Interventional Management of Stroke (IMS) III Trial
Public ClinicalTrials.gov record NCT00359424. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Interventional Management of Stroke Trial (IMS III): A Phase III Clinical Trial Examining Whether a Combined Intravenous (IV) and Intra-Arterial (IA) Approach to Recanalization is Superior to Standard IV Rt-PA (Activase®) Alone
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare two different treatment approaches to recanalization started within 3 hours of symptom onset-combined intravenous (IV) and endovascular therapy and standard intravenous (IV) rt-PA alone.
Study identification
- NCT ID
- NCT00359424
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 656 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 82 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2006 (Type not available)
- Primary completion
- Jul 2012 (Actual)
- Completion
- Apr 2013 (Actual)
- Last update posted
- Dec 13, 2013
2006 – 2013
United States locations
- U.S. sites
- 49
- U.S. states
- 23
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | 35294 | — |
| Barrow Neurology Clinics at St. Joseph's Hospital and Medical Center, 222 W. Thomas Road, Suite 404 | Phoenix | Arizona | 85013 | — |
| Mayo Clinic Arizona, 5777 E. Mayo Blvd. | Scottsdale | Arizona | 85054 | — |
| UCLA Medical Center, 924 Westwood Blvd., Suite 300 | Los Angeles | California | 90024 | — |
| Hoag Memorial Hospital | Newport Beach | California | 92658 | — |
| Santa Monica-UCLA Medical Center, 1250 16th Street | Santa Monica | California | 90404 | — |
| Colorado Neurological Institute, Swedish Medical Center, 501 E. Hampden Ave. | Englewood | Colorado | 80113-2771 | — |
| Stroke Center at Hartford, 80 Seymour St. Rm JB603 | Hartford | Connecticut | 06102 | — |
| Morton Plant Mease Health Care, 300 Pinellas Street MS 49 | Clearwater | Florida | 33756 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Alexian Brothers Medical Center, 800 Biesterfield Rd. | Elk Grove Village | Illinois | 60007 | — |
| Ruan Neurological Mercy Medical Center, 1111 6th Ave., Ste. 400 | Des Moines | Iowa | 50314 | — |
| St. Elizabeth Medical Center South, One Medical Village Drive | Edgewood | Kentucky | 41017 | — |
| St Luke's West Hospital, 7380 Turfway Rd. | Florence | Kentucky | 41042 | — |
| St. Luke's Hospital East, 85 N. Grand Ave. | Fort Thomas | Kentucky | 41075 | — |
| University of Louisville, Kentucky Neuroscience Research, Stroke Research, 401 East Chestnut Street, Suite 520 | Louisville | Kentucky | 40202 | — |
| Johns Hopkins University, 1500 Orleans St. 3M South | Baltimore | Maryland | 21231 | — |
| Massachusetts General Hospital, 55 Fruit Street | Boston | Massachusetts | 02114 | — |
| Lahey Clinic Medical Center | Burlington | Massachusetts | 01805 | — |
| Henry Ford Hospital, 2799 W Grand Blvd, CFP-260 | Detroit | Michigan | 48202 | — |
| Michigan State University, Sparrow Hospital, B 401 Clinical Center | East Lansing | Michigan | 48824 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Washington University/Barnes Jewish Hospital, 660 S. Euclid Avenue | St Louis | Missouri | 63110 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Suny Upstate Medical University | Syracuse | New York | 13210 | — |
| Mission Hospital, 509 Biltmore Avenue | Asheville | North Carolina | 28801 | — |
| University of North Carolina, CB # 7025, 7003 Neurosciences Hospital, 7th Floor | Chapel Hill | North Carolina | 27599 | — |
| The Christ Hospital, 2139 Auburn Ave. | Cincinnati | Ohio | 45219 | — |
| The University Hospital, 234 Goodman Ave. | Cincinnati | Ohio | 45219 | — |
| Good Samaritan Hospital, 375 Dixmyth Ave. | Cincinnati | Ohio | 45220-2489 | — |
| The Jewish Hospital of Cincinnati, 4777 East Galbraith Rd | Cincinnati | Ohio | 45236 | — |
| Mercy Hospital, Western Hills, 3131 Queen City Ave. | Cincinnati | Ohio | 45238 | — |
| Mercy Hospital, Mt Airy, 2446 Kipling Ave. | Cincinnati | Ohio | 45239 | — |
| Mercy Hospital Anderson, 7500 State Rd | Cincinnati | Ohio | 45255 | — |
| University Hospitals of Cleveland, Case Western Reserve University,Case Western Neurological Unit, 11100 Euclid Avenue, Lakeside 5508 | Cleveland | Ohio | 44106 | — |
| Riverside Methodist Hospital, 3535 Olentangy River Road | Columbus | Ohio | 43214 | — |
| Mercy Hospital Fairfield, 3000 Mack Rd. | Fairfield | Ohio | 45014 | — |
| Bethesda North Hospital, 10500 Montgomery Rd. | Montgomery | Ohio | 45242 | — |
| OHSU, Oregon Stroke Center, Providence St. Vincent's Hospital, Providence Portland Hospital | Portland | Oregon | 97239 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Lehigh Valley Hospital Center, 1200 South Cedar Crest Blvd. | Allentown | Pennsylvania | 18103 | — |
| PENN State M.S. Hershey Medical Center, 500 University Drive MC: HS 86, Long Lane Rom HG:212 | Hershey | Pennsylvania | 17033 | — |
| Allegheny General Hospital, 420 East North Avenue, East Wing Office Bldg., Suite 206 | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh, Medical Center, 200 Lothrop Street, PUH C-400 | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| University Medical Center at Brackenridge Hospital | Austin | Texas | 78701 | — |
| University of Texas Medical School at Houston, 6431 Fannin, MSB 7.044 | Houston | Texas | 77030 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| Froedtert Hospital, Medical College of Wisconsin, 9200 W. Wisconsin Avenue | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00359424, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 13, 2013 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00359424 live on ClinicalTrials.gov.