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ClinicalTrials.gov public records Last synced Sep 9, 2026, 1:55 AM EDT

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Showing 1–24 of 474 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: ARTHROPLASTY, REPLACEMENT Clear all
Completed Not applicable Interventional Results available

Trident® Tritanium™ Acetabular Shell Revision Study

NCT00535626
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
Trident® Tritanium™ Acetabular Shell
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
21 Years to 85 Years
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2016
U.S. locations
15
States / cities
Orange, California • Jacksonville, Florida • Miami, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2017 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional

Preventing Smoking Relapse After Total Joint Replacement Surgery

NCT03673228
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Comprehensive Relapse Prevention Intervention, Standard Treatment Counseling, Nicotine Replacement Therapy (NRT)
Behavioral · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 100 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 11, 2021 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional

Reverse Shoulder Replacement: Formal vs. Home Physiotherapy

NCT03430167
View directory record Official record
Conditions
Shoulder Arthropathy Associated With Other Conditions
Interventions
home therapy, formal therapy
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
61 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Phase 4 Interventional Results available

Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions

NCT00739583
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
CHG 2% w/v and IPA 70% v/v, Iodophor 0.7% and IPA 74% w/w
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational

Novel Strategies for Personalized Clinical Decisions in Knee Arthroplasty

NCT05900453
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Clinical decision support (CDS) tool
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years and older
Enrollment
675 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)

NCT02197273
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
Interventions
Liposomal bupivacaine, Standard of care analgesia
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2016 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional

The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty

NCT07219329
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Weighted Blanket
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chronic Knee Pain Study

NCT00776932
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
852 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational

A Clinical Investigation of the Taperloc® Microplasty™ Hip System

NCT00699309
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis
Interventions
Not listed
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
4
States / cities
Beaufort, South Carolina • Greenville, South Carolina • Plano, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational

Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

NCT01398800
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Not listed
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
Not listed
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 23, 2019 · Synced Sep 9, 2026, 1:55 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Metal Ion Concentrations After Total Knee Arthroplasty

NCT06447922
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Total Knee Replacement, Blood Metal Ion Concentration
Interventions
Metal ion level testing
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 9, 2026, 1:55 AM EDT
Terminated Not applicable Interventional

Signature Personalised Patient Care System With the Vanguard Knee System Study

NCT01092312
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Vanguard Knee System with Signature Knee Guide, Vanguard Knee System with conventional Instruments
Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2017 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

36 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement

NCT00953719
View directory record Official record
Conditions
Non-inflammatory Degenerative Joint Disease
Interventions
36 mm ceramic head on a ceramic acetabular liner, 28 mm ceramic head on a polyethylene acetabular liner
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
20 Years to 75 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2013
U.S. locations
5
States / cities
Sacramento, California • Denver, Colorado • Winston-Salem, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational

Columbia Shoulder Study (CSS)

NCT01488006
View directory record Official record
Conditions
Osteoarthritis of Glenohumeral Joint
Interventions
Bigliani/Flatow Shoulder System
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational

ASR-XL Metal-on-Metal 522 Post-Market Surveillance Study

NCT01884532
View directory record Official record
Conditions
Adverse Local Tissue Reaction, Total Hip Arthroplasty
Interventions
ASR-XL Metal-on-Metal
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
Not listed
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
7
States / cities
Fort Collins, Colorado • Glenview, Illinois • Rockford, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational Results available

Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty

NCT02276040
View directory record Official record
Conditions
Knee Pain Arthritis
Interventions
periarticular bupivicaine and liposomal bupivicaine
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Sep 9, 2026, 1:55 AM EDT
Suspended Phase 2Phase 3 Interventional

Safety of F14 Following Total Knee Replacement

NCT04860635
View directory record Official record
Conditions
Analgesia
Interventions
F14 (sustained release celecoxib)
Drug
Lead sponsor
Arthritis Innovation Corporation
Industry
Eligibility
45 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
2
States / cities
Denver, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 9, 2026, 1:55 AM EDT
Completed No phase listed Observational Results available

Comparing Ankle Fusion to Ankle Replacement

NCT01620541
View directory record Official record
Conditions
End-stage Ankle Arthritis (ESAA), Osteoarthritis (OA)
Interventions
Ankle Arthrodesis, Ankle Arthroplasty
Procedure
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
21 Years to 89 Years
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
6
States / cities
Fort Collins, Colorado • Grand Rapids, Michigan • Edina, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reparel Knee Sleeve vs. TED Hose for Post-op Swelling, Pain and Range of Motion After Total Knee Replacement

NCT04751942
View directory record Official record
Conditions
Osteoarthritis Knees Both
Interventions
Non-compressive Bioactive Garment, thrombo-embolic deterrent
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Beachwood, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Sep 9, 2026, 1:55 AM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine in Total Knee Arthroplasty

NCT02426164
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions
Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
Drug
Lead sponsor
Miller Orthopedic Specialists
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Council Bluffs, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 21, 2016 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery

NCT05252858
View directory record Official record
Conditions
Opioid Use, Pain, Post Operative
Interventions
nCAP Signal Relief Patch, Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The PATH Study to Promote Physical Activity After Knee Replacement

NCT03768206
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Standard Physical Therapy, Physical therapist discuss aerobic physical activity, Physical activity session
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
40 Years to 79 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Sep 9, 2026, 1:55 AM EDT
Recruiting Not applicable Interventional

Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection

NCT06293352
View directory record Official record
Conditions
Prosthetic-joint Infection, Knee Infection, Arthroplasty Complications, Joint Infection, Arthroplasty, Replacement, Knee
Interventions
All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 9, 2026, 1:55 AM EDT
Completed Phase 4 Interventional Results available

Ultrasound-guided Adductor Canal Block for Total Knee Replacement

NCT02100579
View directory record Official record
Conditions
Complications; Arthroplasty, Knee Injuries
Interventions
Bupivacaine, Preservative free normal saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 9, 2026, 1:55 AM EDT