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Conditions: Low Back Pain, Chronic Pain
Interventions: Physical Therapy, Cognitive Behavioral Therapy, Mindfulness, Phase I Treatment, Phase II Switching; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 64 Years
Enrollment: 749 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 3
States / cities: Baltimore, Maryland • Salt Lake City, Utah

Conditions: Down Syndrome, Adaptive Behavior, Quality of Life
Interventions: The MapHabit System; Device
Lead sponsor: MapHabit, Inc.; Industry
Eligibility: 7 Years to 17 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Brain Metastases, Adult, Brain Tumor - Metastatic, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Extra-cranial Solid Tumors
Interventions: Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV; Radiation
Lead sponsor: Ayal A. Aizer, MD; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Use
Interventions: Single Session Family Intervention; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 12 Years to 14 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Suicide
Interventions: Stage 1 Treatment as usual (TAU), Stage 1 CAMS, Stage 2 CAMS, Stage 2 Dialectical Behavioral Therapy (DBT); Behavioral
Lead sponsor: University of Nevada, Reno; Other
Eligibility: 18 Years to 25 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Reno, Nevada

Conditions: People Who Use Motorized Wheelchairs for Mobility
Interventions: Adaptive Rowing; Behavioral
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Columbia, South Carolina • West Columbia, South Carolina

Conditions: Perception of Things Changing Color, Adaptive Behavior
Interventions: Mode Switching Training; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2032
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Major Depressive Disorder, Post Traumatic Stress Disorder
Interventions: Positive Processes and Transition to Health (PATH); Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 3
States / cities: Newark, Delaware • Cleveland, Ohio • Seattle, Washington

Conditions: Autism Spectrum Disorder (ASD), Central Auditory Processing Disorder, Nervous System Disorder, Neurological Disorder
Interventions: Audio fairy tales; Behavioral
Lead sponsor: Natalia Poluektova; Other
Eligibility: 3 Years to 70 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Suicidal Thoughts and Behaviors
Interventions: STAMM-S; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 14 Years to 35 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Inflammation, Aging, Depression, Anxiety
Interventions: Bikram Hot Yoga Intervention, Hot Yoga Washout; Other
Lead sponsor: University of Arizona; Other
Eligibility: 30 Years to 45 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Suicide, Suicide, Attempted, Suicidal Ideation, Self Harm
Interventions: MI- Safety Plan, Texts messages, Monitoring, Portal follow-up, Booster call; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 13 Years to 17 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 3
States / cities: Ann Arbor, Michigan • Detroit, Michigan • Cincinnati, Ohio

Conditions: Hypertension
Interventions: THRIVE Intervention, Active Comparator; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 79 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Suicidal, Suicide, Attempted, Suicidal Ideation
Interventions: Electronic Safety Plan (ESP), Text support; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Alcohol Drinking, Cannabis Use
Interventions: Condition 1: Craving daily+PBS daily, Condition 2: Craving daily+PBS trigger, Condition 3: Craving trigger+PBS daily, Condition 4: Craving trigger+PBS trigger, Condition 5: PBS daily+ PBS trigger, Condition 6: Craving daily+Craving trigger, Condition 7: Craving daily+Craving trigger+PBS daily+PBS trigger, Condition 8: No daily or trigger craving or PBS; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years to 30 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Inactivity, Physical, Sedentary Behavior
Interventions: COT-Based Intervention; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 25 Years to 80 Years
Enrollment: 386 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: San Diego, California

Conditions: Depressive Disorder, Depression, Depressive Disorder, Major, Depressive Episode, Major Depressive Disorder
Interventions: Synchronized Transcranial Magnetic Stimulation (sTMS), Sham Stimulation; Device
Lead sponsor: Wave Neuroscience; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 14
States / cities: La Jolla, California • Los Angeles, California • Stanford, California + 11 more

Conditions: Smoking Cessation, Harm Reduction
Interventions: Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Attention-Deficit Hyperactivity Disorder
Interventions: HLD200 (methylphenidate hydrochloride); Drug
Lead sponsor: Ironshore Pharmaceuticals and Development, Inc; Other
Eligibility: 6 Years to 17 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Tobacco Use Cessation
Interventions: Brief telephone advice plus tailored text messages, Mailed nicotine replacement therapy, Proactive telephone coaching; Behavioral · Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus, Distress, Emotional
Interventions: ReCharge, TakeCharge; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 30 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Obesity, Overweight, Overweight and Obesity
Interventions: Core Behavioral Weight Loss (BWL) Intervention, Behavior Change Technique 1 Message (Action Planning), Behavior Change Technique 2 Message (Discrepancy between Current Behavior and Goal), Behavior Change Technique 3 Message (Feedback on Outcome of Behavior), Behavior Change Technique 4 Message (Social Support), Behavior Change Technique 5 Message (Social Comparison), Behavior Change Technique 6 Message (Social Reward), Behavior Change Technique 7 Message (Focus on Past Success); Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 39 Years
Enrollment: 255 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Obsessive-Compulsive Disorder
Interventions: Activa PC+S DBS implant for OCD, One Month Blinded Discontinuation Period; Device · Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 21 Years to 70 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 3
States / cities: Pittsburgh, Pennsylvania • Providence, Rhode Island • Houston, Texas

Conditions: Fecal Incontinence
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: Female only
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 8
States / cities: Birmingham, Alabama • La Jolla, California • San Diego, California + 5 more

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Optimize Low Back Pain

Life Skills Improved in Children With Down Syndrome After Using Assistive Technology

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

Developing a Digital Intervention to Prevent Risky Health Behaviors

Developing Adaptive Interventions for Suicidal College Students Seeking Treatment - SMART

Using an Adaptive Rower for People Using Motorized Wheelchairs

Visual Mode Switching in Color Perception

Positive Processes and Transition to Health

Mental And Speech Developmental Delay Autism Spectrum-Type Behavioral Disorder

Standardized Adaptive Music Medicine for Suicidality

Adaptive Stress Response: The Hot Yoga Study

Adaptive Intervention for Adolescents Following Inpatient Psychiatric Care

AdapTive Personalized Dietitian coacHing, Messaging and pRoduce prescrIption to improVE Healthy Dietary Behaviors

Improving Coping to Reduce Suicide Risk Following ED Discharge

Mobile Intervention for Simultaneous Alcohol and Marijuana Use in Young Adults

The YourMove Study: Optimizing Individualized and Adaptive mHealth Interventions Via Control Systems Engineering Methods

Adaptive Design Study of NEST sTMS in Subjects With Major Depressive Disorder

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

Pharmacokinetics of HLD200 in Children and Adolescents With ADHD

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART

Just-in-time Adaptive Intervention Messaging in a Digital Weight Loss Intervention for Young Adults

Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)

Adaptive Behaviors Among Women With Bowel Incontinence: The ABBI Trial