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Showing 1–24 of 458 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adolescent Depression Clear all
Completed Not applicable Interventional

Depression & Insulin Sensitivity in Adolescents

NCT03263351
View directory record Official record
Conditions
Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance, Depression, Adolescent Obesity
Interventions
Cognitive-behavioral therapy group, Health education group
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
12 Years to 17 Years · Female only
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Jul 23, 2026, 1:25 AM EDT
Not listed Not applicable Interventional

N-acetylcysteine in the Treatment of Depressive Symptoms in Bipolar Offspring

NCT02865629
View directory record Official record
Conditions
Depression
Interventions
N-acetyl cysteine
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
15 Years to 24 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 13, 2018 · Synced Jul 23, 2026, 1:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

NCT05437588
View directory record Official record
Conditions
Major Depressive Disorder, Suicidal Ideas, Suicide, Attempted, MDD, Depression, Depression, Teen, Depression and Suicide, Depression in Adolescence, Suicide
Interventions
Genetic testing
Genetic
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 24 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Phase 3 Interventional Results available

Open-label Ziprasidone Study for Psychosis Treatment in Adolescents

NCT00421954
View directory record Official record
Conditions
Schizophreniform Disorder, Schizoaffective Disorder, Psychosis, Depressive Disorder, Major, Bipolar Disorder
Interventions
Ziprasidone
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
13 Years to 17 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study

NCT04254796
View directory record Official record
Conditions
Healthy
Interventions
Training for Awareness, Resilience, and Action (TARA)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years to 18 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2023 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional

Social Media, Teen Moms and PPD

NCT01967394
View directory record Official record
Conditions
Postpartum Depression
Interventions
Use of internet based social marketing intervention, No use of social media
Other
Lead sponsor
University of Louisville
Other
Eligibility
13 Years to 21 Years · Female only
Enrollment
287 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
8
States / cities
Carrollton, Kentucky • Covington, Kentucky • Elizabethtown, Kentucky + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 28, 2015 · Synced Jul 23, 2026, 1:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program

NCT05789446
View directory record Official record
Conditions
Chronic Stress, Anxiety, Depression
Interventions
Building a Strong Identity and Coping Skills
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
11 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
5
States / cities
Harrisburg, Pennsylvania • Hershey, Pennsylvania • Spring Mills, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional

CBT Insomnia Teens: Augmenting SSRIs to Improve Youth Depression

NCT02290496
View directory record Official record
Conditions
Insomnia, Depression
Interventions
CBT for Insomnia (CBT-I), Sleep Hygiene (SH)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
12 Years to 19 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 16, 2018 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Teen Brain Training (TBT)

NCT06183580
View directory record Official record
Conditions
Suicide, Attempted, Suicide, Ideation, Depression
Interventions
neurofeedback training involving dACC, neurofeedback training involving amygdala
Other
Lead sponsor
University of Minnesota
Other
Eligibility
11 Years to 18 Years
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cradling Our Future Through Family Strengthening Study

NCT00373750
View directory record Official record
Conditions
Substance Abuse, Post-partum Depression, Depression
Interventions
Family Spirit Intervention
Procedure
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
12 Years to 19 Years · Female only
Enrollment
322 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
5
States / cities
Fort Defiance, Arizona • San Carlos, Arizona • Tuba City, Arizona + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Phase 4 Interventional

Substance Dependent Teens - Impact of Treating Depression Study 1 - 1

NCT00061113
View directory record Official record
Conditions
Alcohol-Related Disorders, Marijuana Abuse, Substance-Related Disorders
Interventions
Fluoxetine + outpatient cognitive behavioral therapy, fluoxetine, placebo + CBT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 19 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 23, 2026, 1:25 AM EDT
Terminated Not applicable Interventional

Lamotrigine in Treatment Resistant Depression in Adolescents

NCT00284791
View directory record Official record
Conditions
Adolescent Depression
Interventions
Lamotrigine (drug), Fluoxetine (drug), sertraline (drug)
Drug
Lead sponsor
MaineHealth
Other
Eligibility
13 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers

NCT00436150
View directory record Official record
Conditions
Depression
Interventions
Interpersonal therapy-based treatment, Standard care
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 11, 2013 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Stigma Towards Depression Among Adolescents

NCT04760223
View directory record Official record
Conditions
Stigma, Social
Interventions
Video intervention
Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
14 Years to 18 Years
Enrollment
1,183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
2
States / cities
New Haven, Connecticut • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility and Efficacy of a Digital Mental Health Intervention for Teen Wildfire Survivors

NCT03868761
View directory record Official record
Conditions
Disaster, PTSD, Adolescent Behavior, Trauma, Anxiety, Stress
Interventions
Sonoma Rises
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
13 Years to 17 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neural Components Underlying the Treatment of Adolescent Depression

NCT01717508
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
13 Years to 18 Years · Female only
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy for Adolescents and Young Adults With Neurofibromatosis and Chronic Pain

NCT01633008
View directory record Official record
Conditions
Neurofibromatosis
Interventions
ACT Workshop
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
12 Years to 99 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2019 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive Disorder

NCT02431806
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Placebo, Levomilnacipran, Fluoxetine
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
12 Years to 17 Years
Enrollment
552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
48
States / cities
Dothan, Alabama • Tucson, Arizona • Anaheim, California + 40 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Phase 2 Interventional Results available

Study Evaluating Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR) In The Treatment Of Child and Adolescent Outpatients With Major Depressive Disorder

NCT00669110
View directory record Official record
Conditions
Depressive Disorder, Major Depressive Disorder
Interventions
Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR)
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
7 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
9
States / cities
Little Rock, Arkansas • North Miami, Florida • Terre Haute, Indiana + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Jul 23, 2026, 1:25 AM EDT
Withdrawn Phase 3 Interventional

Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)

NCT01228890
View directory record Official record
Conditions
Depression, Anxiety, Externalizing Symptoms, Substance Abuse
Interventions
CATCH-IT, AMPE
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
13 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
4
States / cities
Chicago, Illinois • Evanston, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 16, 2012 · Synced Jul 23, 2026, 1:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural Mechanisms of Family-Focused Treatment for Youth Depression

NCT06289010
View directory record Official record
Conditions
Childhood Depression
Interventions
Family-Focused Treatment for Childhood-Depression (FFT-CD)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
7 Years to 12 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Phase 2 Interventional

Coping With Adolescent Peer Victimization and Reducing Anxious/Depressed Symptoms

NCT02011438
View directory record Official record
Conditions
Depression, Social Anxiety
Interventions
UTalk
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 18 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Dec 16, 2015 · Synced Jul 23, 2026, 1:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using a Mentoring Afterschool Program to Improve Adolescent Mental Health and Physical Activity: A Pilot Study

NCT06686784
View directory record Official record
Conditions
Depression
Interventions
After School Plus
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
9 Years to 99 Years
Enrollment
209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jul 23, 2026, 1:25 AM EDT
Not yet recruiting Not applicable Interventional

Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial

NCT07628192
View directory record Official record
Conditions
Suicidal Ideation, Suicide Attempt, Safety Plan, Depression / Major Depressive Disorder, Hopelessness
Interventions
CAMS Brief Intervention, Stanley-Brown Safety Planning Intervention
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
12 Years to 17 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 23, 2026, 1:25 AM EDT