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ClinicalTrials.gov public records Last synced Oct 2, 2026, 12:47 AM EDT

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Showing 25–48 of 860 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Abuse Tobacco Clear all
Completed Phase 2 Interventional Accepts healthy volunteers

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

NCT02870218
View directory record Official record
Conditions
Nicotine Addiction, Cigarette Smoking
Interventions
Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
Drug
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2022 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Effects of Vaping Nicotine on Cognition in Young Adults

NCT04901208
View directory record Official record
Conditions
Nicotine Addiction, Vaping
Interventions
Nicotine pod, Placebo pod
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 22, 2024 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vigorous Exercise for Depressed Smokers

NCT01860924
View directory record Official record
Conditions
Nicotine Dependence, Depression
Interventions
exercise, health education
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 2, 2026, 12:47 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior

NCT01636310
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2013 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cessation Screening Project

NCT04188873
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline, Extended Duration Varenicline, Preparation Combination NRT and Standard Duration Combination NRT, Preparation Combination NRT and Extended Duration Combination NRT, Standard Duration Combination NRT, Extended Duration Combination NRT, Intensive Counseling, Minimal Counseling
Drug · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
538 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 4 Interventional Results available

Identifying Optimal Smoking Cessation Intervention Components (Cessation)

NCT01116986
View directory record Official record
Conditions
Smoking, Smoking Cessation, Nicotine Dependence
Interventions
Counseling before quit attempt, Minimal In-person counseling during quit attempt, Intensive in-person counseling during the quit attempt, Minimal phone counseling during the quit attempt, Intensive phone counseling during the quit attempt, Long Term Nicotine Patch+ Nicotine Gum During Quit Attempt, Short Term Nicotine Patch + Nicotine Gum during the quit attempt, Pre-Quit Nicotine Gum, Pre-Quit Nicotine Patch, Pre-Quit Nicotine Patch + Pre-Quit Nicotine Gum
Behavioral · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
637 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 11, 2015 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

LGBT Internet Based Smoking Treatment - 1

NCT00111501
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Tobacco Use Disorder, Standard Web-based intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
792 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2015 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Early Phase 1 Interventional Results available

Pilot Study on Mindfulness for Tobacco and Alcohol in University Students

NCT01679236
View directory record Official record
Conditions
Nicotine Dependence, Alcohol Use
Interventions
Mindfulness Training for Smokers, Interactive Learning for Smokers
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 29 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 24, 2014 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 2 Interventional

Tobacco Approach Avoidance Training for Adolescent Smokers-1

NCT01625767
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
AAT experiment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
13 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 21, 2013 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 2 Interventional

Brief Voluntary Alcohol and Drug Intervention for Middle School Youth

NCT01081119
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
Interventions
Project CHOICE
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 15 Years
Enrollment
6,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2014 · Synced Oct 2, 2026, 12:47 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

NCT06624137
View directory record Official record
Conditions
OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer, Migraine, PTSD, PTSD - Post Traumatic Stress Disorder, Addiction, Tobacco Use Disorder, Obsessive Compulsive Disorder (OCD), Opioid Use Disorder
Interventions
Serotonergic Psychedelic, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Hamden, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Not applicable Interventional Results available

Neural Mechanisms Associated With Risk of Smoking Relapse

NCT02837510
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Standard smoking cessation counseling
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Not applicable Interventional Results available

Switching to Potential Reduced Exposure Products in Adult Smokers

NCT04250727
View directory record Official record
Conditions
Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction, Toxic Effect of Tobacco and Nicotine, Carcinogenesis
Interventions
ZYN
Device
Lead sponsor
Yale University
Other
Eligibility
21 Years to 77 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 2, 2026, 12:47 AM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 2, 2026, 12:47 AM EDT
Terminated Phase 2 Interventional Results available

Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava

NCT05081882
View directory record Official record
Conditions
Smoking
Interventions
Kava, Placebo
Drug
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation

NCT01685996
View directory record Official record
Conditions
Nicotine Dependence
Interventions
zonisamide, placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Oct 2, 2026, 12:47 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers

NCT05044546
View directory record Official record
Conditions
Depression, Tobacco Use Disorder
Interventions
Behavioral Activation Therapy, Discussion, Health Education, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Procedure · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 4 Interventional

C-Raven, a Virtual Tobacco Cessation Intervention in the Community

NCT06545669
View directory record Official record
Conditions
Tobacco Dependence
Interventions
C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening
Behavioral · Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Tobacco Use Disparities Among Low-Income Adults

NCT03077737
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence
Interventions
Choose to Change, Enhanced usual care
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 21, 2022 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 4 Interventional

Bupropion as an Adjunct to the Nicotine Patch Plus CBT

NCT00142831
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Pharmacotherapies for Smoking Cessation
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 65 Years
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD170401: Study to Assess Elements of Abuse Liability for Three Electronic Tobacco Vapor Products During an 11-Day In-Clinic Confinement

NCT03126357
View directory record Official record
Conditions
Smoking
Interventions
Product A, Product B, Product C, Product D, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Oct 2, 2026, 12:47 AM EDT
Completed No phase listed Observational

Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smokers and in Heavy and Light Situational Smokers

NCT01038245
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Maintaining Abstinence in Chronic Cigarette Smokers - 1

NCT00087880
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion and NRT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 2, 2026, 12:47 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Dynamic Assessment and Referral System - Evaluation

NCT01153373
View directory record Official record
Conditions
Smoking, Alcohol Abuse, Drug Abuse
Interventions
Self-administered computerized assessment for tobacco, substance abuse, and alcohol use., Self-Administered Computerized Assessment and Counseling for Tobacco, Alcohol, and Substance Abuse
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
758 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2015 · Synced Oct 2, 2026, 12:47 AM EDT