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Showing 1–24 of 167 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adolescent Substance Abuse Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Adaptation Processes in School-Based Substance Abuse Programs

NCT01755533
View directory record Official record
Conditions
Substance Use
Interventions
Rural curriculum, Classic curriculum
Other
Lead sponsor
Penn State University
Other
Eligibility
11 Years to 15 Years
Enrollment
2,827 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Parenting Mindfully Study

NCT02038231
View directory record Official record
Conditions
Substance Abuse, Risk Behaviors
Interventions
Parenting Mindfully Program, Parent Education Program
Behavioral · Other
Lead sponsor
George Mason University
Other
Eligibility
12 Years to 16 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping

NCT07413432
View directory record Official record
Conditions
Cannabis, Vaping, Emotion Regulation
Interventions
Virtual reality videogame intervention for vaping prevention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Behavioral Intervention for Minority Adolescent Women

NCT01387646
View directory record Official record
Conditions
Sexually Transmitted Infection, Substance Use, Abuse, Pregnancy
Interventions
Project IMAGE
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
14 Years to 18 Years · Female only
Enrollment
562 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 3, 2011 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 1 Interventional

Family Check-Up for Adolescents and Siblings

NCT00925340
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Family Check Up, Psychoeducation
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 18 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 28, 2014 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Testing a Promising Treatment for Youth Substance Abuse in a Community Setting

NCT02130479
View directory record Official record
Conditions
Substance Abuse, Delinquency, Mental Health
Interventions
Contingency Management-Family Engagement, Treatment as Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 17 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Florence, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Sep 10, 2026, 6:35 AM EDT
Withdrawn Phase 4 Interventional

Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents

NCT01015066
View directory record Official record
Conditions
Opiate Addiction
Interventions
Buprenorphine/naloxone, Naltrexone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
16 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2014 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 3 Interventional

A Brief Marijuana Intervention for Adolescent Women - 1

NCT00227864
View directory record Official record
Conditions
Marijuana Abuse, Sexual Risk Behaviors
Interventions
Behavior Therapy, Treatment as Usual
Behavioral · Other
Lead sponsor
Butler Hospital
Other
Eligibility
15 Years to 24 Years · Female only
Enrollment
326 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 10, 2015 · Synced Sep 10, 2026, 6:35 AM EDT
Withdrawn Not applicable Interventional

Reducing Problematic Substance Use in Youth With Chronic Medical Conditions

NCT01709201
View directory record Official record
Conditions
Alcohol Abuse, Drug Abuse
Interventions
Brief Intervention
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Sep 10, 2026, 6:35 AM EDT
Recruiting Not applicable Interventional

Neuroimaging of Adolescent Cannabis Use Treatment

NCT07340554
View directory record Official record
Conditions
Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional

Teen Success Project

NCT03015805
View directory record Official record
Conditions
Substance Abuse
Interventions
Contingency Management, Probation as Usual
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
12 Years to 18 Years
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
14
States / cities
Burley, Idaho • Caldwell, Idaho • Gooding, Idaho + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Brief Intervention for Drug Abusing Adolescents

NCT00350909
View directory record Official record
Conditions
Drug Abuse
Interventions
brief intervention (cognitive-behavioral therapy)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 19 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 19, 2008 · Synced Sep 10, 2026, 6:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Wakaya: Rising Up for Choctaw Youth Health

NCT05818384
View directory record Official record
Conditions
Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
Interventions
Wakaya: Rising Up for Choctaw Youth Curriculum
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 19 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Durant, Oklahoma • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brief Interventions With Text Messaging to Reduce Adolescent Alcohol and Marijuana Use

NCT03401333
View directory record Official record
Conditions
Alcohol Drinking, Marijuana
Interventions
Text Messaging and Brief Negotiation Interview
Behavioral
Lead sponsor
Yale University
Other
Eligibility
13 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Skills and Motivation at the Rhode Island Training School (Project SMART) - 1

NCT00227890
View directory record Official record
Conditions
Alcoholic, Marijuana Misuse
Interventions
MI/CBT, RT/TU
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
14 Years to 19 Years
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
2
States / cities
Cranston, Rhode Island • Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 2, 2017 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 3 Interventional Results available

Brief Strategic Family Therapy for Adolescent Drug Abusers

NCT00095303
View directory record Official record
Conditions
Substance Abuse
Interventions
Brief Strategic Family Therapy (BSFT), Treatment as Usual
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 17 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
7
States / cities
Tucson, Arizona • Tarzana, California • Thornton, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2015 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adolescent Family-Based Alcohol Prevention

NCT00858065
View directory record Official record
Conditions
Alcohol Abuse, Drug Abuse
Interventions
Strengthening Families Program (SFP), Family Matters
Behavioral
Lead sponsor
Pacific Institute for Research and Evaluation
Other
Eligibility
11 Years to 12 Years
Enrollment
1,228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
2
States / cities
Berkeley, California • Oakland, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 10, 2026, 6:35 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Clinician Practice Companion to Address Youth Substance Use

NCT07725289
View directory record Official record
Conditions
Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use, Opioid Use Disorder, Drug Overdose, Overdose Prevention, Co-occurring Mental Health Conditions
Interventions
Practice Companion
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 2 Interventional

Targeting HIV Risk Behaviors in Juvenile Drug Court-Involved Youth

NCT01511380
View directory record Official record
Conditions
Substance Use, Sexual Risk Behaviors
Interventions
Risk Reduction Therapy for Adolescents, Usual services
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 17 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 3, 2016 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Phase 1 Interventional

Family-Based Protocol for Medication Integration in Treatment of Comorbid ASU/ADHD in Routine Care

NCT01539941
View directory record Official record
Conditions
Adolescent Substance Abuse, Attention Deficit Hyperactivity Disorder
Interventions
Medication integration protocol
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
13 Years to 17 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2015 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Results available

Community Trial in the Cherokee Nation

NCT04839978
View directory record Official record
Conditions
Opioid Abuse
Interventions
Connect Program, Communities Mobilizing for Change and Action (CMCA)
Behavioral
Lead sponsor
Emory University
Other
Eligibility
15 Years to 17 Years
Enrollment
919 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Tahlequah, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents

NCT01170260
View directory record Official record
Conditions
Risk Reduction Behavior, Health Behavior, Sexual Behavior, Adolescent Behavior, Cannabis
Interventions
INFORMATION-ONLY SEXUAL RISK REDUCTION (INFO-ONLY), SEXUAL PLUS ALCOHOL RISK REDUCTION (SRRI+ETOH), SEXUAL + ALCOHOL + MARIJUANA RISK REDUCTION
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
14 Years to 18 Years
Enrollment
460 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Sep 10, 2026, 6:35 AM EDT
Completed Not applicable Interventional Results available

Mobile Continuing Care Approach for Youth

NCT01632735
View directory record Official record
Conditions
Addiction
Interventions
Mobile Continuing Care
Behavioral
Lead sponsor
Azusa Pacific University
Other
Eligibility
12 Years to 24 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Azusa, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Sep 10, 2026, 6:35 AM EDT
Not listed Phase 2Phase 3 Interventional

A Comparison of Adolescent Group Therapy and Transitional Family Therapy for Adolescent Alcohol and Drug Abusers

NCT00484367
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence, Cannabis Abuse, Cannabis Dependence, Other Substance Abuse
Interventions
Adolescent group therapy, Transitional family therapy
Behavioral
Lead sponsor
The Morton Center, Inc.
Other
Eligibility
13 Years to 17 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2012
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 25, 2011 · Synced Sep 10, 2026, 6:35 AM EDT