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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:50 AM EDT

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Showing 73–96 of 156 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: ACL Reconstruction Clear all
Completed No phase listed Observational Accepts healthy volunteers

Gabapentin Premedication for ACL Reconstruction: RCT

NCT03417479
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction
Interventions
Gabapentin
Other
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2021 · Synced Oct 20, 2026, 4:50 AM EDT
Completed No phase listed Observational

Sport Cord Test Following ACL Reconstruction

NCT01937403
View directory record Official record
Conditions
Injury of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
The Hawkins Foundation
Other
Eligibility
10 Years to 50 Years
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 20, 2026, 4:50 AM EDT
Completed No phase listed Observational

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up

NCT00478894
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
14 Years to 55 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Terminated Phase 3 Interventional Results available

IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction

NCT03983941
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
Ropivacaine injection
Drug
Lead sponsor
Sujana Dontukurthy
Other
Eligibility
Up to 21 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 20, 2026, 4:50 AM EDT
Withdrawn Not applicable Interventional

Internal Bracing Following ACL Reconstruction

NCT06289153
View directory record Official record
Conditions
ACL Injury
Interventions
Arthrex Internal Brace, ACL Reconstruction
Device · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Phase 4 Interventional Results available

Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following ACL Reconstruction With Bone Patellar Tendon Bone Autograft:

NCT05286307
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
IPACK block
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 20, 2026, 4:50 AM EDT
Not yet recruiting Phase 2 Interventional

Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population

NCT06559137
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children, Analgesia, Pain, Postoperative
Interventions
Ropivacaine 0.2% Injectable Solution
Drug
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
13 Years to 21 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Phase 3 Interventional

Safety of OMS103HP in Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction

NCT00245271
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
OMS103HP, Vehicle
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
17 Years to 65 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
10
States / cities
Los Angeles, California • Redwood City, California • Denver, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2011 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bone Tunnel Widening Following ACL Reconstruction

NCT00198042
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Knee Injuries
Interventions
Surgical reconstruction of the ACL
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Oct 20, 2026, 4:50 AM EDT
Withdrawn Not applicable Interventional

BFR Therapy After ACL Reconstruction

NCT03794570
View directory record Official record
Conditions
ACL Injury, Quadriceps Muscle Atrophy
Interventions
Blood flow restriction therapy - with Delfi Personalized Tourniquet System, Sham blood flow restriction therapy - with Delfi Personalized Tourniquet System
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
14 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Not applicable Interventional

Comparison of Doubled Quadrupled Versus Quadrupled Allograft Tissue Constructs for Anterior Cruciate Ligament (ACL) Reconstruction

NCT01148784
View directory record Official record
Conditions
Anterior Cruciate Ligament, Injury
Interventions
ACL reconstruction
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 70 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Oct 20, 2026, 4:50 AM EDT
Active, not recruiting Not applicable Interventional

A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

NCT03776162
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
Procedure · Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boulder, Colorado • Bloomington, Minnesota • Cleveland, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Biocleanse Allografts For ACL Reconstruction

NCT00187876
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL reconstruction control, ACL Biocleanse, surgical
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2014 · Synced Oct 20, 2026, 4:50 AM EDT
Enrolling by invitation Not applicable Interventional

Use of Simplified Pain Questionnaire Among People Receiving Anterior Cruciate Ligament (ACL) Knee Surgery?

NCT07065266
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction, Anterior Cruciate Ligament/Surgery
Interventions
Binary pain questionnaire, Numerical Pain Rating Scale (NPRS)
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Enrolling by invitation Not applicable Interventional

Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients

NCT07171346
View directory record Official record
Conditions
ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy, Muscle Atrophy or Weakness
Interventions
Zynex NexWave Electrotherapy Device
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
15 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Enrolling by invitation Not applicable Interventional

A Study Of Focused Shockwave For Anterior Knee Pain Following Anterior Cruciate Ligament Reconstruction

NCT07580157
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Focused Shockwave, Sham Focused Shockwave
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Phase 4 Interventional

Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction

NCT00022854
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Single-injection femoral nerve block, Femoral nerve block 60-hour continuous injection, Saline (control) injection into femoral nerve envelope
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 65 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2013 · Synced Oct 20, 2026, 4:50 AM EDT
Not yet recruiting Phase 3 Interventional

Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction

NCT07880743
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Dave Bernholt
Other
Eligibility
14 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
6
States / cities
Skokie, Illinois • St Louis, Missouri • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength

NCT03033589
View directory record Official record
Conditions
Pain
Interventions
Marcaine 0.25 % Injectable Solution
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
16 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 20, 2026, 4:50 AM EDT
Not listed Phase 1Phase 2 Interventional

Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction

NCT04205656
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Leukocyte-Poor Platelet Rich Plasma (LP-PRP), Bone Marrow Concentrate (BMC), Control group (Placebo)
Biological · Other
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
16 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Oct 20, 2026, 4:50 AM EDT
Active, not recruiting Not applicable Interventional

Anterior Cruciate Ligament Reconstruction Hybrid Remnant Repair

NCT05494073
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
ACL Reconstruction with Hybrid Remnant Repair, ACL Reconstruction without Hybrid Remnant Repair
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
13 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 8, 2025 · Synced Oct 20, 2026, 4:50 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction

NCT05161221
View directory record Official record
Conditions
Pain, Postoperative, ACL
Interventions
OxyCODONE 5 mg Oral Tablet, Naproxen 500 Mg, Tylenol Pill, Liposomal bupivacaine, Femoral Nerve Catheter
Drug · Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2021 · Synced Oct 20, 2026, 4:50 AM EDT
Terminated Not applicable Interventional

Effects of Femoral vs Saphenous Nerve Blocks on Function After ACL Repair

NCT01919658
View directory record Official record
Conditions
Anterior Cruciate Ligament
Interventions
nerve block
Procedure
Lead sponsor
Robert A. Gallo
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2019 · Synced Oct 20, 2026, 4:50 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Exparel vs. ACB With Bupivacaine for ACL Reconstruction

NCT06274008
View directory record Official record
Conditions
ACL Tear, Opioid Misuse, Pain, Anxiety
Interventions
Exparel
Drug
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
7 Years to 17 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2024 · Synced Oct 20, 2026, 4:50 AM EDT