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ClinicalTrials.gov public records Last synced Oct 4, 2026, 1:21 PM EDT

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Showing 49–72 of 860 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Abuse Tobacco Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarette Use on the Lungs

NCT02596685
View directory record Official record
Conditions
Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions
Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 45 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Working Memory Training on Delay Discounting Among Cigarette Smokers

NCT05210608
View directory record Official record
Conditions
Tobacco Use Disorder/Cigarette Smoking
Interventions
Working Memory Training + Behavioral Intervention
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 4, 2026, 1:21 PM EDT
Not listed Phase 4 Interventional

Safety and Efficacy of the Novel Selective Nicotinic Receptor Partial Agonist, CHANTIX (Varenicline) in Patients With Acute Coronary Syndrome

NCT01170338
View directory record Official record
Conditions
Smoking, Acute Coronary Syndrome
Interventions
Varenicline 100 mg by mouth twice daily, control
Drug
Lead sponsor
Newark Beth Israel Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 27, 2010 · Synced Oct 4, 2026, 1:21 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Use of Nicotine Pouches Among Daily Smokers

NCT06043362
View directory record Official record
Conditions
Tobacco Dependence
Interventions
0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch, Smooth nicotine pouch, Wintergreen nicotine pouch
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Hershey, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Oct 4, 2026, 1:21 PM EDT
Active, not recruiting Phase 4 Interventional

C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics

NCT07220356
View directory record Official record
Conditions
Tobacco Dependence
Interventions
C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening
Behavioral · Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional

Effects of Cigar Flavors on Measures of Abuse Liability Among Young Adults

NCT02937051
View directory record Official record
Conditions
Tobacco Products
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 21 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder

NCT05049460
View directory record Official record
Conditions
Opioid-use Disorder, Tobacco Use Disorder
Interventions
Theta Burst Stimulation, Sham TMS
Device
Lead sponsor
Gopalkumar Rakesh
Other
Eligibility
18 Years to 60 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 4, 2026, 1:21 PM EDT
Withdrawn Phase 1 Interventional

Trial of Computerized SBI to Reduce Teen Alcohol Use

NCT01784627
View directory record Official record
Conditions
Alcohol Abuse, Cannabis Abuse, Nicotine Dependence
Interventions
c-ASBI
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
9 Years to 20 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
6
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Lexington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2016 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional

Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

NCT03904186
View directory record Official record
Conditions
Human Immunodeficiency Virus, Smoking Cessation, Smoking, Cigarette, Smoking, Anxiety, Depression, Nicotine Dependence
Interventions
QUIT, Time-Matched Control (TM)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
3
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 4, 2026, 1:21 PM EDT
Terminated Phase 3 Interventional Results available

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

NCT01169610
View directory record Official record
Conditions
Alcoholism, Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 4, 2026, 1:21 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treating Smokeless Tobacco Use in Rural Veterans

NCT02994082
View directory record Official record
Conditions
Smokeless Tobacco, Nicotine Dependence
Interventions
Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials
Behavioral · Drug
Lead sponsor
Mark Vander Weg
Federal
Eligibility
18 Years to 99 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Innovative Digital Therapeutic for Smoking Cessation

NCT03694327
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence, Tobacco Dependence, Tobacco Use Disorder, Substance Use Disorder, Tobacco Smoking
Interventions
CT-101-M, QuitGuide
Device
Lead sponsor
My Digital Study
Industry
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

NCT04461288
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 4, 2026, 1:21 PM EDT
Recruiting Not applicable Interventional

Neuroimaging of Adolescent Cannabis Use Treatment

NCT07340554
View directory record Official record
Conditions
Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Phase 1 Interventional

Nicotine Differences in Smokers

NCT05159934
View directory record Official record
Conditions
Nicotine Dependence
Interventions
0.05, 0.025, and 0.0125 mg nicotine/pulse of nicotine, Saline
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Phase 1 Interventional Results available

Developing a Smoking Cessation Intervention for Methadone Maintained Smokers

NCT01393392
View directory record Official record
Conditions
Nicotine Dependence, Opiate Dependence
Interventions
Intensive, tailored intervention, NJ Quitline Referral
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Early Phase 1 Interventional

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

NCT06602492
View directory record Official record
Conditions
Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions
Lower nicotine e-liquid, Higher nicotine eliquid
Drug
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Varenicline and Combined NRT for Smoking Cessation

NCT02271919
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Nicotine Lozenge, Nicotine Patch, Placebo, Tobacco Cessation Counseling, Varenicline
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
631 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Do Flavors Increase the Addiction Potential of Nicotine?

NCT04696380
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, JUUL e-cigarette
Drug · Device
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Oct 4, 2026, 1:21 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

NCT05181891
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Nicotine Use Disorder
Interventions
Contingency Management, Non-contingent control
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Yoga as a Complementary Therapy for Smoking Cessation

NCT01809678
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Smoking Cessation, Yoga, Wellness
Behavioral · Other
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
255 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Oct 4, 2026, 1:21 PM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

NCT00419731
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion, Bupropion + Naltrexone
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 3, 2009 · Synced Oct 4, 2026, 1:21 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt

NCT00571805
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varencline, placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2015 · Synced Oct 4, 2026, 1:21 PM EDT
Completed Not applicable Interventional Results available

Varenicline and Motivational Advice for Smokers With Substance Use Disorders

NCT00756275
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 4, 2026, 1:21 PM EDT