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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Conditions
PTSD, Acute Stress Disorder, Trauma-related Stressor
Interventions
Placebo, Hydrocortisone
Drug
Lead sponsor
Rachel Yehuda
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
New York, New York
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder
Interventions
Atorvastatin, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
2
States / cities
Houston, Texas
Recruiting Not applicable Interventional Accepts healthy volunteers

The Efficacy of Vitamin D Supplementation to Sustain Performance Outcomes

NCT07654777
Conditions
Acute Stress Reaction
Interventions
Vitamin D3 (Cholecalciferol), Oral Placebo Tablet
Dietary Supplement
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 40 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Silver Spring, Maryland
Conditions
Acute Stress Reaction
Interventions
iCOVER, Physical Presence with Reassurance
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Belmont, Massachusetts • Worcester, Massachusetts • Detroit, Michigan + 2 more
Completed Not applicable Interventional Accepts healthy volunteers

Acute Plasma Abeta Responses to Stress

NCT05521919
Conditions
Stress Reaction, Stress Physiology
Interventions
Sympathetic Nervous System Activation, No-stress
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Agitated; State, Acute Reaction to Stress, Agitation,Psychomotor
Interventions
Music
Other
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Syracuse, New York
Recruiting Not applicable Interventional Accepts healthy volunteers

Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

NCT07069478
Conditions
CBD, Cannabidiol, Stress, Acute Stress Reaction
Interventions
Stress Intervention
Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 70 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Trauma Injury, Trauma, Critical Illness, Microbiome, Chronic Anemia, Acute Blood Loss Anemia
Interventions
Data and tissue collection
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Gainesville, Florida
Completed Phase 4 Interventional Accepts healthy volunteers

Evaluation of Stress Disorders

NCT00050804
Conditions
Acute Traumatic Stress Disorders, Post-Traumatic Stress Disorders
Interventions
sertraline
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Acute Stress Reaction, Acute Stress Disorder, Post-traumatic Stress Disorder
Interventions
BXCL501 (dexmedetomidine HCl), Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
3
States / cities
Jacksonville, Florida • St Louis, Missouri • Charlottesville, Virginia
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Treatments for Acute Stress Disorder In Firefighters

NCT00183508
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cognitive behavioral therapy, Psychoeducation
Behavioral
Lead sponsor
Boston University
Other
Eligibility
21 Years to 65 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Breathing on Cognitive Performance and Stress

NCT06986135
Conditions
Stress, Acute Stress Reaction, Breathing Techniques, Cognitive Performance
Interventions
Box Breathing, Prolonged Exhalation, Normal Breathing
Other
Lead sponsor
Texas State University
Other
Eligibility
18 Years to 39 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Marcos, Texas
Conditions
Stress Disorders, Traumatic, Acute
Interventions
Propranolol
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Acute Stress Disorder, Anxiety, Pain
Interventions
Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg)
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
2 Years to 6 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Little Rock, Arkansas
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Early Intervention to Prevent Development of PTSD in Burn Survivors and Their Caregivers

NCT07656545
Conditions
Posttraumatic Stress Disorder, Burns, Traumatic Injury, Acute Stress Disorder, Trauma and Stressor Related Disorders, Trauma and Stress Related Disorders, Stress Disorder, Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute, Relationship, Social
Interventions
Promotion of Emotional Disclosure for Burns (PoED-B), minimally Enhanced Usual Care control (mEUC)
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Essential Oil Inhalation and Acute Stress Response in Healthy Adults

NCT07473544
Conditions
Psychological Stress
Interventions
Essential Oil Inhalation, Placebo Aroma Stick
Other
Lead sponsor
dōTERRA International
Industry
Eligibility
18 Years to 45 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pleasant Grove, Utah
Completed Not applicable Interventional Accepts healthy volunteers

Racial Discrimination and Stress Response

NCT05820659
Conditions
Stress Reaction; Acute
Interventions
peer rejection task and impossible puzzle task
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
9 Years to 69 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bowling Green, Kentucky
Conditions
Fear of Spiders, Acute Stress Reaction
Interventions
Propranolol, Hydrocortisone, Placebo (oral), Placebo (IM)
Drug
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 40 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Silver Spring, Maryland
Conditions
Suicide, Attempted
Interventions
Post Admission Cognitive Therapy (PACT)
Behavioral
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
2
States / cities
Bethesda, Maryland
Conditions
Acute Stress Reaction, Cognitive Performance
Interventions
Sparrow Hawk (Active), Sparrow Hawk (Sham)
Device
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years to 41 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Not yet recruiting Phase 2 Interventional Accepts healthy volunteers

Acute Effects of Cannabis on Cognition and Affect

NCT07296874
Conditions
Cannabis Use
Interventions
THC 20mg, Placebo
Drug
Lead sponsor
Washington State University
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pullman, Washington
Conditions
Anxiety Disorder
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Anxiety Disorders, Trauma, Generalized Anxiety Disorder, Panic Disorder, Agoraphobia, Illness Anxiety Disorder, Social Anxiety Disorder, Posttraumatic Stress Disorder, Acute Stress Disorder, Adjustment Disorder With Anxious Mood
Interventions
Capnometry-Guided Respiratory Intervention, Psycho-Education
Device · Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Austin, Texas
Conditions
Ischemic Stroke, Hyperglycemia
Interventions
No intervention is planned.
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 100 Years
Enrollment
88 participants
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota