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Showing 73–96 of 161 matching trials from the live ClinicalTrials.gov search.
Conditions
Mitochondrial Enzyme Deficiencies
Interventions
Dichloroacetate
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Gainesville, Florida
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones

NCT05778695
Conditions
Parkinson Disease, Lewy Body Dementia, Parkinson Disease Dementia
Interventions
Ketone Ester (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
45 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Ann Arbor, Michigan
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
ketone ester, placebo
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Chronic Daily Headache
Interventions
Modified Atkins diet
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 19 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Not listed Not applicable Interventional Accepts healthy volunteers

Scanadu Urine Device Validation Study Protocol

NCT02973178
Conditions
Urinary Tract Infections, Proteinuria, Ketone Urine, Hematuria, Glucose Intolerance
Interventions
Scanadu Urine Device
Device
Lead sponsor
Scanadu, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Mountain View, California • San Leandro, California
Completed Phase 2Phase 3 Interventional Results available

Alkali Therapy in Chronic Kidney Disease

NCT01452412
Conditions
Chronic Kidney Disease, Metabolic Acidosis
Interventions
Sodium bicarbonate, Placebo
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
19 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
The Bronx, New York • Cleveland, Ohio
Conditions
Epilepsy
Interventions
Modified Atkins diet
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
3 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Obesity, Appetite, Healthy Volunteers
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 50 Years · Male only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Diabetic Ketoacidosis
Interventions
Continuous Glucose Monitoring (CGM), Standard of Care
Device · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Metabolic Acidosis, Acute Kidney Injury, Acute Kidney Failure
Interventions
Low bicarbonate solution (22 mmol/L), High Bicarbonate solution (32 mmol/L)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Recruiting Not applicable Interventional

Nutrition for Asthmatics

NCT06151405
Conditions
Asthma
Interventions
DGA Diet, MCT Diet, KETO Diet
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Conditions
Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
Interventions
Kenetik; Ketone Concentrate, Isocaloric dextrose placebo
Dietary Supplement
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Wernersville, Pennsylvania
Conditions
Alzheimer's Disease
Interventions
caprylic triglyceride, long-chain triglyceride
Drug
Lead sponsor
Cerecin
Industry
Eligibility
55 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
St. Petersburg, Florida
Recruiting Early Phase 1 Interventional

Ketones, SGLT2, HFrEF

NCT06229678
Conditions
Type2diabetes, Heart Failure With Reduced Ejection Fraction
Interventions
Empagliflozin 25 MG Oral Tablet, Placebo, Acipimox 250 Mg Oral Capsule
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Completed No phase listed Observational Accepts healthy volunteers

StatStrip Glucose/Ketone Meter System Ketone Evaluation

NCT05118061
Conditions
Diabetes Mellitus, Ketosis, Diabetic
Interventions
Ketone
Diagnostic Test
Lead sponsor
Nova Biomedical
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Medley, Florida
Withdrawn Not applicable Interventional Accepts healthy volunteers

Time Course for Fasting-induced Autophagy in Humans

NCT04842864
Conditions
Fasting, Autophagy, Aging Well, Ketosis, Metabolic
Interventions
Fasting
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Conditions
Cerebral Edema, Diabetic Ketoacidosis
Interventions
0.45% saline replacement fluid, 0.9% saline replacement fluid, 0.45% saline intravenous fluid, 0.9% saline Intravenous fluid
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 17 Years
Enrollment
1,389 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
13
States / cities
Sacramento, California • Aurora, Colorado • Wilmington, Delaware + 10 more
Conditions
Type2 Diabetes, Heart Failure With Preserved Ejection Fraction
Interventions
Empagliflozin 25 MG, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Conditions
Mitochondrial Diseases
Interventions
Cysteamine Bitartrate
Drug
Lead sponsor
Amgen
Industry
Eligibility
6 Years to 17 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
5
States / cities
San Diego, California • Stanford, California • Akron, Ohio + 2 more
Completed Not applicable Interventional Accepts healthy volunteers

Enhanced vs. Routine Clear Liquid Intake in Labor

NCT02524002
Conditions
Abnormal Labor, Failed Induction of Labor, Ketosis
Interventions
Accel Gel, Usual clear diet
Dietary Supplement
Lead sponsor
Temple University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Diabetic Ketoacidosis
Interventions
200mg IV thiamine in 50mL 0.9% saline, Placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Phase 1 Interventional Results available

Ketone Pharmacokinetic Study in HFrEF

NCT05757193
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
DeltaG (250 mg/kg), DeltaG (500 mg/kg)
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Metabolic Acidosis, Chronic Kidney Disease
Interventions
TRC101, Placebo
Drug
Lead sponsor
Tricida, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
20
States / cities
Azusa, California • Denver, Colorado • Boca Raton, Florida + 16 more
Conditions
Evaluate Ketogenic Stress
Interventions
Exenatide/Exenatide extended release, Dapagliflozin, Placebo
Drug
Lead sponsor
University at Buffalo
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Williamsville, New York