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Showing 1–24 of 164 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Acceptance and Commitment Therapy Clear all
Completed Not applicable Interventional

Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder

NCT02750904
View directory record Official record
Conditions
Smoking, Bipolar Disorder
Interventions
Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
4
States / cities
Palo Alto, California • Denver, Colorado • Bedford, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2019 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating an Online Acceptance and Commitment Training Program for Individuals with Chronic Health Conditions

NCT06179264
View directory record Official record
Conditions
Stress, Psychological, Depression, Well-Being, Psychological
Interventions
ACT Guide for Chronic Health Conditions
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional

A Guided Online ACT Intervention Combined With Psychoeducation for People With Spinal Cord Injury

NCT04670406
View directory record Official record
Conditions
Spinal Cord Injuries, Psychological Distress
Interventions
acceptance and commitment therapy (ACT) combined with psychoeducation
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 7, 2021 · Synced Sep 20, 2026, 9:55 AM EDT
Completed No phase listed Observational

COMPASS: A Group ACT Program for Cancer Patients Treated at UCSF

NCT04636346
View directory record Official record
Conditions
Cancer
Interventions
Acceptance and Commitment Therapy, Questionnaires
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 20, 2026, 9:55 AM EDT
Not listed Not applicable Interventional

ACT and CBT Bibliotherapy for Perfectionism

NCT06057740
View directory record Official record
Conditions
Perfectionism
Interventions
Acceptance and commitment therapy (ACT), Cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 20, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional

Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

NCT05540704
View directory record Official record
Conditions
Type 1 Diabetes, Eating Disorders, Disordered Eating Behaviors, Purging (Eating Disorders), Binge-Eating Disorder
Interventions
ACT, Supportive Diabetes Counseling
Behavioral
Lead sponsor
Duke University
Other
Eligibility
16 Years to 50 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Durham, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Not yet recruiting Not applicable Interventional

Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough

NCT07566117
View directory record Official record
Conditions
Chronic Cough
Interventions
Acceptance and Commitment Therapy (ACT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional Results available

Acceptance and Commitment Therapy to Improve Social Support for Veterans With PTSD

NCT04567680
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD, Present-Centered Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Aurora, Colorado • West Haven, Connecticut • Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy Delivered by Automated Software Messaging

NCT04329897
View directory record Official record
Conditions
Hip Osteoarthritis, Knee Osteoarthritis, Mental Stress, Coronavirus
Interventions
Software Messaging
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Sep 20, 2026, 9:55 AM EDT
Active, not recruiting Not applicable Interventional

Pursuing Exploration Into the Supportive Care Needs and Intervention Preferences of Survivors of Testicular Cancer

NCT07228637
View directory record Official record
Conditions
Testicular Cancer
Interventions
Acceptance and Commitment Therapy (ACT) Coaching, Education and Support Coaching
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional

Treating Pain With Acceptance and Commitment Therapy Trial

NCT03666455
View directory record Official record
Conditions
Acceptance and Commitment Therapy, Chronic Pain, Opioid Use
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
4
States / cities
Kansas City, Kansas • Lexington, Kentucky • Albuquerque, New Mexico + 1 more
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ACT with NMOSD Patients and Caregivers Pilot Study

NCT05840055
View directory record Official record
Conditions
NMO Spectrum Disorder
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Sep 20, 2026, 9:55 AM EDT
Suspended Not applicable Interventional

Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD)

NCT05457790
View directory record Official record
Conditions
Sickle Cell Disease, Sickle Cell Anemia, Insomnia, Sleeplessness, Transient Insomnia, Nonorganic Insomnia, Chronic Insomnia
Interventions
ACT Intervention, Waitlist
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 55 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional Results available

Acceptance and Commitment Therapy (ACT) for OEF/OIF Veterans

NCT01253044
View directory record Official record
Conditions
Distress, Anxiety, Depression, Postconcussive Symptoms
Interventions
Acceptance and Commitment Therapy, Present Centered Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
6
States / cities
La Jolla, California • Washington D.C., District of Columbia • Augusta, Maine + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2015 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional Results available

Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss

NCT04337619
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Behavioral Treatment, Willingness, Values, Mindful Awareness
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 70 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional

CARED : A Novel Rapid Treatment Paradigm for Depression

NCT07507370
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy, Sham (Placebo) Transcranial Alternating Current Stimulation (tACS)
Device · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Minority Stress Counseling for LGBTQ+ Individuals

NCT06614868
View directory record Official record
Conditions
Minority Stress
Interventions
Acceptance and Commitment Therapy, Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Not yet recruiting Not applicable Interventional

Comparing Two Moral Injury Treatments

NCT07710521
View directory record Official record
Conditions
Moral Injury
Interventions
Acceptance and Commitment Therapy for Moral Injury (ACT-MI), Present Centered Therapy for Moral Injury (PCT-MI)
Behavioral
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 89 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

NCT05361811
View directory record Official record
Conditions
Neurofibromatosis 1, Noonan Syndrome, Legius Syndrome, Cardiofaciocutaneous Syndrome, Costello Syndrome
Interventions
Waitlist, ACT Intervention
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional

Evaluation of an Acceptance and Commitment Therapy-Based Narrative Intervention for Individuals Taking Antidepressants

NCT04757961
View directory record Official record
Conditions
Depressive Symptoms
Interventions
LifeStories
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Acceptance and Commitment Therapy for the Inpatient Treatment of Psychosis

NCT01981356
View directory record Official record
Conditions
Psychotic Disorders
Interventions
Acceptance and Commitment Therapy, Treatment as Usual (TAU)
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 99 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2016 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional

PREventing Pain After Surgery

NCT05306665
View directory record Official record
Conditions
Pain, Back, Spinal Stenosis, Disc Herniation, Spondylosis, Spondylolisthesis, Back Injuries
Interventions
ACT intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
22 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 20, 2026, 9:55 AM EDT
Completed Not applicable Interventional

Open Trial to Improve Retention in Care for Persons With HIV Who Use Substances

NCT05101044
View directory record Official record
Conditions
Substance Use Disorders, Hiv
Interventions
Acceptance-based Behavioral Therapy (ABBT) Intervention
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 20, 2026, 9:55 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

TANDem-2: Closing the Gap to Interventions for TAND

NCT06879665
View directory record Official record
Conditions
Adult Caregivers of Individuals With TSC, Tuberous Sclerosis Complex (TSC)
Interventions
Well-Beans for Caregivers Program
Behavioral
Lead sponsor
Vrije Universiteit Brussel
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Sep 20, 2026, 9:55 AM EDT