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Showing 1–24 of 1,401 matching trials from the live ClinicalTrials.gov search.
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Terminated No phase listed Observational

Methylphenidate Studies for Drug Abuse Vulnerability Molecular Genentics

NCT00247689
View directory record Official record
Conditions
Substance Abuse
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional Results available

Feasibility of Providing Computerized CBT in the Black Church

NCT03579290
View directory record Official record
Conditions
Substance Abuse
Interventions
CBT4CBT program
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 1Phase 2 Interventional

Acute Intervention to Reduce Distress Following Sexual Assault

NCT01622855
View directory record Official record
Conditions
Drug Use, Drug Abuse, Posttraumatic Stress Disorder
Interventions
PPRS
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
14 Years to 90 Years · Female only
Enrollment
442 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Sep 11, 2026, 3:36 PM EDT
Recruiting Not applicable Interventional

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

NCT04927143
View directory record Official record
Conditions
Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Interventions
App-Based Contingency Management, Sham Control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oconomowoc, Wisconsin • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 11, 2026, 3:36 PM EDT
Completed No phase listed Observational

Specialized Substance Abuse Supervision (SSAS) Versus Non-SSAS Recidivism Rates Among Nebraska Felony Drug Offenders

NCT00690352
View directory record Official record
Conditions
Substance-related Disorders, Alcohol-related Disorders
Interventions
Specialized Substance Abuse Supervision (SSAS)
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
17 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 24, 2023 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional

Young Women's CoOp Study

NCT01224184
View directory record Official record
Conditions
HIV, Sexual Risk, Sexually Transmitted Diseases, Substance Abuse, Violence, Victimization
Interventions
Young Women's CoOp, Staying Healthy and Eating Well
Behavioral
Lead sponsor
RTI International
Other
Eligibility
16 Years to 19 Years · Female only
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Durham, North Carolina • Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 11, 2026, 3:36 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study

NCT06208202
View directory record Official record
Conditions
Abuse Tobacco, Exposure
Interventions
Behavioral Intervention, Biospecimen Collection, Survey Administration
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 29 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 11, 2026, 3:36 PM EDT
Withdrawn Phase 4 Interventional

An Evaluation of Divalproex vs. Olanzapine for Alcohol Abuse Relapse Prevention in Patients With Bipolar Disorder

NCT00221481
View directory record Official record
Conditions
Bipolar Disorder
Interventions
divalproex or olanzapine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2006
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 31, 2015 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 2 Interventional Results available

A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease

NCT03582137
View directory record Official record
Conditions
Parkinson Disease
Interventions
Cannabidiol, Placebo
Drug · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years to 85 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Sep 11, 2026, 3:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

NCT01036581
View directory record Official record
Conditions
Drug Abuse, Nicotine Dependence
Interventions
MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional Results available

Progesterone for the Treatment of Cocaine Dependence - 1

NCT00218257
View directory record Official record
Conditions
Cocaine Abuse, Cocaine-Related Disorders
Interventions
Progesterone, Placebo
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 46 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Nabilone for Cannabis Dependence: A Pilot Study

NCT01347762
View directory record Official record
Conditions
Cannabis Dependence, Marijuana Dependence
Interventions
Nabilone, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 1 Interventional

Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADHD in Routine Care

NCT01539941
View directory record Official record
Conditions
Adolescent Substance Abuse, Attention Deficit Hyperactivity Disorder
Interventions
Medication integration protocol
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
13 Years to 17 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2015 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional

Onsite Versus Referral Models of Primary Care for Substance Abusing Patients

NCT00057096
View directory record Official record
Conditions
Substance Abuse, Primary Medical Care
Interventions
On-site vs. referral methods of care
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2004
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 11, 2026, 3:36 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

Haloperidol For Outpatient Symptom Management in Patients Diagnosed With Cannabinoid Hyperemesis Syndrome in the Emergrency Department

NCT07726069
View directory record Official record
Conditions
Cannabinoid Hyperemesis Syndrome
Interventions
Haloperidol
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Parenting Mindfully Study

NCT02038231
View directory record Official record
Conditions
Substance Abuse, Risk Behaviors
Interventions
Parenting Mindfully Program, Parent Education Program
Behavioral · Other
Lead sponsor
George Mason University
Other
Eligibility
12 Years to 16 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional

Treatment of Post-Traumatic Stress Disorder (PTSD) in Sexually Abused Children

NCT00000383
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Trauma-Focused CBT, Child-Centered Therapy
Behavioral
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
8 Years to 14 Years
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
3
States / cities
Stratford, New Jersey • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2015 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional Results available

The Long-Term Treatment of Drug Addiction and Unemployment

NCT02487745
View directory record Official record
Conditions
Substance Abuse, Intravenous
Interventions
Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2022 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 2 Interventional Results available

Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence

NCT02210195
View directory record Official record
Conditions
Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder, Alcohol Use Disorder
Interventions
aprepitant, Placebo, Manual-guided behavioral counseling
Drug · Behavioral
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2017 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 3 Interventional

Motivational Enhancement to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse - 1

NCT00032981
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Behavior Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 99 Years
Enrollment
561 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
6
States / cities
San Francisco, California • Tarzana, California • Norwalk, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 11, 2026, 3:36 PM EDT
Recruiting Not applicable Interventional

The Oklahoma Parent-Child Assistance Program

NCT05534568
View directory record Official record
Conditions
Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester, Alcohol Use Complicating Pregnancy, Second Trimester, Alcohol Use Complicating Pregnancy, Third Trimester, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Alcohol Use Complicating Pregnancy, Childbirth, and the Puerperium, Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Drug Use Disorders, Drug Use Complicating Pregnancy, First Trimester, Drug Use Complicating Pregnancy, Second Trimester, Drug Use Complicating Pregnancy, Third Trimester, Drug Use Complicating Pregnancy, Unspecified Trimester, Drug Use Complicating Pregnancy, Childbirth, and the Puerperium, Maternal Drugs Affecting Fetus
Interventions
Parent-Child Assistance Program
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Oklahoma City, Oklahoma • Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 6, 2024 · Synced Sep 11, 2026, 3:36 PM EDT
Completed No phase listed Observational

The CORE Buprenorphine Project - An HIV Primary Care Program Demonstration

NCT00227357
View directory record Official record
Conditions
HIV Infections, AIDS, Opiate Dependence, Post-Traumatic Stress Disorders
Interventions
On-site - buprenorphine/naloxone (Suboxone), Off-site - methadone or no agonist
Drug
Lead sponsor
Ruth M. Rothstein CORE Center
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 6, 2010 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Phase 2 Interventional Results available

Varenicline for Methamphetamine Dependence

NCT01365819
View directory record Official record
Conditions
Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 11, 2026, 3:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients

NCT03377855
View directory record Official record
Conditions
Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency
Interventions
Default Prescribing Change
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 89 Years
Enrollment
948 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Sep 11, 2026, 3:36 PM EDT