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Showing 1–24 of 295 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adolescent Substance Use Clear all
Completed Not applicable Interventional Results available

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults

NCT02667119
View directory record Official record
Conditions
Substance Use Disorder, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure with Contingency Management, Standard Care
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 25 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
3
States / cities
Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional

EMA of Substance Use in Homeless Youth

NCT04884087
View directory record Official record
Conditions
Substance Use
Interventions
Ecological Momentary Assessment (EMA; Metricwire) Prompts 3x/day, Ecological Momentary Assessment (EMA; Metricwire) Prompts 6x/day, Incentive Structure - fixed, Incentive Structure - prize based
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
18 Years to 24 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Sep 5, 2026, 9:03 PM EDT
Not listed Phase 2 Interventional

The Aim of This Study is to Determine the Effectiveness of a Motivational Enhancement Intervention in Reducing Risk Behaviors (Drug and Alcohol Use, Sexual Risk Behavior, Poor Adherence to Medications) Among HIV+ Youth. - 1

NCT00227825
View directory record Official record
Conditions
Adherence, HIV Risk Behaviors, Alcohol & Drug Use, Health Behaviors, Sexual Risk Behaviors
Interventions
Motivational interviewing
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
16 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 5, 2026, 9:03 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Screening for Youth Alcohol and Drug Use: A Study of Primary Care Providers

NCT02408952
View directory record Official record
Conditions
Substance Related Disorders
Interventions
Primary Care Physician, Behavioral Medicine Specialist
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
12 Years to 80 Years
Enrollment
9,084 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2025
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2023 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional

Research on Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

NCT01117753
View directory record Official record
Conditions
Substance-Related Disorders, Depressive Disorder, Anxiety Disorder
Interventions
OutPatient Treatment for Adolescents (OPT-A), Treatment As Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
10 Years to 17 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 5, 2026, 9:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Primary Connections for Youth and Families

NCT05964010
View directory record Official record
Conditions
Substance Use
Interventions
Standard Screening, Standard Psychoeducation, Standard Brief Negotiated Interview (BNI), Standard Referral to Treatment (RT), Family Screening, Family Psychoeducation, Family Brief Negotiated Interview (BNI), Family Facilitated Conversation (FC) & Referral to Treatment (RT)
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
12 Years to 17 Years
Enrollment
2,300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional

Impact of Mindfulness Training on Adolescent Well-Being and Behavior

NCT05537961
View directory record Official record
Conditions
Substance Use, Mindfulness, Psychological Well-being
Interventions
Mindfulness-Oriented Recovery Enhancement
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
15 Years to 21 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gender-Responsive Drug Use Treatment for Juvenile Justice Girls

NCT02293057
View directory record Official record
Conditions
Drug Use
Interventions
VOICES Group, Girl Health Group
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 24 Years · Female only
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Southwest Hub for American Indian Youth Suicide Prevention Research

NCT03543865
View directory record Official record
Conditions
Suicide, Surveillance, Mental Health, Substance Use, Depressive Symptoms
Interventions
New Hope (NH), Elders Resilience (ER), Case Management (CM)
Behavioral · Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
16 Years to 29 Years
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 5, 2026, 9:03 PM EDT
Not yet recruiting Not applicable Interventional

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

NCT06965296
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
14 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing a Digital Intervention to Prevent Risky Health Behaviors

NCT06538922
View directory record Official record
Conditions
Substance Use
Interventions
Single Session Family Intervention
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
12 Years to 14 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Sep 5, 2026, 9:03 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Trial of Connecting to Promote Foster Teen Well-Being

NCT03157895
View directory record Official record
Conditions
Relationship, Family (Foster), Substance Use Prevention
Interventions
Connecting
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 15 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention

NCT03368456
View directory record Official record
Conditions
HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
Interventions
S4E, Usual Care
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 21 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Youth to Text or Telehealth for Engagement in HIV Care

NCT03681145
View directory record Official record
Conditions
HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Depression, Substance Use
Interventions
Counselor delivered telehealth intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 29 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 5, 2026, 9:03 PM EDT
Withdrawn Phase 4 Interventional

Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents

NCT01015066
View directory record Official record
Conditions
Opiate Addiction
Interventions
Buprenorphine/naloxone, Naltrexone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
16 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2014 · Synced Sep 5, 2026, 9:03 PM EDT
Not yet recruiting Not applicable Interventional

CBITS-RTM Pilot Study

NCT07682441
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, Substance Use
Interventions
Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention of Substance Use in Youth in Ukraine

NCT02347644
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Brief Motivational Interview
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 25 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Phase 1 Interventional

Intensive Outpatient Services for Teens

NCT01732601
View directory record Official record
Conditions
Depression, Suicide
Interventions
Intensive Outpatient CBT, Standard Care
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 18 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 5, 2026, 9:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adverse Adolescent Pathways to Substance Use

NCT06977178
View directory record Official record
Conditions
Anxiety, Adolescent Development, Substance Use
Interventions
Trier Social Stress Test
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
12 Years to 14 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Sep 5, 2026, 9:03 PM EDT
Not listed Not applicable Interventional

Computer-delivered Psychosocial Intervention for Adolescent Substance Use Disorders

NCT00957775
View directory record Official record
Conditions
Substance-Related Disorders, Alcohol-Related Disorders, Marijuana Abuse
Interventions
Usual care, Computer-delivered ACRA
Behavioral
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
12 Years to 18 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2009 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Not applicable Interventional Results available

Integrated Treatment for Adolescents With ADHD

NCT02420990
View directory record Official record
Conditions
ADHD, Substance Use Disorders
Interventions
Medication Integration Protocol (MIP), Changing Academic Support in the Home for Adolescents with ADHD (CASH-AA)
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
12 Years to 18 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Brief Substance Use Intervention for Youth in Teen Court

NCT01464554
View directory record Official record
Conditions
Alcohol or Other Drugs Use
Interventions
Usual care, Project Free Talk
Behavioral
Lead sponsor
RAND
Other
Eligibility
14 Years to 18 Years
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated May 7, 2015 · Synced Sep 5, 2026, 9:03 PM EDT
Enrolling by invitation Not applicable Interventional

Optimizing and Advancing SBIRT in Schools

NCT06206161
View directory record Official record
Conditions
Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
Interventions
Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 19 Years
Enrollment
21,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 5, 2026, 9:03 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Bupropion Treatment for Youth Smoking Cessation

NCT00344695
View directory record Official record
Conditions
Nicotine Dependence
Interventions
bupropion SR
Drug
Lead sponsor
University of Arizona
Other
Eligibility
14 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2003
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 26, 2006 · Synced Sep 5, 2026, 9:03 PM EDT