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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adverse Childhood Experiences Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

School Violence Exposure as an Adverse Childhood Experience

NCT06153316
View directory record Official record
Conditions
Mental Health Outcomes, Adverse Childhood Experiences, Perceived School Safety, Educational Outcomes
Interventions
School shooting incident
Other
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
11 Years to 65 Years
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

NCT07244809
View directory record Official record
Conditions
Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function, Oxidative Stress, Psychosocial Influence on Cardiovascular Disease
Interventions
Mitoquinone mesylate (MitoQ), Placebo
Dietary Supplement
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 29 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementation of Adverse Childhood Experiences (ACEs) Policy

NCT04916587
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Implementation Strategy of ACEs Screenings, Usual Care
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
0 Years to 5 Years
Enrollment
7,645 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Desert Hot Springs, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional

Life Experiences in Adolescents and the Development of Skills

NCT04719897
View directory record Official record
Conditions
Depression in Adolescence, Adverse Childhood Experiences
Interventions
FIRST: Repairing Thoughts
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 15 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional

Shaping Actions and Responses to Emotions

NCT04719949
View directory record Official record
Conditions
Depression in Adolescence, Adverse Childhood Experiences
Interventions
Behavioral Activation (BA) Therapy, Problem Solving Therapy (PST)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 15 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Jul 21, 2026, 9:37 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Calling All Dads! Evaluation of APAs ACT Program: Engaging Fathers to Prevent Adverse Childhood Experiences

NCT06075446
View directory record Official record
Conditions
Child Abuse
Interventions
ACT Raising Safe Kids
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
18 Years and older · Male only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Building Resilient Families

NCT05388864
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Three-Tier Model
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
3 Years to 11 Years
Enrollment
340 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 21, 2026, 9:37 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Adverse Childhood Experiences in Urogynecologic Patients

NCT03480477
View directory record Official record
Conditions
Pelvic Floor Disorders, Interstitial Cystitis, Urinary Incontinence
Interventions
ACE questionnaire
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
356 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adversity, Brain and Opioid Use Study

NCT06355778
View directory record Official record
Conditions
Opioid Use Disorder, Healthy
Interventions
Magnetic Resonance Imaging (MRI), Computer Tasks
Other · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 9:37 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition

NCT06269614
View directory record Official record
Conditions
Autism Spectrum Disorder, Adverse Childhood Experiences, Stress Reaction
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Nova Southeastern University
Other
Eligibility
4 Years to 95 Months
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Davie, Florida
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Exercise on Young Adult Women With ACEs: an Integrative Pilot Study

NCT03521401
View directory record Official record
Conditions
Life Experiences
Interventions
Exercise
Behavioral
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 29 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

NCT06454344
View directory record Official record
Conditions
Adverse Childhood Experiences, Vascular Dilatation, Sleep, Sleep Disturbance, Psychosocial Stressor, Psychological Trauma, Endothelial Dysfunction, Inflammation, Oxidative Stress
Interventions
Cognitive Behavioral Therapy for Insomnia (CBT-i)
Behavioral
Lead sponsor
Nathaniel Jenkins
Other
Eligibility
18 Years to 29 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional

Caregiver Adverse Childhood Experiences (ACEs) in Pediatric Primary Care

NCT05013138
View directory record Official record
Conditions
Child Development
Interventions
Training for ACEs and study procedures, Training on study procedures
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chamblee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examine the Effects of Mindfulness in Woman With a History of Child Adversity

NCT05255380
View directory record Official record
Conditions
Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms, Signs and Symptoms
Interventions
Mindfulness and compassion-based practices; approximately 5-10 minutes two times/day, Mindful awareness and reporting of current thoughts and feelings, 2 times/day
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Years to 50 Years · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Evaluation of the Building Healthy Life Skills Program

NCT05611060
View directory record Official record
Conditions
Adverse Childhood Experiences, Housing Problems, Emotion Regulation
Interventions
Building Healthy Life Skills Program
Behavioral
Lead sponsor
University of California, Merced
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Merced, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

ACEs, SIRT1, and Premature Vascular Aging in Humans

NCT07073352
View directory record Official record
Conditions
Adverse Childhood Experiences, Endothelial Dysfunction
Interventions
Nicotinamide Riboside, Placebo
Dietary Supplement
Lead sponsor
Nathaniel Jenkins
Other
Eligibility
18 Years to 30 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healing Experiences of Adversity Among Latinos (HEALthy4You)

NCT05676281
View directory record Official record
Conditions
Stress, Childhood Obesity
Interventions
Healthy Together (Control), Healthy Together + Promotora Support, Healthy Together + Parenting Training, Healthy Togethers + Parenting Training + Promotora support
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
5 Years to 11 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Building Resilience Program: Examining Self-Regulation, Behavior, and Resilience in Under-Resourced Preschoolers With ACEs

NCT07170605
View directory record Official record
Conditions
Preschool Age Children, Preschool Education, Adverse Childhood Experience, Mental Health, Resilience, Minority Groups
Interventions
Mental health, positive coping strategies promoting self-regulation and adaptive skills, Standard care/School Readiness Condition
Behavioral · Other
Lead sponsor
Cleveland State University
Other
Eligibility
24 Months to 66 Months
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Childhood Trauma, Exercise, and Cognition

NCT05972265
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Moderate Intensity Exercise (one day), Placebo - Light Intensity Exercise (one day), Moderate Intensity Exercise (9 wks), Day 1 Assessments, Symptom Measures and Neuropsychological Tests, Day 36 Assessments, Day 57 Assessments, Day 78 Assessments
Behavioral · Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 9:37 AM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers Results available

Physical Exercise for Augmenting Cognitive Health (PEACH)

NCT04922710
View directory record Official record
Conditions
Cognitive Aging, Adverse Childhood Experiences
Interventions
Home-based aerobic exercise
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
30 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Jul 21, 2026, 9:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

NCT06821035
View directory record Official record
Conditions
Adverse Childhood Experiences, Family Functioning
Interventions
Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
11 Years to 14 Years
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 21, 2026, 9:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Journey of Hope in Appalachia: Supporting Resilience in the Region's Youth

NCT04096937
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Focus groups
Other
Lead sponsor
Gia Mudd
Other
Eligibility
10 Years to 99 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Hazard, Kentucky • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Nov 24, 2022 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Resilience Clinic Evaluation

NCT05690256
View directory record Official record
Conditions
Early Life Adversity, Caregiver Stress
Interventions
Resilience Clinic, Enhanced primary care
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
2 Years to 5 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
4
States / cities
Oakland, California • San Leandro, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Jul 21, 2026, 9:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP)

NCT04100577
View directory record Official record
Conditions
Infant Mortality, Infant Death, Racial Bias, Prenatal Stress, Prenatal Care, Maternal Child Health, Health Problems in Pregnancy, Adverse Childhood Experiences, Mental Health, Support Groups, Minority Health, Healthcare Disparities, Maternal-child Health Services, Social Determinants of Health, Trust, Physician-Patient Relations, Quality of Care
Interventions
Today Not Tomorrrow Pregnancy and Infant Support Program
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Jul 21, 2026, 9:37 AM EDT