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Showing 1–24 of 122 matching trials from the live ClinicalTrials.gov search.
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Active, not recruiting Not applicable Interventional

Posterior vs. Anterior Tympanostomy Tube Placement

NCT06191562
Conditions
Otitis Media in Children, Chronic Otitis Media With Effusion, Recurrent Acute Otitis Media
Interventions
Tympanostomy tube
Device
Lead sponsor
David Chi, MD
Other
Eligibility
6 Months to 14 Years
Enrollment
386 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Sewickley, Pennsylvania
Recruiting Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy of wSp Vaccine in Young Children

NCT07216430
Conditions
Acute Otitis Media (AOM)
Interventions
wSp vaccine, Saline (0.9% NaCl)
Biological
Lead sponsor
Serum Life Science Europe GmbH
Industry
Eligibility
5 Months to 7 Months
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
7
States / cities
Pittsford, New York • Rochester, New York
Conditions
Acute Otitis Media
Interventions
Acute Otitis Media Choice Decision Aid, Usual Care
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
6 Months to 18 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Conditions
PREVENTION OF INVASIVE PNEUMOCOCCAL DISEASE, Prevention of Pneumococcal-induced Acute Otitis Media
Interventions
Inactivated whole-cell Streptococcus pneumoniae vaccine, Placebo
Biological · Drug
Lead sponsor
Serum Life Science Europe GmbH
Industry
Eligibility
18 Years to 49 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Rochester, New York
Conditions
Otitis Media, Suppurative, Otitis Media, Purulent
Interventions
Telithromycin, Azithromycin
Drug
Lead sponsor
Sanofi
Industry
Eligibility
6 Months to 6 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Completed Not applicable Interventional Accepts healthy volunteers

Echinacea Purpurea and Osteopathy in Children With Recurrent Otitis Media

NCT00689468
Conditions
Otitis Media
Interventions
Cranial osteopathic manipulative treatment., Echinacea purpurea, Sham osteopathic manipulative treatment, "Echinacea purpurea" placebo
Procedure · Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
12 Months to 60 Months
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2002
U.S. locations
3
States / cities
Tucson, Arizona
Conditions
Otorrhea, Otitis Media With Effusion in Children
Interventions
Otiprio, Ciprodex
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
6 Months to 10 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Phase 2Phase 3 Interventional Results available

Evaluation of the Tympanostomy Tube Delivery System

NCT01202578
Conditions
Otitis Media With Effusion, Acute Otitis Media
Interventions
tympanostomy tube
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
6 Months and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
4
States / cities
Port Saint Lucie, Florida • Louisville, Kentucky • San Antonio, Texas + 1 more
Completed Phase 2 Interventional Results available

Open-Label Study of OTO-201 for Treatment of AOMT

NCT02408796
Conditions
Acute Otitis Media, AOMT
Interventions
OTO-201
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
5
States / cities
Fresno, California • Fort Lauderdale, Florida • Charlotte, North Carolina + 2 more
Conditions
Otitis Media
Interventions
Tube Delivery System (TDS)
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
6 Months to 21 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Port Saint Lucie, Florida
Conditions
Acute Otitis Media
Interventions
Drug: OP0201 20mg, Drug: Placebo 0mg
Combination Product
Lead sponsor
Novus Therapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
2
States / cities
Bellflower, California • Miami, Florida
Conditions
Otitis Media
Interventions
3-Part Intervention, 4-Part Intervention, 1-part intervention
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Months to 18 Years
Enrollment
55,779 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute, Septic Arthritis, Orbital Cellulitis, Facial Cellulitis, Mastoiditis, Cervical Adenitis, Retropharyngeal Abscess, Peritonsillar Abscess
Interventions
Trimethoprim Sulfamethoxazole
Drug
Lead sponsor
Indiana University
Other
Eligibility
2 Months to 18 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Completed No phase listed Observational Accepts healthy volunteers

Eustachian Tube Growth and Development

NCT00422929
Conditions
Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 3 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Acute Otitis Media
Interventions
cefdinir (Omnicef), azithromycin
Drug
Lead sponsor
Abbott
Industry
Eligibility
6 Months to 6 Years
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
30
States / cities
Columbiana, Alabama • Montgomery, Alabama • Ozark, Alabama + 24 more
Conditions
Acute Otitis Media
Interventions
Xylitol syrup, Placebo
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
6 Months to 5 Years
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Boston, Massachusetts
Conditions
Ear Infection, Otitis Media
Interventions
Solo+ Tympanostomy Tube Device
Device
Lead sponsor
AventaMed DAC
Industry
Eligibility
6 Months to 15 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Milwaukee, Wisconsin
Completed No phase listed Observational Accepts healthy volunteers

Clinical Development of Deep Learning for the OtoSight

NCT04722770
Conditions
Otitis Media Acute
Interventions
PhotoniCare OtoSight Middle Ear Scope
Device
Lead sponsor
PhotoniCare, Inc.
Industry
Eligibility
6 Months to 4 Years
Enrollment
188 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers

Broad Implementation of Outpatient Stewardship

NCT05127161
Conditions
Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
Interventions
Broad Implementation of Outpatient Stewardship (BIOS) intervention
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Months to 12 Years
Enrollment
1,032 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
5
States / cities
Plantation, Florida • Cleveland, Ohio • Hershey, Pennsylvania + 1 more
Completed No phase listed Observational Accepts healthy volunteers Results available

Wide Frequency Band Test of Hearing in Veterans

NCT02019888
Conditions
Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis, Tympanic Membrane Perforation, Otitis Media With Effusion, Cholesteatoma
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 89 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
2
States / cities
Portland, Oregon • Mountain Home, Tennessee
Completed No phase listed Observational Results available

Evaluation of Moderate to Severe Influenza Outcomes in Children

NCT02979626
Conditions
Influenza, Otitis Media, Lower Resp Tract Infection, Encephalitic Infection, Myositis Viral, Fever
Interventions
Respiratory nasal swab
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
6 Months to 8 Years
Enrollment
1,478 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Aurora, Colorado • Broomfield, Colorado
Conditions
Community-acquired Pneumonia, Acute Otitis Media, Pharyngitis
Interventions
Quasi experimental intervention
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
26,139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Completed Phase 2 Interventional Results available

Effect of Simethicone on Eustachian Tube Dysfunction

NCT01312038
Conditions
Otitis Media
Interventions
Simethicone, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Cleft Palate, Tube Disorders Eustachian, Velopharyngeal Incompetence Due to Cleft Palate, Velopharyngeal Insufficiency
Interventions
EMST150
Device
Lead sponsor
Noel Jabbour
Other
Eligibility
6 Years to 17 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania