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Showing 1–24 of 119 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Acute Otitis Media (AOM) Clear all
Completed Phase 3 Interventional Results available

OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement

NCT01949155
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
OTO-201, Sham
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2016 · Synced Jun 28, 2026, 5:01 AM EDT
Active, not recruiting Not applicable Interventional

In-Office Clinical Study of the Solo+ TTD

NCT05741333
View directory record Official record
Conditions
Ear Infection, Otitis Media
Interventions
Solo+ Tympanostomy Tube Device (Solo+ TTD)
Device
Lead sponsor
AventaMed DAC
Industry
Eligibility
6 Months to 13 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
7
States / cities
Alexander City, Alabama • Huntsville, Alabama • Opelika, Alabama + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

A Trial of Point of Care Information in Ambulatory Pediatrics

NCT00368823
View directory record Official record
Conditions
Acute Otitis Media, Allergic Rhinitis, Sinusitis, Constipation, Pharyngitis, Croup, Urticaria, Bronchiolitis
Interventions
Electronic point-of-care delivery system
Device
Lead sponsor
University of Washington
Other
Eligibility
0 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2003
U.S. locations
2
States / cities
Seattle, Washington • Skagit Valley, Washington
Source: ClinicalTrials.gov public record
Updated Aug 28, 2006 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Phase 1 Interventional Results available

Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis Media

NCT03766373
View directory record Official record
Conditions
Acute Otitis Media
Interventions
Drug: OP0201 20mg, Drug: Placebo 0mg
Combination Product
Lead sponsor
Novus Therapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
2
States / cities
Bellflower, California • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Jun 28, 2026, 5:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Development of Deep Learning for the OtoSight

NCT04722770
View directory record Official record
Conditions
Otitis Media Acute
Interventions
PhotoniCare OtoSight Middle Ear Scope
Device
Lead sponsor
PhotoniCare, Inc.
Industry
Eligibility
6 Months to 4 Years
Enrollment
188 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2024 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety Study of a Single Dose of Pneumococcal Whole-Cell Vaccine in Healthy Adults

NCT07059182
View directory record Official record
Conditions
PREVENTION OF INVASIVE PNEUMOCOCCAL DISEASE, Prevention of Pneumococcal-induced Acute Otitis Media
Interventions
Inactivated whole-cell Streptococcus pneumoniae vaccine, Placebo
Biological · Drug
Lead sponsor
Serum Life Science Europe GmbH
Industry
Eligibility
18 Years to 49 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Not applicable Interventional Results available

Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions

NCT06027593
View directory record Official record
Conditions
Community-acquired Pneumonia, Acute Otitis Media, Pharyngitis
Interventions
Quasi experimental intervention
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
26,139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jun 28, 2026, 5:01 AM EDT
Active, not recruiting Not applicable Interventional

RELAX: Reducing Length of Antibiotics for Children With Ear Infections

NCT05608993
View directory record Official record
Conditions
Acute Otitis Media, Pediatric Infectious Disease, Ear Infection
Interventions
High Intensity Intervention, Low Intensity Intervention
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
2 Years to 17 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement

NCT01188551
View directory record Official record
Conditions
Chronic Otitis Media
Interventions
Dexmedetomidine, Fentanyl, Midazolam
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 31, 2014 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Not applicable Interventional Results available

Osteopathic Otitis Media Research Study

NCT00520039
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
osteopathic manipulative medicine (OMM)
Procedure
Lead sponsor
West Virginia School of Osteopathic Medicine
Other
Eligibility
6 Months to 2 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Biddeford, Maine • Lewisburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2018 · Synced Jun 28, 2026, 5:01 AM EDT
Terminated Phase 3 Interventional

Adenoidectomy for Otitis Media in 2-3 Year Old Children

NCT00016497
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
bilateral myringotomy, bilateral myringotomy and tubes, adenoidectomy
Procedure
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
24 Months to 47 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 23, 2006 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Not applicable Interventional Results available

Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media

NCT02567825
View directory record Official record
Conditions
Acute Otitis Media
Interventions
Tympanostomy tube placement, Amoxicillin-Clavulanate and/or Ceftriaxone, Ofloxacin Otic
Device · Drug
Lead sponsor
Alejandro Hoberman
Other
Eligibility
6 Months to 35 Months
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 14, 2022 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Not applicable Interventional Results available

Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose

NCT01855425
View directory record Official record
Conditions
CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media, Otospongiosis, Otosclerosis, Pulsatile Tinnitus, Cholesteatoma
Interventions
Radiation
Radiation
Lead sponsor
Carestream Health, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Jun 28, 2026, 5:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Earset Healthy Volunteer Study

