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Showing 1–24 of 452 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Acute Cerebrovascular Disease Clear all
Completed No phase listed Observational

Mapping the Natural History of Parenychymal and Cerebral Perfusion Changes in Acute Ischemic and Hemorrhagic Strokes

NCT05865795
View directory record Official record
Conditions
Acute Ischemic Stroke, Hemorrhagic Stroke
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Jul 24, 2026, 1:55 AM EDT
Completed No phase listed Observational

IMPROVE Stroke Care- Developing and Optimizing Regional Systems of Stroke Care

NCT04242784
View directory record Official record
Conditions
Acute Stroke, Intracranial Hemorrhages, Subarachnoid Hemorrhage
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
21,646 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
9
States / cities
Asheville, North Carolina • Charlotte, North Carolina • Concord, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

Metacognitive-Strategy Training in Sub-Acute Stroke

NCT04099511
View directory record Official record
Conditions
Stroke
Interventions
Usual Care Occupational Therapy-Outpatient, Cognitive Orientation to daily Occupational Performance
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
50 Years to 85 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Somatic Dysfunction in Patients With Acute Cerebrovascular Disease

NCT06605014
View directory record Official record
Conditions
Stroke, Acute, TIA, Reproducibility of Results, Osteopathic Manipulation, Health-Related Quality-of-Life
Interventions
Not listed
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Jul 24, 2026, 1:55 AM EDT
Active, not recruiting Phase 4 Interventional

EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction

NCT05284747
View directory record Official record
Conditions
Cardiovascular Disease, Myocardial Infarction, Stroke, Coronary Revascularization
Interventions
Evolocumab, Routine Lipid Management
Drug
Lead sponsor
Amgen
Industry
Eligibility
18 Years to 99 Years
Enrollment
6,019 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
81
States / cities
Birmingham, Alabama • Fairhope, Alabama • Huntsville, Alabama + 73 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2025 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 1 Interventional Results available

Safety Study of External Counterpulsation as a Treatment for Acute Ischemic Stroke

NCT00983749
View directory record Official record
Conditions
Stroke
Interventions
Full-pressure ECP, Sham-pressure ECP
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
3
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2016 · Synced Jul 24, 2026, 1:55 AM EDT
Terminated Not applicable Interventional

Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window (ImpACT-24A)

NCT03767192
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Active Stimulation, Sham Stimulation
Device
Lead sponsor
BrainsGate
Industry
Eligibility
18 Years to 85 Years
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 27, 2019 · Synced Jul 24, 2026, 1:55 AM EDT
Suspended Not applicable Interventional

Post-Stroke Enhancement of Delirium Outcomes With Reduction in Neuro-checks

NCT06038136
View directory record Official record
Conditions
Stroke, Acute, Stroke, Ischemic, Delirium, Neuro: Cerebrovascular Accident
Interventions
Decreased Neuro Checks overnight
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
538 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional

Study Impact of Nutritional Supplementary Treatment of Undernourished Stroke Patient on Functional Outcome Measures

NCT00332800
View directory record Official record
Conditions
Stroke
Interventions
Nutritional Supplementation
Drug
Lead sponsor
Burke Rehabilitation Hospital
Other
Eligibility
18 Years to 95 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jun 1, 2006 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 2 Interventional Results available

Blood Pressure After Endovascular Stroke Therapy-II

NCT04116112
View directory record Official record
Conditions
Acute Stroke, Endovascular Thrombectomy
Interventions
Nicardipine, Labetalol, Hydralazine
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Hartford, Connecticut • Cincinnati, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Jul 24, 2026, 1:55 AM EDT
Withdrawn Phase 1 Interventional

PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia

NCT05295784
View directory record Official record
Conditions
Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Caffeine
Interventions
Caffeine citrate
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
0 Hours to 24 Hours
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
2
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 1 Interventional

Superselective Administration of VErapamil During Recanalization in Acute Ischemic Stroke

