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ClinicalTrials.gov public records Last synced Sep 9, 2026, 7:24 AM EDT

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Showing 1–24 of 52 matching trials from the live ClinicalTrials.gov search.
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Conditions
Mobility Limitation, Cognitive Impairment
Interventions
Neurorehabilitation of Standard Walking, Neurorehabilitation of Complex Walking, Sham Transcranial Direct Current Stimulation (Sham tDCS), Active Transcranial Direct Current Stimulation (Active tDCS)
Behavioral · Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 110 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
3
States / cities
Gainesville, Florida
Conditions
Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
Interventions
Cognitive Training, Computerized Cognitive Stimulation
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
55 Years to 89 Years
Enrollment
1,305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
6
States / cities
San Francisco, California • Gainesville, Florida • Tampa, Florida + 3 more
Conditions
Mild Cognitive Impairment, Chronic Kidney Diseases
Interventions
Home-based walking exercise, Attention control
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
55 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Washington D.C., District of Columbia • New York, New York
Conditions
Cognitive Decline, Age-Related Memory Disorders, Postoperative Complications, Age-Related Atrophy, Postoperative Cognitive Dysfunction
Interventions
Exercise Intervention
Other
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Not listed Phase 2 Interventional Accepts healthy volunteers

n-3 PUFA for Vascular Cognitive Aging

NCT01953705
Conditions
Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction, Executive Dysfunction
Interventions
Omega 3 PUFA, Placebo
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
75 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Conditions
Age-Related Cognitive Decline, Age-Related Memory Disorders
Interventions
DHA (nutritional supplement) or placebo
Dietary Supplement
Lead sponsor
dsm-firmenich Switzerland AG
Industry
Eligibility
55 Years and older
Enrollment
485 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
14
States / cities
Mesa, Arizona • San Diego, California • Vista, California + 11 more
Completed Not applicable Interventional Accepts healthy volunteers

Acute Raspberry Intake on Metabolic Control and Cognitive Function

NCT03743792
Conditions
Aging, Age-related Cognitive Decline, Obesity
Interventions
Active breakfast, Control breakfast
Dietary Supplement
Lead sponsor
USDA Human Nutrition Research Center on Aging
Federal
Eligibility
55 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Recruiting Not applicable Interventional Accepts healthy volunteers

Cardiac-Control Affecting Learning Through Mindfulness (CALM)

NCT06410157
Conditions
Age-related Cognitive Decline, Alzheimer Disease
Interventions
Daily practice
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
50 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Age-Related Memory Disorders
Interventions
ispronicline (nicotinic acetylcholine receptor agonist)
Drug
Lead sponsor
Targacept Inc.
Industry
Eligibility
50 Years to 80 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
15
States / cities
Mesa, Arizona • Peoria, Arizona • Denver, Colorado + 12 more
Recruiting Phase 1 Interventional Accepts healthy volunteers

Acute Effects of THC in Older Adult

NCT06948136
Conditions
Age-related Cognitive Decline
Interventions
Delta-9-THC Low Dose, Placebo, Delta-9-THC Medium Dose
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Conditions
Age-Related Memory Disorders
Interventions
Transdermal nicotine patch, Placebo transdermal patch
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years to 90 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Durham, North Carolina • Burlington, Vermont
Completed Not applicable Interventional Accepts healthy volunteers

Improving Working Memory in Older Adults

NCT04362696
Conditions
Memory Disorders in Old Age
Interventions
High definition transcranial electrical current stimulation
Device
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 80 Years
Enrollment
964 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline

NCT01746303
Conditions
Age-related Memory Disorders, Mood Disorders
Interventions
Omega-3 fatty acid, Blueberry powder, Placebo oil, Placebo powder
Dietary Supplement · Other
Lead sponsor
University of Cincinnati
Other
Eligibility
62 Years to 80 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Intermittent Fasting on Brain Health

NCT06019195
Conditions
Intermittent Fasting, Aging
Interventions
Time restricted eating
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
55 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Daily Mixed Spice Consumption on Memory Function

NCT06889961
Conditions
Memory, Cognitive Function
Interventions
Mixed spices, Placebo
Dietary Supplement · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Completed Not applicable Interventional Accepts healthy volunteers

Exercise, Age-Related Memory Decline, And Hippocampal Function

NCT01329653
Conditions
Cognitive Deterioration, Disorder of Aging
Interventions
aerobic training, Wait list
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
20 Years to 75 Years
Enrollment
233 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
New York, New York
Conditions
Age-related Cognitive Decline
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Iowa City, Iowa • Boston, Massachusetts
Conditions
Age Related Cognitive Decline
Interventions
PATH neurotraining, Orientation Discrimination
Behavioral
Lead sponsor
Perception Dynamics Institute
Industry
Eligibility
55 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
La Jolla, California • Solana Beach, California
Conditions
Hypertension
Interventions
High Intensity Interval Training (HIIT) Exercise
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
55 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Not listed No phase listed Observational Accepts healthy volunteers

Alzheimer's Disease Core Center

NCT01421420
Conditions
Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Memory Disorders
Interventions
Not listed
Lead sponsor
University of Arizona
Other
Eligibility
50 Years and older
Enrollment
900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Multi-Tasking Training in Healthy Older Adults

NCT04195230
Conditions
Age-related Cognitive Decline
Interventions
Multi-tasking Training
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
60 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Conditions
Alzheimer Disease, Alzheimer Dementia, Vascular Dementia, Lewy Body Disease, Lewy Body Dementia With Behavioral Disturbance (Disorder), Dementia, Mixed, Parkinson-Dementia Syndrome, Chronic Traumatic Encephalopathy, Huntington's Dementia, Wernicke Korsakoff Syndrome, Traumatic Brain Injury, Dementia, Multi-Infarct, Autism, Autism Spectrum Disorder, Autistic Behavior, Autistic Disorder, Current or Active State, Cadasil, LATE Limbic-predominant Age-related TDP-43 Encephalopathy
Interventions
Intravenous Bone Marrow Stem Cell (BMSC) Fraction, Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction, Near Infrared Light
Procedure
Lead sponsor
MD Stem Cells
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
Westport, Connecticut • Coral Springs, Florida
Recruiting Not applicable Interventional Accepts healthy volunteers

Cognition, Flavonoids, Exercise, Gut Microbiome

NCT06495190
Conditions
Cognitive Decline, Mild
Interventions
Blueberry, Walking, Placebo, Stretching
Dietary Supplement · Behavioral
Lead sponsor
Appalachian State University
Other
Eligibility
65 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Kannapolis, North Carolina
Recruiting Not applicable Interventional Accepts healthy volunteers

Health Ahead Comparative Effectiveness Study

NCT07669168
Conditions
Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services, Patient Participation, Health Behavior, Aging, Cardiovascular Diseases, Metabolic Syndrome, Cognitive Dysfunction, Frailty, Activities of Daily Living, Health Related Quality of Life, Health Equity, Telemedicine
Interventions
AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
Behavioral
Lead sponsor
William Brandenburg, MD
Industry
Eligibility
18 Years and older
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2099
U.S. locations
1
States / cities
Boulder, Colorado