NCT01611246
View directory record Official record
Conditions
Otitis Media
Interventions
Iontophoresis System With Earset
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
12 Months and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
East Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Jun 28, 2026, 5:01 AM EDT
Terminated Phase 2 Interventional Results available

Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance

NCT01511107
View directory record Official record
Conditions
Acute Otitis Media
Interventions
Amoxicillin-Clavulanate, 10 days, Amoxicillin-Clavulanate, 5 days
Drug
Lead sponsor
Alejandro Hoberman
Other
Eligibility
6 Months to 23 Months
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Bardstown, Kentucky • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Jun 28, 2026, 5:01 AM EDT
Completed No phase listed Observational

Clinical Evaluation of the OtoSight

NCT03890107
View directory record Official record
Conditions
Otitis Media
Interventions
OtoSight Middle Ear Scope
Device
Lead sponsor
PhotoniCare, Inc.
Industry
Eligibility
Up to 17 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Jun 28, 2026, 5:01 AM EDT
Completed No phase listed Observational

Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults

NCT01251432
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Chronic Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Phase 1 Interventional Results available

Pediatric Pharmacokinetic (PK) Study of EXE844 Otic Suspension in Otitis Media at the Time of Tympanostomy Tube Insertion (OMTT)

NCT02539654
View directory record Official record
Conditions
Otitis Media With Effusion in Children, Otitis Media Recurrent
Interventions
EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion
Drug · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
6 Months to 12 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2018 · Synced Jun 28, 2026, 5:01 AM EDT
Completed Not applicable Interventional

Wait and See Antibiotic Prescription for Acute Otitis Media: A Randomized Controlled Trial

NCT00250900
View directory record Official record
Conditions
Otitis Media
Interventions
Prescription Fill Status
Behavioral
Lead sponsor
Yale University
Other
Eligibility
6 Months to 12 Years
Enrollment
240 participants
Timeline
2004 – 2005
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 29, 2006 · Synced Jun 28, 2026, 5:01 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy of wSp Vaccine in Young Children

NCT07216430
View directory record Official record
Conditions
Acute Otitis Media (AOM)
Interventions
wSp vaccine, Saline (0.9% NaCl)
Biological
Lead sponsor
Serum Life Science Europe GmbH
Industry
Eligibility
5 Months to 7 Months
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
7
States / cities
Pittsford, New York • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jun 28, 2026, 5:01 AM EDT
Not yet recruiting Not applicable Interventional

Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis Media

NCT07639775
View directory record Official record
Conditions
Otitis Media, Otitis Media Effusion, Otitis Media Recurrent, Otitis Media With Effusion in Children, Otitis Media Chronic, Otitis Media in Children, Tympanostomy Tube Insertion, Osteopathic Manipulative Treatment (OMT)
Interventions
Experimental Osteopathic Manipulative Treatment (OMT) Protocol, Control Osteopathic Manipulative Treatment (OMT) Protocol
Other
Lead sponsor
Sarah Vidal
Other
Eligibility
6 Months to 6 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Lynchburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jun 28, 2026, 5:01 AM EDT
Completed No phase listed Observational

ParentLink: Better and Safer Emergency Care for Children

NCT00457600
View directory record Official record
Conditions
Otitis Media, Urinary Tract Infection, Asthma, Head Injury
Interventions
patient-driven health IT product
Procedure
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 12 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
2
States / cities
Boston, Massachusetts • Weymouth, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 5, 2007 · Synced Jun 28, 2026, 5:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma

NCT07500532
View directory record Official record
Conditions
Acute Otitis Media (AOM), Strep Pharyngitis, Asthma Exacerbation, Pediatric Asthma
Interventions
Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group, Routine ENT Management (in-person and telehealth visits)- Control Group
Device · Other
Lead sponsor
Medentum Innovations
Industry
Eligibility
3 Years to 17 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tuscon, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jun 28, 2026, 5:01 AM EDT
Completed No phase listed Observational Results available

Study of the Hummingbird TTS™ Tympanostomy Tube System

NCT03503591
View directory record Official record
Conditions
Otitis Media
Interventions
Hummingbird Tympanostomy Tube System
Device
Lead sponsor
Preceptis Medical, Inc.
Industry
Eligibility
6 Months to 5 Years
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
4
States / cities
Minneapolis, Minnesota • Rochester, Minnesota • Saint Cloud, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Jun 28, 2026, 5:01 AM EDT