Reconstruction

NCT01937403
View directory record Official record
Conditions
Injury of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
The Hawkins Foundation
Other
Eligibility
10 Years to 50 Years
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional

Improving ACL Reconstruction Outcomes: CBPT

NCT03243162
View directory record Official record
Conditions
ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL Sprain, ACL Tear
Interventions
CBPT-ACLR, Education
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Garfield Heights, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Oct 21, 2026, 5:36 AM EDT
Not listed Phase 4 Interventional

IPACK on Early Pain Scores After ACL Reconstruction

NCT05985629
View directory record Official record
Conditions
Pain, Postoperative, Anterior Cruciate Ligament Injuries, Analgesics, Opioid
Interventions
IPACK, PLACEBO
Drug
Lead sponsor
Loyola University
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 21, 2026, 5:36 AM EDT
Withdrawn Phase 4 Interventional

Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction

NCT07115056
View directory record Official record
Conditions
ACL Injury, ACL Tears, ACL Surgery
Interventions
Tranexamic Acid (TXA), Placebo
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 22 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
6
States / cities
Evanston, Illinois • Chesterfield, Missouri • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

NCT01034527
View directory record Official record
Conditions
ACL Injury
Interventions
Neuromuscular Training
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 19 Years · Female only
Enrollment
593 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 4, 2020 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional Results available

Anterior Cruciate Ligament Reconstruction and Plyometric Exercise

NCT01851655
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Plyometric Exercise
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 30 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 18, 2014 · Synced Oct 21, 2026, 5:36 AM EDT
Withdrawn Not applicable Interventional

BFR Therapy After ACL Reconstruction

NCT03794570
View directory record Official record
Conditions
ACL Injury, Quadriceps Muscle Atrophy
Interventions
Blood flow restriction therapy - with Delfi Personalized Tourniquet System, Sham blood flow restriction therapy - with Delfi Personalized Tourniquet System
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
14 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 21, 2026, 5:36 AM EDT
Not yet recruiting Not applicable Interventional

Cryoneurolysis in Anterior Cruciate Ligament Reconstruction (ACLR)

NCT07731178
View directory record Official record
Conditions
ACL Reconstruction (ACLR) With a Bone-patellar Tendon-bone (BPTB) Autograft
Interventions
Pacira Iovera Cryoneurolysis device, Placebo/Sham device
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 45 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional Results available

The Effect of Various Strength Training Protocols in ACL Reconstructed Participants

NCT03364647
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear, Physical Therapy
Interventions
Arm A - blood flow restriction training, Arm B - standard of care
Other
Lead sponsor
Brian W. Noehren
Other
Eligibility
15 Years to 40 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Phase 3 Interventional

Double-Blind, Randomized Study Of The Analgesic Efficacy And Safety Of Valdecoxib 20 Mg Daily And Valdecoxib 20 Mg Twice Daily Compared To Placebo For Management Of Acute Postsurgical Pain In Anterior Cruciate Ligament (ACL) Reconstruction

NCT00650039
View directory record Official record
Conditions
Pain
Interventions
placebo, valdecoxib
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
68
States / cities
Birmingham, Alabama • Northport, Alabama • Glendale, Arizona + 46 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2008 · Synced Oct 21, 2026, 5:36 AM EDT
Not yet recruiting Not applicable Interventional

Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

NCT07142369
View directory record Official record
Conditions
Posttraumatic Osteoarthritis, Anterior Cruciate Ligament (ACL) Rupture
Interventions
Synovial Fluid withdrawal at the preoperative clinic visit, Platelet-Rich Plasma (PRP) preparation and injection, Synovial fluid withdrawal at the time of surgery, 3mL synovial fluid withdrawn at the preoperative visit
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 21, 2026, 5:36 AM EDT
Active, not recruiting Not applicable Interventional

The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration

NCT03348995
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Bridge-Enhanced ACL Restoration (BEAR)
Device
Lead sponsor
Miach Orthopaedics
Industry
Eligibility
12 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2034
U.S. locations
11
States / cities
San Diego, California • Tampa, Florida • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 21, 2026, 5:36 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Decreasing Knee Injury Risk Factors With Neuromuscular Training

NCT01433718
View directory record Official record
Conditions
ACL, Anterior Cruciate Ligament Injury
Interventions
Neuromuscular and Resistance Training
Procedure
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 20 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional

Bioactive Knee Sleeves After ACL Reconstruction

NCT07707128
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Interventions
Bioactive Knee Sleeve
Device
Lead sponsor
Western Kentucky Heart and Lung Research Foundation and Educational Trust
Other
Eligibility
16 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Design and Evaluation of an Active Intervention for the Prevention of Non-contact ACL Injury

NCT01021111
View directory record Official record
Conditions
Athletic Injuries, Sprains and Strains, Wounds and Injuries, Knee Injuries
Interventions
Activity Training with Feedback
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional

Optimizing Plyometric Training for Functional Recovery Post-ACL Reconstruction

NCT02148172
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Knee Injury
Interventions
Standard Plyometric Training, Plyometric Training with BWS
Procedure
Lead sponsor
University of Montana
Other
Eligibility
12 Years to 35 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Oct 21, 2026, 5:36 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Risk Factors for Anterior Cruciate Ligament (ACL) Injury

NCT00124319
View directory record Official record
Conditions
Knee Injuries, Athletic Injuries
Interventions
Not listed
Lead sponsor
Steve Marshall
Other
Eligibility
18 Years and older
Enrollment
4,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
3
States / cities
Colorado Springs, Colorado • Annapolis, Maryland • West Point, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2011 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Phase 4 Interventional

Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction

NCT00022854
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Single-injection femoral nerve block, Femoral nerve block 60-hour continuous injection, Saline (control) injection into femoral nerve envelope
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 65 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2013 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional

External Focus of Attention Posttraumatic Osteoarthritis

NCT04922268
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Osteo Arthritis Knee
Interventions
Internal focus of attention feedback, External focus of attention feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 35 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 24, 2024 · Synced Oct 21, 2026, 5:36 AM EDT
Completed Not applicable Interventional

Operant Conditioning After ACL Reconstruction

NCT05519345
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Operant Conditioning, Control
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 21, 2026, 5:36 AM EDT
Recruiting Not applicable Interventional

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

NCT06942754
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
post-surgical functional bracing
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
14 Years to 39 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 21, 2026, 5:36 AM EDT