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Showing 1–24 of 176 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Acute Pain, Postoperative Clear all
Active, not recruiting Phase 3 Interventional Accepts healthy volunteers Results available

Opioid Analgesic Reduction Study

NCT04452344
View directory record Official record
Conditions
Opioid Use
Interventions
opioid-containing analgesic, two over-the-counter analgesics
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
1,815 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
5
States / cities
Chicago, Illinois • Baltimore, Maryland • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

Remote Ischemic PreConditioning Effect on Postsurgical Pain

NCT01383317
View directory record Official record
Conditions
Pain
Interventions
Thigh Tourniquet (VBM Single Use Tourniquet Cuff Items 20-34-722SLZ-1), Sham RIPC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
30 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

NCT05754190
View directory record Official record
Conditions
Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary, Fibromyalgia, Secondary, Fibromyalgia, Irritable Bowel Syndrome, Chronic Headache Disorder, Chronic Migraine, Chronic Pelvic Pain Syndrome, Temporomandibular Joint Disorders, Endometriosis-related Pain, Arthritis, Chronic Low-back Pain, Failed Back Surgery Syndrome, Post Herpetic Neuralgia, Neuropathic Pain, Painful Diabetic Neuropathy, Painful Bladder Syndrome, Trauma-related Wound, Trauma, Multiple, Chronic Pain Syndrome, Chronic Shoulder Pain
Interventions
SOMA pain manager smartphone application
Device
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Latinx Children and Surgery

NCT06020677
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute
Interventions
L-WebTIPS
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
2 Years to 7 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Terminated Phase 2 Interventional Results available

Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old

NCT02221674
View directory record Official record
Conditions
Moderate to Severe Acute Postoperative Pain
Interventions
Tapentadol
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
1 Day to 23 Months
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
4
States / cities
Palo Alto, California • Louisville, Kentucky • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2018 · Synced Jul 21, 2026, 4:04 PM EDT
Terminated Not applicable Interventional

Optimal Management of Pain in Hospitalized Patients - Opioid Tolerant Populations.

NCT02470728
View directory record Official record
Conditions
Pain, Acute Pain, Postoperative Pain
Interventions
New Clinical Pathway
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Orange, California • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Scheduled or As Needed Pain Regimen?

NCT06495632
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Motrin and narcotic
Drug
Lead sponsor
Cape Fear Valley Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Fayetteville, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 2 Interventional Results available

Intravenous Tapentadol in Post-Bunionectomy Pain

NCT01435577
View directory record Official record
Conditions
Bunion, Pain
Interventions
Tapentadol, Matching Placebo
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years to 65 Years
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 27, 2019 · Synced Jul 21, 2026, 4:04 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator

NCT06434714
View directory record Official record
Conditions
Post-operative Pain, Acute, Cesarean Section, Opioid Use Disorder, Opioids; Harmful Use
Interventions
Auricular percutaneous nerve field stimulator, Sham auricular percutaneous nerve field stimulator
Device
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years to 55 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

NCT06042608
View directory record Official record
Conditions
Postoperative Pain, Acute, Shoulder Pain
Interventions
intercostobrachial nerve block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting Phase 4 Interventional

Meloxicam in Mohs Micrographic Surgery

NCT07200544
View directory record Official record
Conditions
Postoperative Pain, Acute, Skin Cancer
Interventions
Meloxicam 7.5 mg, Meloxicam 15 mg, Acetaminophen 500mg
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 110 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting Early Phase 1 Interventional

A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction

NCT06864884
View directory record Official record
Conditions
Acute Post Operative Pain, Third Molar Extraction Surgery
Interventions
ARC-001, Placebo gel
Drug
Lead sponsor
Arcato Laboratories, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery

NCT00877799
View directory record Official record
Conditions
Acute Pain
Interventions
CR845, Placebo
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
21 Years to 60 Years · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
12
States / cities
Mobile, Alabama • Sheffield, Alabama • Phoenix, Arizona + 7 more
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

