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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adolescent - Emotional Problem Clear all
Terminated Not applicable Interventional

Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology

NCT05461599
View directory record Official record
Conditions
Depressive Symptoms, Major Depressive Disorder, Depression, Cardiology, Gastrointestinal Diseases, Depressive Disorder, Depressive Episode, Adolescent Behavior, Adolescent - Emotional Problem
Interventions
SparkRx Mobile App
Device
Lead sponsor
Limbix Health, Inc.
Industry
Eligibility
13 Years to 22 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Randomized, School-based Effectiveness Trial of the Adolescent Depression Awareness Program

NCT02099305
View directory record Official record
Conditions
Adolescent - Emotional Problem, Depression, Prevention Harmful Effects
Interventions
Adolescent Depression Awareness Program (ADAP)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 18 Years
Enrollment
17,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 11, 2017 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Shaping Actions and Responses to Emotions

NCT04719949
View directory record Official record
Conditions
Depression in Adolescence, Adverse Childhood Experiences
Interventions
Behavioral Activation (BA) Therapy, Problem Solving Therapy (PST)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 15 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness for at Risk Youth: Understanding Substance Use and Important Mechanisms of Change

NCT04160754
View directory record Official record
Conditions
Alcohol Use, Underage, Alcohol Problem Drinking, Substance Use
Interventions
Mindfulness Based Relapse Prevention, Control (CTL)
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 26 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Optimizing Residential Treatment Gains for Adolescents

NCT05764369
View directory record Official record
Conditions
Parenting, Adolescent - Emotional Problem, Mental Disorder in Adolescence
Interventions
Parenting Wisely Residential Treatment (PWRT), TAU
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
11 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Jul 21, 2026, 10:04 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Families and Middle School Success Project

NCT05400564
View directory record Official record
Conditions
Parenting, Parent-Child Relations, Self-regulation, Problem Behavior in School, School Adjustment, Depression
Interventions
Family Check-Up
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 21, 2026, 10:04 AM EDT
Recruiting No phase listed Observational

Children's Bipolar Network Treatment Trial I

NCT05427123
View directory record Official record
Conditions
Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder, Other Specified Bipolar and Related Disorder, Mood Instability, Child Mental Disorder, Adolescent - Emotional Problem
Interventions
Medication or psychosocial treatment
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
9 Years to 19 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Aurora, Colorado • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Light Therapy for Depression in Adolescent Outpatients

NCT05823090
View directory record Official record
Conditions
Depression, Adolescent - Emotional Problem
Interventions
light box (Carex DayLight Classic Model)
Device
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
12 Years to 18 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Unified Protocol for Adolescents (UP-A) Change Processes

NCT03102008
View directory record Official record
Conditions
Anxiety Disorders, Depression, Obsessive-Compulsive Disorder, Adolescent - Emotional Problem, Emotional Disorder
Interventions
Unified Protocol for Emotional Disorders in Adolescents (UP-A)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 17 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

NCT04478240
View directory record Official record
Conditions
Substance Use, Stress, Relation, Interpersonal, Bullying, Victimisation, Mental Health Issue, Sleep, Inadequate, Social Skills
Interventions
PeerLearning.net
Behavioral
Lead sponsor
Oregon Research Behavioral Intervention Strategies, Inc.
Industry
Eligibility
Not listed
Enrollment
924 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fuerte Program for Newcomer Immigrant Youth

NCT04156373
View directory record Official record
Conditions
Trauma, Psychological, Mental Disorder in Adolescence, Adolescent - Emotional Problem
Interventions
Fuerte
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years and older
Enrollment
321 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional

DBT-Based Parenting Intervention for Parents of Youth at Risk for Suicide

NCT04132284
View directory record Official record
Conditions
Adolescent - Emotional Problem, Suicide and Self-harm, Parenting
Interventions
DBT-Based Parenting Intervention, Treatment as Usual
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
13 Years to 18 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Biopsychosocial Outcomes of Mindfulness-based Instruction

NCT05787483
View directory record Official record
Conditions
Specific Learning Disability, Mental Health Issue
Interventions
MindUP group, active control group
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 14 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Jul 21, 2026, 10:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

TRIAD Project: Qualitative Study of Adolescent Depression and Smoking

NCT00592696
View directory record Official record
Conditions
Adolescent - Emotional Problem, Smoking
Interventions
Not listed
Lead sponsor
Drexel University College of Medicine
Other
Eligibility
12 Years to 19 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 30, 2014 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Loves Company: Combatting Emotional Disturbance in the Digital Age

NCT03443206
View directory record Official record
Conditions
Adolescent - Emotional Problem
Interventions
anonymous social support, psychoeducation, online resources
Other
Lead sponsor
Northwell Health
Other
Eligibility
14 Years to 17 Years
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Glen Oaks, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2022 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Phase 3 Interventional

Family Health and Development Project

NCT01567969
View directory record Official record
Conditions
Serious Emotional Disturbance
Interventions
Intensive In-home Child and Adolescent Psychiatric Service, Home-based Child Treatment Coordination
Behavioral
Lead sponsor
Yale University
Other
Eligibility
6 Years to 16 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Jul 21, 2026, 10:04 AM EDT
Terminated Not applicable Interventional

Digital Therapeutic for Adolescent Depressive Symptoms in Hematology, Oncology, and Weight Management

NCT05351866
View directory record Official record
Conditions
Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode, Adolescent Behavior, Adolescent - Emotional Problem, Hematologic Diseases, Oncology, Weight, Body
Interventions
CBT-based mobile intervention for depression, Mobile control with education about depression
Device
Lead sponsor
Limbix Health, Inc.
Industry
Eligibility
13 Years to 22 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2023 · Synced Jul 21, 2026, 10:04 AM EDT
Active, not recruiting Not applicable Interventional

Testing FIRST in Youth Outpatient Psychotherapy

NCT04725721
View directory record Official record
Conditions
Anxiety, Depression, Trauma, Behavior Problem
Interventions
FIRST, Usual Care
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
7 Years to 15 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Cambridge, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jul 21, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT of a Brief Video Intervention Targeting Peer Inclusion to Reduce Depression-related Stigma in Adolescents

NCT06360107
View directory record Official record
Conditions
Depression, Adolescent - Emotional Problem, Stigma, Social, Help-Seeking Behavior
Interventions
brief video
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
14 Years to 18 Years
Enrollment
645 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Jul 21, 2026, 10:04 AM EDT
Enrolling by invitation No phase listed Observational

Social Media Concerns Related to Emotional Experiences in Naturalistic Settings (SCREENS)

NCT07278752
View directory record Official record
Conditions
Depression in Adolescence, Suicidal Ideation, Social Media Addiction, Mental Health Issue
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
13 Years to 18 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 21, 2026, 10:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of ACT OUT! Social Issue Theater on Youth and Adolescents

NCT04097496
View directory record Official record
Conditions
Social Competence, Bullying
Interventions
Act Out! Intervention
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
Not listed
Enrollment
1,537 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 8, 2020 · Synced Jul 21, 2026, 10:04 AM EDT
Recruiting Not applicable Interventional

Parent Intervention for Psychiatrically-Hospitalized Youth

NCT04797455
View directory record Official record
Conditions
Adolescent - Emotional Problem, Suicide and Self-harm, Parenting
Interventions
DBT-Based Parenting Intervention, Treatment as usual
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
12 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 10:04 AM EDT