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ClinicalTrials.gov public records Last synced Oct 3, 2026, 6:45 PM EDT

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Showing 25–48 of 460 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Abuse, Drug Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Disulfiram Interactions With HIV Medications: Clinical Implications

NCT00878306
View directory record Official record
Conditions
HIV Infections, Drug Abuse
Interventions
Disulfiram, Disulfiram + Efavirenz, Disulfiram + Atazanavir, Disulfiram + Ritonavir
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 6, 2014 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adolescent Family-Based Alcohol Prevention

NCT00858065
View directory record Official record
Conditions
Alcohol Abuse, Drug Abuse
Interventions
Strengthening Families Program (SFP), Family Matters
Behavioral
Lead sponsor
Pacific Institute for Research and Evaluation
Other
Eligibility
11 Years to 12 Years
Enrollment
1,228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
2
States / cities
Berkeley, California • Oakland, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Multimedia Toolkits to Implement 12-Step Recovery Concepts in Group Counseling

NCT02333357
View directory record Official record
Conditions
Alcohol Abuse, Drug Abuse
Interventions
Multimedia 12-Step Toolkit, Treatment as Usual
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
3,483 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
11
States / cities
Camden, New Jersey • Brooklyn, New York • Eagleville, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 2 Interventional

Brief Intervention for Drug Misuse in the Emergency Department

NCT01124591
View directory record Official record
Conditions
Substance Abuse Detection, HIV, Hepatitis B, Hepatitis C, Brief Intervention, HIV Infections
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
1,030 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 3, 2026, 6:45 PM EDT
Completed No phase listed Observational

Quantification of Cannabinoids and Comparison to Post-Surgical Pain Medication Requirements and Surgical Outcomes

NCT04988490
View directory record Official record
Conditions
Post-Surgical Pain, Post-Surgical Complication, Cancer, Cannabis Use
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Oct 3, 2026, 6:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Screening Evaluation for Studies of the National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT00001673
View directory record Official record
Conditions
Alcoholic Intoxication, Alcoholism, Healthy
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
2,220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Study of the Abuse Potential of Lasmiditan in Participants Who Are Recreational Drug Users

NCT03286218
View directory record Official record
Conditions
Recreational Drug Use, Prescription Drug Abuse (Not Dependent)
Interventions
Lasmiditan, Alprazolam, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 55 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 10, 2020 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Screening, Brief Intervention, and Referral to Treatment for Drug Use

NCT01683227
View directory record Official record
Conditions
Drug Abuse
Interventions
Screening/motivational drug intervention, Motivational placebo intervention
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 100 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Oct 3, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional

Neuroimaging of Adolescent Cannabis Use Treatment

NCT07340554
View directory record Official record
Conditions
Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

An Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics (PK) of Sativex® in Healthy Subjects With Cannabis Experience.

NCT02325011
View directory record Official record
Conditions
Healthy Subjects
Interventions
Sativex® (Treatment A), Sativex® and fluconazole concomitantly (Treatment B)
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional

Integrating Substance Abuse Assessment & Intervention in Primary Care Settings

NCT01751672
View directory record Official record
Conditions
Drug Use, Alcohol Use
Interventions
SBIRT+
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Family Training Program for Parents of Substance Using Adolescents

NCT01344382
View directory record Official record
Conditions
Substance-Related Disorders, Drug Addiction, Substance Abuse
Interventions
Community Reinforcement and Family Training, Al-Anon Facilitation
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
12 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 3, 2026, 6:45 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis

NCT04033562
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Use, Opioid Dependence, Opioid Abuse, Medication Assisted Treatment, Infusion Catheter, Wound, Lidopatch, Ambu ACTion, Pregnancy Related, Cesarean Section
Interventions
Lidocaine patch, Ambu ACTion pump, 0.125% bupivacaine at 8cc/hr
Drug · Device
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Oct 3, 2026, 6:45 PM EDT
Completed No phase listed Observational Results available

Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study

NCT00653263
View directory record Official record
Conditions
Methamphetamine Dependence, Methamphetamine Withdrawal
Interventions
Not listed
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Drug Abuse Among Sexual Minority Youth

NCT03954535
View directory record Official record
Conditions
Substance Abuse
Interventions
Free2b, Attention-Placebo
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years to 17 Years
Enrollment
1,216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Oct 3, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Wakaya: Rising Up for Choctaw Youth Health

NCT05818384
View directory record Official record
Conditions
Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
Interventions
Wakaya: Rising Up for Choctaw Youth Curriculum
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 19 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Durant, Oklahoma • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 3, 2026, 6:45 PM EDT
Terminated Phase 4 Interventional Results available

Buprenorphine as a Treatment in Opiate Dependent Pain Patients

NCT00552578
View directory record Official record
Conditions
Opiate Addiction, Refractory Pain
Interventions
buprenorphine/naloxone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2011 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Abuse Potential Study of PF-00345439

NCT01986283
View directory record Official record
Conditions
Opioid Users
Interventions
Capsule, PF-00345439, oxycodone
Drug
Lead sponsor
Pain Therapeutics
Industry
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Early Intervention for Minors in Possession of Alcohol/Drugs: A Feasibility Study

NCT01616212
View directory record Official record
Conditions
Substance Use Disorder, Delinquency
Interventions
Motivational Enhancement Therapy /Adol and PW for parents, Motivational Enhancement Therapy for adolescents, Drug Education for adolescents, Parenting Wisely for parents, Drug Education for adolescents
Other
Lead sponsor
Oregon Research Institute
Other
Eligibility
13 Years to 17 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 10, 2014 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brief Intervention for Rural Women at High Risk for HIV/HCV

NCT01840722
View directory record Official record
Conditions
Acquired Immune Deficiency Syndrome Virus, Hepatitis C, Drug Abuse
Interventions
MI-based HIV Risk Reduction
Other
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Hazard, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 4 Interventional Results available

N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use

NCT04627922
View directory record Official record
Conditions
Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
Interventions
N-Acetyl cysteine, Placebo comparator, Cognitive behavioral therapy (CBT)
Drug · Other · Behavioral
Lead sponsor
Ellen Herbst
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family-based and Adolescent Residential Drug Treatment

NCT01737632
View directory record Official record
Conditions
Substance Use, Delinquency
Interventions
Multidimensional Family Therapy (MDFT), Adolescent Residential Treatment
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 17 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2010
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 29, 2012 · Synced Oct 3, 2026, 6:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience

NCT04570436
View directory record Official record
Conditions
Abuse Potential
Interventions
gabapentin 600 mg, gabapentin 1200 mg, gabapentin 1800 mg, diazepam 20 mg, placebo
Drug · Other
Lead sponsor
Viatris Specialty LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Oct 3, 2026, 6:45 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Brain Glutamate Receptors and Cocaine Dependence

NCT00951314
View directory record Official record
Conditions
Drug Abuse, Cocaine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 3, 2026, 6:45 PM EDT