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ClinicalTrials.gov public records Last synced Oct 22, 2026, 5:10 AM EDT

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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Advance Directives Clear all
Completed Not applicable Interventional

Patient Understanding of End of Life Care

NCT01683097
View directory record Official record
Conditions
Advance Directives, Resuscitation Orders
Interventions
Standardized explanation
Other
Lead sponsor
Partners in Internal Medicine
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2012 · Synced Oct 22, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning

NCT04515810
View directory record Official record
Conditions
Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Hematologic Malignancy, Refractory Hematologic Malignancy
Interventions
Internet-Based Intervention, Best Practice, Telephone-Based Intervention, Questionnaire Administration, Post-intervention qualitative feedback interview
Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
4
States / cities
Manhasset, New York • New York, New York • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Advance Directives Completion Rates and an Intervention to Address Health Literacy in a Clinic Population

NCT02702284
View directory record Official record
Conditions
Health Literacy
Interventions
Advance Directives, Advance Directives without assistance
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
51 Years and older
Enrollment
529 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Results available

Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support

NCT03323502
View directory record Official record
Conditions
Alzheimer Disease, Dementia
Interventions
APPROACHES ACP Specialist Program, Standard of care
Behavioral · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
47,396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Warsaw, Indiana • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of an Easy to Read Advance Directive Versus a Standard Advance Directive

NCT00328055
View directory record Official record
Conditions
Aging
Interventions
AD-Easy (Advance Directive-Easy), AD-Standard (Advance Directive-Standard)
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
50 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2011 · Synced Oct 22, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparing the Stanford Letter Project Form to Traditional Advance Directives

NCT02799537
View directory record Official record
Conditions
Advance Directives, Palliative Care
Interventions
Randomized clinical study
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning

NCT06028152
View directory record Official record
Conditions
Breast Cancer, Lung Cancer, Genito Urinary Cancer
Interventions
End-of-life conversation game called "Hello"
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 22, 2026, 5:10 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Choice of Diction's Effect

NCT04896411
View directory record Official record
Conditions
Communication, Advance Directives, Decision Making, Cardiopulmonary Resuscitation
Interventions
Alternative phrasing for no code, Standard of care for no code
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 22, 2026, 5:10 AM EDT
Completed No phase listed Observational

Cardiopulmonary Resuscitation (CPR) Video to Enhance Advance Care Planning in Advanced Upper Gastrointestinal Cancer Patients

NCT01105806
View directory record Official record
Conditions
Pancreas and Hepatobiliary Cancer Patients
Interventions
(CPR) video and questionnaires, cardiopulmonary resuscitation (CPR) narrative script and questionnaires
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2015 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Study of Default Options in Advance Directives

NCT01817686
View directory record Official record
Conditions
COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy, Idiopathic Pulmonary Fibrosis, Other Interstitial Lung Disease Without Curative Therapy, Congestive Heart Failure, NYHA Class IV or NYHA Class III Plus 1 Hospitalization in the Past Year, Malignancy, Any Stage 3B or 4 Solid Tumor
Interventions
Comfort Default AD forms, Life Extension Default AD forms, Standard Default AD forms
Other
Lead sponsor
Corporal Michael J. Crescenz VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2015 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Comparison of a Web-based Advance Directive to a Standard Advance Directive

NCT03676426
View directory record Official record
Conditions
GI Cancer, Thoracic Cancer
Interventions
Web platform for advance care planning/advance directive, Standard advance directive
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2020 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Results available

The Influence of Default Options in Advance Directives

NCT01346176
View directory record Official record
Conditions
Advance Care Planning
Interventions
Advance Directive Forms
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
50 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 3, 2016 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

NCT06384417
View directory record Official record
Conditions
Breast Cancer, Lung Cancer, Genito-Urinary Cancer, Colorectal Cancer, Gastric Cancer, Pancreatic Cancer, Liver Cancer, Head and Neck Cancer, Melanoma
Interventions
Hello for Cancer game, Table Topics game
Behavioral · Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

UC Health Care Planning Study

NCT04012749
View directory record Official record
Conditions
Advance Care Planning, Advance Directives, Advanced Cancer
Interventions
Advance directive, Prepare, Facilitator
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
8,707 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
3
States / cities
Irvine, California • Los Angeles, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Nurse-led Patient-centered Advance Care Planning: A Pilot Study

NCT02302820
View directory record Official record
Conditions
Advance Care Planning, Nurse Care Coordination, Multiple Chronic Health Conditions
Interventions
Advance Care Planning Intervention
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2016 · Synced Oct 22, 2026, 5:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Advance Care Planning: Communicating With Outpatients for Vital Informed Decision

NCT04660422
View directory record Official record
Conditions
Advanced Care Planning, Shared Decision Making, Video Decision Aids, Communication Skills, Advance Directives, Natural Language Processing, Covid19
Interventions
VitalTalk communication skills training, ACP Decisions Video Program, Intervention training:, Medical Record Review
Other
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
65 Years and older
Enrollment
42,019 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Results available

Effect of an Advance Care Planning Intervention

NCT04852055
View directory record Official record
Conditions
Dementia
Interventions
Advance Care Planning Video
Behavioral
Lead sponsor
Brown University
Other
Eligibility
Not listed
Enrollment
2,364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Stillwater, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Patient Perception of Video Advance Care Planning

NCT02692950
View directory record Official record
Conditions
Advanced Directive Planning
Interventions
Honor My Decisions Advance Care Planning Video, Post-video questionnaire
Other · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 21, 2022 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Four Conversations RCT

NCT02944344
View directory record Official record
Conditions
Breast Cancer
Interventions
Four Conversations
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Advance Care Planning for Older Latinos With Chronic Illness

NCT06081660
View directory record Official record
Conditions
Patient Engagement, End of Life, Chronic Disease, Communication
Interventions
ACP-I Plan
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
50 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Results available

Impact of Active Choice on Advance Directive Completion Rates

NCT02289105
View directory record Official record
Conditions
Advance Directive Completion
Interventions
Mandatory active choice
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,279 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2017 · Synced Oct 22, 2026, 5:10 AM EDT
Completed No phase listed Observational

An Exploratory Study of the Use of Five Wishes as a Tool for Advanced Care Planning in Young Adults With Metastatic, Recurrent, or Progressive Cancer or HIV Infection

NCT01445145
View directory record Official record
Conditions
Neoplasms
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
16 Years to 30 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intervention to Improve Expression of End of Life Preferences for Homeless Persons

NCT00546884
View directory record Official record
Conditions
Healthy
Interventions
MI condition, GI
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
2
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Oct 22, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development of a Community Engagement Activity for Advance Care Planning

NCT02575417
View directory record Official record
Conditions
Chronic Disease
Interventions
Conversation Game
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 22, 2026, 5:10 AM EDT