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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Active Smoker Clear all
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Varenicline Treatment for Active Alcoholic Smokers

NCT01347112
View directory record Official record
Conditions
Smoking, Tobacco Dependence, Alcohol Dependence
Interventions
Varenicline, placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
2
States / cities
Rochester, Minnesota • La Crosse, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Jun 11, 2026, 2:54 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of a Specific Substance in Smokers

NCT04281979
View directory record Official record
Conditions
Smoking
Interventions
Study Agent, Placebo
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jun 11, 2026, 2:54 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation

NCT02662075
View directory record Official record
Conditions
Smoking
Interventions
E-cigarette/tobacco Smoking Exposure
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 26, 2017 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Phase 1 Interventional

Investigation of Nicotine Seeking Behavior in Current Smokers

NCT03670212
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Yohimbine Hydrochloride, Hydrocortisone, Lactose Monohydrate Powder
Drug
Lead sponsor
Wayne State University
Other
Eligibility
21 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vigorous Exercise for Depressed Smokers

NCT01860924
View directory record Official record
Conditions
Nicotine Dependence, Depression
Interventions
exercise, health education
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Jun 11, 2026, 2:54 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Physical Activity in Promoting Smoking Cessation in African Americans

NCT01915810
View directory record Official record
Conditions
Current Smoker, Healthy Subject
Interventions
Exercise Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 11, 2026, 2:54 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Step-up to Quit: Using Low-to-moderate Intensity Exercise for Reducing Smoking Cue Reactivity Among Low-income Smokers

NCT02220465
View directory record Official record
Conditions
Sedentary Lifestyle, Cigarette Smoking
Interventions
PA+ Smoking Cessation (LMPA), Standard Care Smoking Counseling (SCC)
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 59 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers

NCT01337817
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva Silver Wintergreen, Ariva Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Jun 11, 2026, 2:54 AM EDT
Completed No phase listed Observational

NK Cell Activity in Smokers Screened for Lung Cancer

NCT02840578
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
University of Southern California
Other
Eligibility
50 Years to 80 Years
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Not applicable Interventional

Exercise for Depressed Smokers

NCT02086149
View directory record Official record
Conditions
Tobacco Smoking, Smoking Cessation
Interventions
Aerobic Exercise, Health Education
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Jun 11, 2026, 2:54 AM EDT
Recruiting Not applicable Interventional

Identify the Optimal TMS Target to Modulate Reward Activity

NCT05766254
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Active 10-Hz TMS to the DLPFC, Sham TMS-DLPFC
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Not applicable Interventional Results available

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

NCT02873754
View directory record Official record
Conditions
Smoking
Interventions
Cognitive Behavioral Counseling, Mobile Contingency Management, Bupropion, Transdermal nicotine patch, Nicotine polacrilex, Nicotine lozenge
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Solarplast® on Immunity in Active Smokers and Non-smokers

NCT05162820
View directory record Official record
Conditions
Immunity, Smoking, Cigarette
Interventions
100 mg Solarplast, Placebo
Dietary Supplement
Lead sponsor
University of Memphis
Other
Eligibility
30 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Jun 11, 2026, 2:54 AM EDT
Active, not recruiting Not applicable Interventional

Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules

NCT04574518
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Tobacco Use
Interventions
TeaM OUT Intervention, Enhanced Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Minneapolis, Minnesota • Portland, Oregon • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 11, 2026, 2:54 AM EDT
Withdrawn No phase listed Observational

Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients

NCT01809730
View directory record Official record
Conditions
Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency, Diabetes, COPD, Hypertension, Active Smoker, Cancer, CHF, Prior DVT/PE
Interventions
Not listed
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Jun 11, 2026, 2:54 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers

NCT01262170
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
CigRx Lozenge, Tobacco Lozenge
Dietary Supplement · Other
Lead sponsor
Rock Creek Pharmaceuticals, Inc.
Industry
Eligibility
23 Years to 72 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2015 · Synced Jun 11, 2026, 2:54 AM EDT