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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adverse Childhood Experience Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Adversity, Brain and Opioid Use Study

NCT06355778
View directory record Official record
Conditions
Opioid Use Disorder, Healthy
Interventions
Magnetic Resonance Imaging (MRI), Computer Tasks
Other · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Evaluation of the Building Healthy Life Skills Program

NCT05611060
View directory record Official record
Conditions
Adverse Childhood Experiences, Housing Problems, Emotion Regulation
Interventions
Building Healthy Life Skills Program
Behavioral
Lead sponsor
University of California, Merced
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Merced, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pediatric ACEs Screening and Resiliency Study

NCT04182906
View directory record Official record
Conditions
Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection, Inflammatory Response, Self-regulation
Interventions
Care Coordination, Resiliency Clinic, Usual Care
Behavioral
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
3 Months to 11 Years
Enrollment
555 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP)

NCT04100577
View directory record Official record
Conditions
Infant Mortality, Infant Death, Racial Bias, Prenatal Stress, Prenatal Care, Maternal Child Health, Health Problems in Pregnancy, Adverse Childhood Experiences, Mental Health, Support Groups, Minority Health, Healthcare Disparities, Maternal-child Health Services, Social Determinants of Health, Trust, Physician-Patient Relations, Quality of Care
Interventions
Today Not Tomorrrow Pregnancy and Infant Support Program
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Sep 15, 2026, 10:53 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Adverse Childhood Experiences in Urogynecologic Patients

NCT03480477
View directory record Official record
Conditions
Pelvic Floor Disorders, Interstitial Cystitis, Urinary Incontinence
Interventions
ACE questionnaire
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
356 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Sep 15, 2026, 10:53 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

BLOOM: Boldly Living outdOOrs for Mental Health

NCT05973123
View directory record Official record
Conditions
Anxiety, Stress Disorder, Posttraumatic, Loneliness, Adverse Childhood Experiences
Interventions
Group Nature Outings, Family Outings
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
9 Years to 12 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

NCT06821035
View directory record Official record
Conditions
Adverse Childhood Experiences, Family Functioning
Interventions
Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
11 Years to 14 Years
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing a Scalable Model For ACEs-Related Care Navigation

NCT05567250
View directory record Official record
Conditions
Adverse Childhood Experiences, Child Development
Interventions
Behavioral: Telephone-based ACEs care coordination
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Up to 11 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity

NCT04818112
View directory record Official record
Conditions
Parent-Child Relations, Maternal Behavior, Infant Behavior
Interventions
ATVV, Attention control
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older · Female only
Enrollment
262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CEDARS Intervention: A Coping, Emotional Development, & Stress Reduction Intervention

NCT04958694
View directory record Official record
Conditions
Adolescent Behavior, Stress Reduction, Adverse Childhood Experiences, Positive Attitude
Interventions
CEDARS
Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
14 Years to 19 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Exercise on Young Adult Women With ACEs: an Integrative Pilot Study

NCT03521401
View directory record Official record
Conditions
Life Experiences
Interventions
Exercise
Behavioral
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 29 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

NCT07244809
View directory record Official record
Conditions
Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function, Oxidative Stress, Psychosocial Influence on Cardiovascular Disease
Interventions
Mitoquinone mesylate (MitoQ), Placebo
Dietary Supplement
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 29 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementation of Adverse Childhood Experiences (ACEs) Policy

NCT04916587
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Implementation Strategy of ACEs Screenings, Usual Care
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
0 Years to 5 Years
Enrollment
7,645 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Desert Hot Springs, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neurotrophic Indicators of Cognition, Executive Skills, Plasticity, and Adverse Childhood Experiences Study

NCT04076722
View directory record Official record
Conditions
Weight Loss, Wait-List Control
Interventions
Stress reactivity stimuli
Behavioral
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity

NCT04606199
View directory record Official record
Conditions
Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms, Signs and Symptoms, Psychological Distress, Psychological
Interventions
Mindfulness-based intervention, up to 5 minutes 0-3 times/day
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Building Resilient Families

NCT05388864
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Three-Tier Model
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
3 Years to 11 Years
Enrollment
340 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Impact of an Adapted Version of the Strengthening Families Program on IPV Among Caregivers and ACEs Among Children

NCT05129501
View directory record Official record
Conditions
Adverse Childhood Experiences, Domestic Violence
Interventions
Experimental
Behavioral
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
10 Years and older
Enrollment
318 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rapid City, South Dakota
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

NCT05665465
View directory record Official record
Conditions
Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Interventions
Nicotine nasal spray 0.5 mg, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 21 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Enrolling by invitation Not applicable Interventional

A Two-Part Intervention to Target Cardiovascular Health

NCT07673172
View directory record Official record
Conditions
Autism, Adverse Childhood Experience, Stress, Cardiovascular (CV) Risk
Interventions
Lifestyle Medicine, Cognitive Behavioral Therapy (CBT), Lifestyle Medicine with CBT Group
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
9 Years to 26 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional

Trauma-Informed Peer Aggression and Dating Violence Prevention for Preteens Receiving Intensive Mental Health Services

NCT06769282
View directory record Official record
Conditions
Aggression Childhood, Teen Dating Violence
Interventions
Experimental: Intervention (SPARE) plus Treatment as Usual, Treatment as Usual (TAU)
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
11 Years to 13 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Relationship of Adverse Childhood Experiences to Overweight and Obesity

NCT00632346
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Not listed
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 23 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2008 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

NCT06454344
View directory record Official record
Conditions
Adverse Childhood Experiences, Vascular Dilatation, Sleep, Sleep Disturbance, Psychosocial Stressor, Psychological Trauma, Endothelial Dysfunction, Inflammation, Oxidative Stress
Interventions
Cognitive Behavioral Therapy for Insomnia (CBT-i)
Behavioral
Lead sponsor
Nathaniel Jenkins
Other
Eligibility
18 Years to 29 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Sep 15, 2026, 10:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Childhood Trauma, Exercise, and Cognition

NCT05972265
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Moderate Intensity Exercise (one day), Placebo - Light Intensity Exercise (one day), Moderate Intensity Exercise (9 wks), Day 1 Assessments, Symptom Measures and Neuropsychological Tests, Day 36 Assessments, Day 57 Assessments, Day 78 Assessments
Behavioral · Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 15, 2026, 10:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Resilience Clinic Evaluation

NCT05690256
View directory record Official record
Conditions
Early Life Adversity, Caregiver Stress
Interventions
Resilience Clinic, Enhanced primary care
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
2 Years to 5 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
4
States / cities
Oakland, California • San Leandro, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 15, 2026, 10:53 AM EDT