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ClinicalTrials.gov public records Last synced Nov 5, 2026, 7:04 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 476 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Addiction, Opioid Clear all

Conditions: Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
Interventions: Gabapentin; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Chronic Pain, Opioid Dependence, Opioid Use
Interventions: Real iTBS, Sham iTBS, Real cTBS, Sham cTBS; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Charleston, South Carolina

Conditions: Opiate Dependence, Suicidal Ideation, Depression, Opioid Use, Opioid-Related Disorders, Opioid-use Disorder, Major Depressive Disorder
Interventions: Accelerated intermittent theta-burst stimulation (aiTBS); Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Opioid-Related Disorders, Substance-Related Disorders
Interventions: Buprenorphine; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 45 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 1998
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Opioid Dependence
Interventions: Aprepitant, Placebo pill; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 55 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
Interventions: Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder; Device · Behavioral
Lead sponsor: University of Alabama, Tuscaloosa; Other
Eligibility: 18 Years to 65 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Tuscaloosa, Alabama

Conditions: Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
Interventions: Sufentanil; Drug
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Opioid Dependence, Opioid Withdrawal, Opioid Detoxification
Interventions: Buprenorphine; Drug
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Opioid-use Disorder, Chronic Pain
Interventions: Active Comparator: Active tDCS + Active TUS, Sham Comparator: Sham tDCS + Sham TUS; Device
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 3
States / cities: Hinsdale, Illinois • Cambridge, Massachusetts • Cleveland, Ohio

Conditions: Heroin Dependence, Opioid-Related Disorders
Interventions: Hydromorphone; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Genetic Underpinning of Substance Abuse, Polymorphism-genetic, Drug Abuse/Dependence, Opiod-Related Disorders
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative, Opioid Use, Opioid Abuse, Opioid Dependence
Interventions: ReCOVER Enhanced Recovery Protocol; Procedure
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use Disorder
Interventions: Bias Modification Biofeedback; Device
Lead sponsor: Neurotype Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: PTSD, Depression, Opioid Use Disorder
Interventions: Modeling to Learn (MTL), Usual quality improvement (QI); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 720 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Opiate Dependence, Cocaine Dependence
Interventions: 11UCB-J PET Scan; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Chronic Pain, Opioid Addiction, Symptomatic Hypogonadism
Interventions: Testosterone replacement, Waitlist control; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder, Opioid Dependence
Interventions: Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training; Device · Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 60 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Opiate Dependence
Interventions: behavioral drug and HIV risk reduction counseling (BDRC), abstinence-contingent buprenorphine (ACB); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opiate Addiction, Pregnancy
Interventions: Magnitude Group, Frequency Group; Drug
Lead sponsor: Steve N. Caritis, MD; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Knoxville, Tennessee

Conditions: Opioid Use Disorder
Interventions: Computer-adaptive SAFE, Face-to-face SAFE, Usual Care; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Opioid Dependence, Opioid Withdrawal, Sleep Disturbance
Interventions: Placebo oral capsule, Low Dose Suvorexant, High Dose Suvorexant; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Dependence, Chronic Pain
Interventions: Enhanced Opioid Stewardship Program; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Opioid-use Disorder, Addiction, Depression, Post-traumatic Stress Disorder
Interventions: Collaborative Care; Behavioral
Lead sponsor: RAND; Other
Eligibility: 18 Years and older
Enrollment: 729 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 16
States / cities: Los Angeles, California • Santa Monica, California • Albuquerque, New Mexico + 5 more

Conditions: Opioid Abuse, Opioid Dependence, Opioid-Related Disorders, Opioid Use
Interventions: Lorcaserin, Placebo; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Richmond, Virginia

Search by objective public record fields.

Gabapentin Regimens and Their Effects on Opioid Consumption

Developing rTMS Treatment Strategies for Pain in Opiate Dependence

Accelerated Intermittent Theta-Burst Stimulation for Opiate Use Disorder

Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2

Aprepitant Effects in Intravenous Heroin Dependence

Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders

Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population

Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individuals

Optimization of NIBS for Treatment of Addiction

Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals

Impact of Delta Opioid Receptor Gene (OPRD1) Variations on Treatment Outcome in African Americans

A Multimodal Enhanced Recovery Program in Anorectal Surgery

Brain Training for Substance Use Disorders

Participatory System Dynamics vs Usual Quality Improvement: Staff Use of Simulation as an Effective, Scalable and Affordable Way to Improve Timely Mental Health Care?

Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

Testosterone Replacement for Male Opioid Agonist Maintained Patients

Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder

Drug Counseling and Abstinent-Contingent Take-Home Buprenorphine in Malaysia

Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy

Sex and Female Empowerment

Medical Management of Sleep Disturbance During Opioid Tapering

Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pain

Collaboration Leading to Addiction Treatment and Recovery From Other Stresses

Drug Interaction and Subjective Effects of Compounds for Opioid Use Disorder