NCT01591382
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ketamine, Placebo, Hydromorphone PCA
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Jul 21, 2026, 4:04 PM EDT
Withdrawn Not applicable Interventional

The Effect of Light Therapy on Post-Surgical Pain

NCT05853731
View directory record Official record
Conditions
Intensive Care Unit, Cardiac Surgery
Interventions
Green light emitting diode, White light emitting diode
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jul 21, 2026, 4:04 PM EDT
Terminated Phase 4 Interventional Results available

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

NCT02746263
View directory record Official record
Conditions
Acute Pain, Postoperative
Interventions
IV acetaminophen, Oral acetaminophen, Morphine
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
50 Years to 90 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
2
States / cities
Pensacola, Florida • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Jul 21, 2026, 4:04 PM EDT
Terminated Not applicable Interventional Results available

Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement

NCT02161484
View directory record Official record
Conditions
Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty, Peripheral Nerve Block, Lumbar Plexus Nerve Block, Parasacaral (Sciatic) Nerve Block
Interventions
Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%, Bupivacaine 0.0625%
Procedure · Drug
Lead sponsor
Rita Merman
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2018 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Pain and Narcotic Usage After Orthopaedic Surgery

NCT03991546
View directory record Official record
Conditions
Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute, Analgesia, Opioid Use, Acceptance and Commitment Therapy, Orthopedics, Analgesics, Opioid, Text Messaging
Interventions
Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot
Behavioral
Lead sponsor
Christopher Anthony
Other
Eligibility
18 Years to 100 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 3 Interventional

A Randomized, Double-Blind Study of the Efficacy and Safety of Valdecoxib Compared to Placebo for Treatment of Post- Cholecystectomy Surgery Pain

NCT00661635
View directory record Official record
Conditions
Laparoscopic Cholecystectomy, Pain
Interventions
placebo, valdecoxib
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
65
States / cities
Birmingham, Alabama • Daphne, Alabama • Fairhope, Alabama + 47 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2008 · Synced Jul 21, 2026, 4:04 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Medrol Dosepak for Outpatient Total Knee Arthroplasty

NCT05097976
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methylprednisolone, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Oak Brook, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 3 Interventional Results available

An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain

NCT00726388
View directory record Official record
Conditions
Pain, Postoperative
Interventions
DIC075V (intravenous diclofenac sodium)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,050 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
46
States / cities
Birmingham, Alabama • Florence, Alabama • Mobile, Alabama + 37 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 2 Interventional

An Efficacy and Safety Study of LTG-001 Following Abdominoplasty

NCT07102459
View directory record Official record
Conditions
Acute Pain, Postoperative Pain Control
Interventions
Experimental: LTG-001 High Dose, Experimental: LTG-001 Low Dose, Active Comparator: HB/APAP, Placebo Comparator
Drug
Lead sponsor
Latigo Biotherapeutics
Industry
Eligibility
18 Years to 65 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Phoenix, Arizona • Atlanta, Georgia • Houston, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 4:04 PM EDT
Terminated Not applicable Interventional Results available

Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain

NCT01997567
View directory record Official record
Conditions
Internal Derangement of Hip, Acetabular Labrum Tear
Interventions
Ropivacaine, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Oak Park, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Jul 21, 2026, 4:04 PM EDT
Completed Phase 3 Interventional Results available

Co-crystal E-58425 vs Tramadol and Celecoxib for Moderate to Severe Acute Pain After Bunionectomy. Phase III Clinical Trial.

NCT03108482
View directory record Official record
Conditions
Acute Post-surgical Pain
Interventions
Co-crystal E-58425 (Tramadol/Celecoxib), Tramadol (Ultram®), Celecoxib (Celebrex®), Placebo
Drug
Lead sponsor
Esteve Pharmaceuticals, S.A.
Industry
Eligibility
18 Years and older
Enrollment
637 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Phoenix, Arizona • Anaheim, California • Pasadena, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Jul 21, 2026, 4:04 PM EDT