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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Acute Arterial Ischemic Stroke Clear all
Recruiting Not applicable Interventional

Pulse Endovascular ReperFUSION for Acute Ischemic Stroke

NCT06052969
View directory record Official record
Conditions
Acute Ischemic Stroke AIS, Cerebral Arterial Disease
Interventions
Pulse NanoMED System
Device
Lead sponsor
Euphrates Vascular, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jul 23, 2026, 10:15 AM EDT
Not listed Phase 2 Interventional

Reversal of the Neurological Deficit in Acute Stroke With the Signal of Efficacy Trial of Auto BPAP to Limit Damage From Suspected Sleep Apnea

NCT01812993
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Non-invasive ventilatory treatment with auto-BPAP
Device
Lead sponsor
Technische Universität Dresden
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 11, 2015 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke

NCT01584609
View directory record Official record
Conditions
Acute Ischemic Stroke From Large Vessel Occlusion
Interventions
Penumbra System with Separator 3D, Penumbra System alone
Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
8
States / cities
Newport Beach, California • Denver, Colorado • Hartford, Connecticut + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Millipede AspiRation for Revascularization in Stroke (MARRS) Study

NCT05714501
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Millipede System
Device
Lead sponsor
Perfuze
Industry
Eligibility
18 Years to 85 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
15
States / cities
New Haven, Connecticut • Jacksonville, Florida • Tampa, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 23, 2026, 10:15 AM EDT
Withdrawn Phase 2 Interventional

REGENESIS (US): A Phase IIb Prospective, Randomized, Double-blind, Placebo Controlled Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients

NCT00715364
View directory record Official record
Conditions
Stroke
Interventions
NTx™-265: rhCG, then rEPO, Saline Placebo
Drug
Lead sponsor
Stem Cell Therapeutics Corp.
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Newport Beach, California • Orange, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2011 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 2 Interventional Results available

Mayo Acute Stroke Trial for Enhancing Recovery

NCT00805792
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Donepezil
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2021 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Effects of YM872 on Stroke Lesion Volume in Acute Stroke Patients

NCT00044070
View directory record Official record
Conditions
Cerebrovascular Accident
Interventions
YM872 (zonampanel)
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2003
U.S. locations
60
States / cities
Mobile, Alabama • Phoenix, Arizona • Tucson, Arizona + 53 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2006 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 2 Interventional Results available

Histamine Glutamate Antagonism in Stroke

NCT02142712
View directory record Official record
Conditions
Acute Cerebrovascular Accident, Cerebral Edema
Interventions
Diphenhydramine, Pantoprazole, Famotidine, Dextromethorphan
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 14, 2015 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 2 Interventional

Continuous Positive Airway Pressure for the Treatment of Stroke

NCT00368628
View directory record Official record
Conditions
Acute Ischemic Stroke, Sleep Apnea
Interventions
continuous positive airway pressure
Procedure
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 2, 2009 · Synced Jul 23, 2026, 10:15 AM EDT
Completed No phase listed Observational

Posterior cerebraL ArTery Occlusion Study

NCT05291637
View directory record Official record
Conditions
Stroke, Acute Ischemic
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
1,282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
9
States / cities
Miami, Florida • Atlanta, Georgia • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stroke and Traumatic Acute Brain Injury Line Indicator System for Emergent Recognition (STABILISER-I)

NCT02514902
View directory record Official record
Conditions
Ischemic Stroke, Hemorrhagic Stroke, Traumatic Brain Injury
Interventions
Lateral Flow Device
Device
Lead sponsor
Justin Fraser
Other
Eligibility
21 Years to 85 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention With Trevo

NCT02142283
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Trevo Thrombectomy Procedure, Medical Management
Device · Other
Lead sponsor
Stryker Neurovascular
Industry
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
24
States / cities
Los Angeles, California • San Francisco, California • Newark, Delaware + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2018 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 3 Interventional

Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke

NCT00061022
View directory record Official record
Conditions
Cerebral Stroke, Stroke, Acute, Cerebrovascular Stroke, Ischemic Attack, Transient
Interventions
NXY-059
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years and older
Enrollment
3,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
98
States / cities
Birmingham, Alabama • Phoenix, Arizona • Fort Smith, Arkansas + 95 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2010 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Deep Learning Enabled Endovascular Stroke Therapy Screening in Community Hospitals

NCT05838456
View directory record Official record
Conditions
Acute Ischemic Stroke (AIS)
Interventions
Viz.AI software
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
443 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Jul 23, 2026, 10:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke

NCT03990545
View directory record Official record
Conditions
Intracranial Atherosclerosis, Acute Stroke, Transient Ischemic Attack
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 100 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Jul 23, 2026, 10:15 AM EDT
Completed No phase listed Observational

Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology

NCT03148340
View directory record Official record
Conditions
Stroke, Stroke, Acute, Ischemic Stroke, Hemorrhage, Clot (Blood); Brain, Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage, Cerebral Stroke, Intracerebral Hemorrhage, Intracerebral Injury
Interventions
VIPS Monitoring
Diagnostic Test
Lead sponsor
Cerebrotech Medical Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
287 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
5
States / cities
Jacksonville, Florida • Buffalo, New York • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 2 Interventional Results available

Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2

NCT01976936
View directory record Official record
Conditions
Stroke, Rhabdomyolysis, Jaundice
Interventions
Low Dose Lovastatin, Placebo, High Dose Lovastatin
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
7
States / cities
Los Angeles, California • Miami, Florida • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2025 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 3 Interventional Results available

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

NCT01369069
View directory record Official record
Conditions
Acute Ischemic Stroke, Diabetes, Hyperglycemia
Interventions
IV insulin to maintain target glucose concentration of 80-130 mg/dL, Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
1,151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
70
States / cities
Tucson, Arizona • Long Beach, California • Los Angeles, California + 45 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2019 · Synced Jul 23, 2026, 10:15 AM EDT
Terminated Not applicable Interventional Results available

Transcranial Direct Current Stimulation as a Neuroprotection in Acute Stroke Before and After Thrombectomy

NCT04061577
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Jul 23, 2026, 10:15 AM EDT
Completed Phase 2 Interventional

Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke

NCT04918719
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Acetylcysteine, Dextrose in Water
Drug
Lead sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jul 23, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

Non-standardized vs. Standardized Screening for Dysphagia

NCT05603897
View directory record Official record
Conditions
Dysphagia
Interventions
Mann Assessment of Swallowing Ability (MASA) (dysphagia screening tool), Non-standardized clinical swallow evaluation
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 23, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

RIsE Stroke Mobility Study

NCT07638462
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
activPAL device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 23, 2026, 10:15 AM EDT
Completed No phase listed Observational

Macrowire for IntracraNial Thrombectomy

NCT06148675
View directory record Official record
Conditions
Stroke, Acute Ischemic
Interventions
No Intervention
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 85 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 23, 2026, 10:15 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Identification of microRNAs Involved in Cerebral Collateral Regulation

NCT03905434
View directory record Official record
Conditions
Cerebrovascular Disorders
Interventions
miRNA sampling
Genetic
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
2
States / cities
Columbus, Ohio • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 23, 2026, 10:15 AM EDT