NCT02235558
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Verapamil
Drug
Lead sponsor
Justin Fraser
Other
Eligibility
21 Years to 85 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 22, 2017 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

VNS-supplemented Motor Retraining After Stroke

NCT04088578
View directory record Official record
Conditions
Stroke, Acute
Interventions
Training, Vagus Nerve Stimulation, Sham Stimulation
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

Solitaire™ With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial

NCT01657461
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Solitaire revascularization device
Drug · Device
Lead sponsor
Medtronic Neurovascular Clinical Affairs
Industry
Eligibility
18 Years to 80 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional

Feasibility of Video Gaming Technology for Arm Recovery Early Post-stroke

NCT06691880
View directory record Official record
Conditions
Subacute Stroke, Acute Stroke
Interventions
MindPod Dolphin VGT, Bimanual Arm Trainer VGT
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 90 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional

Acute Probiotic Supplementation and Endothelial Function

NCT04364074
View directory record Official record
Conditions
Coronary Artery Disease, Hypertension, Hyperlipidemias, Peripheral Vascular Diseases, Cerebral Arterial Diseases
Interventions
Goodbelly, Placebo
Dietary Supplement
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
21 Years to 89 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional Results available

Michigan Stroke Transitions Trial

NCT02653170
View directory record Official record
Conditions
Acute Stroke
Interventions
SCM, SCM and VSSP
Other
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Ann Arbor, Michigan • Lansing, Michigan • Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional

tDCS and Physical Therapy in Stroke

NCT00542256
View directory record Official record
Conditions
Cerebrovascular Accident
Interventions
Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy, Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Not applicable Interventional

REperfusion With Cooling in CerebraL Acute IscheMia II

NCT03804060
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Thermogard XP3, Recanalization only
Device · Procedure
Lead sponsor
ZOLL Circulation, Inc., USA
Industry
Eligibility
18 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
8
States / cities
Marietta, Georgia • Honolulu, Hawaii • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Jul 24, 2026, 1:55 AM EDT
Completed No phase listed Observational

Flow Arrest Safety and Technical Success With Balloon Guide Catheters

NCT04416659
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Neuro-vascular access
Device
Lead sponsor
Medtronic Neurovascular Clinical Affairs
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
9
States / cities
Phoenix, Arizona • Englewood, Colorado • Jacksonville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Jul 24, 2026, 1:55 AM EDT
Recruiting Not applicable Interventional

Variable Intensive Early Walking Post-Stroke - 2 (VIEWS-2)

NCT05727930
View directory record Official record
Conditions
Stroke
Interventions
High-intensity, task-specific (i.e., walking) interventions, High-intensity, non-specific physical therapy interventions, Low-intensity, task-specific physical therapy interventions, Low-intensity, non-specific physical therapy interventions
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jul 24, 2026, 1:55 AM EDT
Terminated Phase 2 Interventional Results available

Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)

NCT00252239
View directory record Official record
Conditions
Stroke
Interventions
tenecteplase, tissue plasminogen activator, tPA
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
9
States / cities
San Diego, California • Englewood, Colorado • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Jul 24, 2026, 1:55 AM EDT
Withdrawn Phase 2 Interventional

REGENESIS (US): A Phase IIb Prospective, Randomized, Double-blind, Placebo Controlled Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients

NCT00715364
View directory record Official record
Conditions
Stroke
Interventions
NTx™-265: rhCG, then rEPO, Saline Placebo
Drug
Lead sponsor
Stem Cell Therapeutics Corp.
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Newport Beach, California • Orange, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2011 · Synced Jul 24, 2026, 1:55 AM EDT
Completed Phase 2 Interventional Results available

Beta-hCG + Erythropoietin in Acute Stroke

NCT00362414
View directory record Official record
Conditions
Acute Stroke
Interventions
Dual Growth Factor
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
21 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2016 · Synced Jul 24, 2026, 1:55 AM EDT