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Showing 1–24 of 162 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Acceptance and Commitment Therapy Clear all
Completed Not applicable Interventional Results available

Brief Behavioral Intervention for Comorbid Migraine and Depression

NCT01775852
View directory record Official record
Conditions
Migraine, Depression
Interventions
ACT-IM
Behavioral
Lead sponsor
Lilian N. Dindo
Other
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Innovative Approach to Reduce Lung Cancer Stigma

NCT03750864
View directory record Official record
Conditions
Lung Cancer Stigma, Lung Cancer, Stigma, Social, Stigmatization, Acceptance Processes
Interventions
ACT-LCS Therapy
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Tucson, Arizona • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2022 · Synced Jul 21, 2026, 4:04 PM EDT
Active, not recruiting Not applicable Interventional

Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment

NCT05039554
View directory record Official record
Conditions
Opioid-use Disorder, Chronic Pain
Interventions
Acceptance and commitment therapy, Valera Smartphone Application, Treatment as Usual
Behavioral · Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Investigating Two Prototype Mobile App Interventions to Increase Physical Activity

NCT06372275
View directory record Official record
Conditions
Health-Related Behavior
Interventions
Values Clarification Mobile Application, Self-Reflection Mobile Application
Behavioral
Lead sponsor
Mississippi State University
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Starkville, Mississippi
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss

NCT04337619
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Behavioral Treatment, Willingness, Values, Mindful Awareness
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 70 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Suspended Not applicable Interventional

Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD)

NCT05457790
View directory record Official record
Conditions
Sickle Cell Disease, Sickle Cell Anemia, Insomnia, Sleeplessness, Transient Insomnia, Nonorganic Insomnia, Chronic Insomnia
Interventions
ACT Intervention, Waitlist
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 55 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional

Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

NCT05540704
View directory record Official record
Conditions
Type 1 Diabetes, Eating Disorders, Disordered Eating Behaviors, Purging (Eating Disorders), Binge-Eating Disorder
Interventions
ACT, Supportive Diabetes Counseling
Behavioral
Lead sponsor
Duke University
Other
Eligibility
16 Years to 50 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Durham, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 1 Interventional

Family Treatment for Adolescents With Anorexia Nervosa

NCT01280799
View directory record Official record
Conditions
Anorexia Nervosa, Subthreshold Anorexia Nervosa, Eating Disorder Not Otherwise Specified, Primarily Restriction
Interventions
Acceptance-based separated family treatment
Behavioral
Lead sponsor
Towson University
Other
Eligibility
12 Years to 18 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
2
States / cities
Durham, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 18, 2014 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Family Caregivers of People With Dementia

NCT04458870
View directory record Official record
Conditions
Psychological Distress
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Jul 21, 2026, 4:04 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Virtual ACT for Adolescent Stress

NCT04978610
View directory record Official record
Conditions
Chronic Illness
Interventions
Virtual Acceptance Commitment Therapy
Behavioral
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy for Adolescents and Young Adults With Neurofibromatosis and Chronic Pain

NCT01633008
View directory record Official record
Conditions
Neurofibromatosis
Interventions
ACT Workshop
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
12 Years to 99 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2019 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

One-Day Intervention for Depression and Impairment in Migraine Patients

NCT02108678
View directory record Official record
Conditions
Migraine, Depression
Interventions
ACT-ME, Migraine Education Only
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 21, 2017 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Pain and Narcotic Usage After Orthopaedic Surgery

NCT03991546
View directory record Official record
Conditions
Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute, Analgesia, Opioid Use, Acceptance and Commitment Therapy, Orthopedics, Analgesics, Opioid, Text Messaging
Interventions
Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot
Behavioral
Lead sponsor
Christopher Anthony
Other
Eligibility
18 Years to 100 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Acceptance and Commitment Therapy (ACT) and Cognitive Therapy (CT) for Test Anxiety

NCT00850226
View directory record Official record
Conditions
Anxiety
Interventions
CT, ACT
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2010 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

Acceptance and Commitment Therapy (ACT) for OEF/OIF Veterans

NCT01253044
View directory record Official record
Conditions
Distress, Anxiety, Depression, Postconcussive Symptoms
Interventions
Acceptance and Commitment Therapy, Present Centered Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
6
States / cities
La Jolla, California • Washington D.C., District of Columbia • Augusta, Maine + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2015 · Synced Jul 21, 2026, 4:04 PM EDT
Active, not recruiting Early Phase 1 Interventional

Smoking Cessation Treatment for Head & Neck Cancer Patients

NCT01098955
View directory record Official record
Conditions
Head and Neck Cancer, Smoking Cessation
Interventions
Acceptance and Commitment Therapy, Motivational and Behavioral Counseling, Varenicline
Behavioral · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Understanding Medication Adherence Among HIV Patients

NCT01305590
View directory record Official record
Conditions
Patient Commitment Preferences for Medication Adherence
Interventions
Survey to Understand Medication Adherence among HIV Patients
Other
Lead sponsor
National Bureau of Economic Research, Inc.
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Jul 21, 2026, 4:04 PM EDT
Completed No phase listed Observational

Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention

NCT06168825
View directory record Official record
Conditions
Cancer, Breast Cancer, Brain Cancer, Central Nervous System Cancer, Colorectal Cancer, Esophageal Cancer, Gynecologic Cancer, Head and Neck Cancer, Gastrointestinal Cancer, Genitourinary Cancer, Melanoma, Blood Cancer, Lung Cancer, Acceptance and Commitment Therapy, Mind-Body Therapies, Psychosocial Intervention
Interventions
Mind Over Matter (MOM)
Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Increasing Access to Evidence-based Treatment for Chronic Pain and Opioid Use Disorder: Adapting Acceptance and Commitment Therapy for Opioid Treatment Programs

NCT06581276
View directory record Official record
Conditions
Opioid Use, Opioid Use Disorder, Chronic Pain
Interventions
Acceptance and Commitment Therapy (ACT)
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy Delivered by Automated Software Messaging

NCT04329897
View directory record Official record
Conditions
Hip Osteoarthritis, Knee Osteoarthritis, Mental Stress, Coronavirus
Interventions
Software Messaging
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy vs. Supportive Psychotherapy With Cystic Fibrosis Patients

NCT04114227
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Acceptance and Commitment Therapy adapted for Cystic Fibrosis (ACT with CF), Supportive Psychotherapy (Treatment as Usual Control)
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2024 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy

NCT05427201
View directory record Official record
Conditions
Chronic Pain, Depression
Interventions
Repetitive Transcranial Magnetic Stimulation, Acceptance and Commitment Therapy
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Not listed Not applicable Interventional

ACT and CBT Bibliotherapy for Perfectionism

NCT06057740
View directory record Official record
Conditions
Perfectionism
Interventions
Acceptance and commitment therapy (ACT), Cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Nonsuicidal Self-injury

NCT03548402
View directory record Official record
Conditions
Nonsuicidal Self-Injury, Anxiety
Interventions
Acceptance and Commitment Therapy (ACT)
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Jul 21, 2026, 4:04 PM EDT