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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: ACL Injuries Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Do Oral Contraceptives Protect Against ACL Injuries in Female Athletes

NCT04899778
View directory record Official record
Conditions
Ligament Injury
Interventions
Oral Contraceptive Pill, norethindrn a-e estradiol-iron
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Jul 21, 2026, 10:17 PM EDT
Enrolling by invitation Phase 3 Interventional

ACL-R Opioid Sparing Study

NCT06561035
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Opiate Sparing, Opiate Based
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 85 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Jul 21, 2026, 10:17 PM EDT
Active, not recruiting Not applicable Interventional

STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon

NCT03935750
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
Interventions
Anterior cruciate ligament reconstruction (ACLR), Lateral extra-articular tenodesis (LET)
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 25 Years
Enrollment
1,272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
14
States / cities
Redwood City, California • San Francisco, California • Orlando, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neuroplastic Mechanisms Underlying Augmented Neuromuscular Training

NCT04069520
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
aNMT Biofeedback, Sham Biofeedback
Other
Lead sponsor
Emory University
Other
Eligibility
12 Years to 19 Years · Female only
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Flowery Branch, Georgia • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Jul 21, 2026, 10:17 PM EDT
Not yet recruiting Phase 2 Interventional

Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population

NCT06559137
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children, Analgesia, Pain, Postoperative
Interventions
Ropivacaine 0.2% Injectable Solution
Drug
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
13 Years to 21 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jul 21, 2026, 10:17 PM EDT
Completed No phase listed Observational

Prospective Registry of Anterior Cruciate Ligament Reconstructions

NCT04135950
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Meniscal Tear, Cartilage Injury, Bone Bruising
Interventions
Not listed
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
Not listed
Enrollment
1,646 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2025
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 21, 2026, 10:17 PM EDT
Recruiting No phase listed Observational

BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures

NCT06948591
View directory record Official record
Conditions
ACL Tears
Interventions
Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
Device · Procedure
Lead sponsor
CONMED Corporation
Industry
Eligibility
14 Years to 70 Years
Enrollment
500 participants
Timeline
2025 – 2030
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Completed No phase listed Observational

Anterior Cruciate Ligament (ACL) Reconstruction- Bioabsorbable Screw

NCT01069588
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years to 35 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Jul 21, 2026, 10:17 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Training of Falling Techniques on Landing Mechanics

NCT04768088
View directory record Official record
Conditions
Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
Interventions
Falling Training
Other
Lead sponsor
University of Wyoming
Other
Eligibility
14 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Laramie, Wyoming
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jul 21, 2026, 10:17 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Biologic Therapy to Prevent Osteoarthritis After ACL Injury

NCT03968913
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Anakinra injection, sterile saline injection
Drug · Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 35 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mechanical Perturbation Training for ACL Injury Prevention

NCT03080402
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, ACL
Interventions
Mechanical Perturbation Training
Device
Lead sponsor
University of Delaware
Other
Eligibility
15 Years to 30 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 14, 2017 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Phase 3 Interventional Results available

Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound

NCT04993339
View directory record Official record
Conditions
ACL Injury
Interventions
OOC
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Jul 21, 2026, 10:17 PM EDT
Recruiting Not applicable Interventional

Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

NCT05949177
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Graded Exposure and Mindfulness Meditation, Waitlist Control
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
14 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Jul 21, 2026, 10:17 PM EDT
Withdrawn Not applicable Interventional

Internal Bracing Following ACL Reconstruction

NCT06289153
View directory record Official record
Conditions
ACL Injury
Interventions
Arthrex Internal Brace, ACL Reconstruction
Device · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Phase 2 Interventional

Single- vs. Double-Bundle ACL Reconstruction

NCT01319409
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Anatomic Double-Bundle ACL Reconstruction, Anatomic Single-Bundle ACL Reconstruction
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 50 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2016 · Synced Jul 21, 2026, 10:17 PM EDT
Recruiting Phase 3 Interventional

PRP in ACLR to Prevent PTOA

NCT05412381
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, PRP
Interventions
platelet rich plasma (PRP) injection, placebo saline injection
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
14 Years to 50 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Not applicable Interventional

Optimizing Gait Biomechanics for Posttraumatic Osteoarthritis Prevention

NCT05007366
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Knee Injuries, Cartilage, Articular, Gait
Interventions
Real-time gait biofeedback, Sham real-time gait biofeedback
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Jul 21, 2026, 10:17 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Baseline ACL Injury Risk Screening and Normative Data

NCT06635668
View directory record Official record
Conditions
ACL Injury, Anterior Cruciate Ligament Injuries, Musculoskeletal Injury
Interventions
Not listed
Lead sponsor
Sanford Health
Other
Eligibility
10 Years to 65 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2033
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Decreasing Knee Injury Risk Factors With Neuromuscular Training

NCT01433718
View directory record Official record
Conditions
ACL, Anterior Cruciate Ligament Injury
Interventions
Neuromuscular and Resistance Training
Procedure
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 20 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Not applicable Interventional Results available

Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion

NCT04906499
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Exercise, Cartilage, Articular, Knee Injuries, Osteoarthritis, Osteoarthritis, Knee, Arthritis, Joint Diseases
Interventions
Physical Activity Promotion
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2024 · Synced Jul 21, 2026, 10:17 PM EDT
Active, not recruiting Not applicable Interventional

The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration

NCT03348995
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Bridge-Enhanced ACL Restoration (BEAR)
Device
Lead sponsor
Miach Orthopaedics
Industry
Eligibility
12 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2034
U.S. locations
11
States / cities
San Diego, California • Tampa, Florida • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Not yet recruiting No phase listed Observational

MRI Evaluation of Graft Maturation Following ACL Reconstruction

NCT07046000
View directory record Official record
Conditions
ACL Tears
Interventions
MRI
Diagnostic Test
Lead sponsor
Skye Biologics Holdings, LLC
Industry
Eligibility
14 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Initial Graft Tension and ACL Surgery

NCT00434837
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Initial graft tension during ACL reconstruction surgery
Procedure
Lead sponsor
Rhode Island Hospital
Other
Eligibility
15 Years to 50 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2024
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jul 21, 2026, 10:17 PM EDT
Completed Not applicable Interventional

Tibial Tunnel Placement for ACL Reconstruction

NCT02374710
View directory record Official record
Conditions
Complete Tear, Knee, Anterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
Interventions
ACL Reconstruction: Anterior Tunnel, ACL Reconstruction: Posterior Tunnel
Procedure
Lead sponsor
University of Virginia
Other
Eligibility
16 Years to 50 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Jul 21, 2026, 10:17 PM EDT