Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 25, 2026, 8:40 AM EDT

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Showing 529–552 of 1,647 matching trials from the live ClinicalTrials.gov search.
Conditions
Skin Aging
Interventions
Investigational Facial Serum #3, Investigational Facial Serum #1, Investigational Facial Serum #2
Other
Lead sponsor
Victoria Collotta
Industry
Eligibility
35 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Needham, Massachusetts
Completed Phase 2 Interventional Accepts healthy volunteers

Study of Pomegranate Juice on Memory in Older Adults

NCT02093130
Conditions
Impact of Pomegranate Juice on Memory in Older Adults
Interventions
Pomegranate Juice, Placebo
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 75 Years
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Completed Phase 2 Interventional Accepts healthy volunteers

Everolimus Aging Study

NCT05835999
Conditions
Aging, Insulin Resistance
Interventions
Everolimus 0.5 MG once per day, Everolimus 5 MG once per week, Placebo once per day, Placebo once per week
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Aging With a Ketone Ester for Function in Frailty

NCT06645847
Conditions
Frail Elderly, Aging, Immune Function, Muscle Function
Interventions
Ketone ester, Placebo Comparator: Non-ketone placebo
Other
Lead sponsor
Buck Institute for Research on Aging
Other
Eligibility
65 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
3
States / cities
Novato, California • Farmington, Connecticut • Columbus, Ohio
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock

NCT04608448
Conditions
Aging, Epigenetics, Inflammatory Mediators
Interventions
Rapamycin Topical Ointment, Placebo
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
65 Years to 95 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Completed Not applicable Interventional Accepts healthy volunteers Results available

Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep

NCT00732199
Conditions
Sleep Apnea, Age
Interventions
1) hyperventilation via noninvasive positive pressure ventilation 2) multiple trials of episodic hypoxia
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
1
States / cities
Detroit, Michigan
Completed No phase listed Observational Accepts healthy volunteers

Insulin Resistance and Accelerated Cognitive Aging

NCT03039647
Conditions
Insulin Resistance
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
25 Years to 50 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Stanford, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Revitalize Cognition: Near Infrared Stimulation in Older Adults

NCT02582593
Conditions
Aging
Interventions
MedX 1116 Rehab Console, Sham MedX 1116 Rehab Console
Device
Lead sponsor
University of Florida
Other
Eligibility
62 Years to 99 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
2
States / cities
Gainesville, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aerobic Exercise and Cerebrovascular Function

NCT03803904
Conditions
Aging
Interventions
Spin
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Decatur, Georgia
Conditions
Acute Myocardial Infarction
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
75 Years and older
Enrollment
3,042 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
81
States / cities
Fort Smith, Arkansas • Los Alamitos, California • Sacramento, California + 70 more
Conditions
Breast Cancer
Interventions
Engagement in Physical Activity, Questionnaires
Behavioral · Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years to 99 Years · Female only
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Aging
Interventions
Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions, Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years to 85 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Completed No phase listed Observational Accepts healthy volunteers

PUER ("Previously Unrecognized Emerging Risks") Life Clinical Study

NCT05687578
Conditions
Aging
Interventions
Measurements Only
Diagnostic Test
Lead sponsor
Puer Research, LLC
Network
Eligibility
18 Years to 90 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Completed Not applicable Interventional Accepts healthy volunteers

The Efficacy of Fenugreek Supplementation on Men's Health

NCT03528538
Conditions
Aging, Testosterone Deficiency
Interventions
AlphaFen fenugreek 400 mg, AlphaFen fenugreek 500 mg, Placebo
Dietary Supplement · Other
Lead sponsor
Jacksonville University
Other
Eligibility
21 Years to 45 Years · Male only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Jacksonville, Florida
Conditions
Diabetes, Hypoglycemia, Aging
Interventions
Not listed
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
65 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Multimodal Physiologic State Intelligence Study

NCT07814118
Conditions
Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute, Myocarditis Due to Drug, Myocarditis Viral, Pericardial Diseases, Valvular Heart Diseases, Hypertension, Sepsis, Acute Kidney Injury, Pulmonary Edema - Acute, Pulmonary Edema With Heart Failure, Pulmonary Edemas, Acute Respiratory Distress Syndrome, Pulmonary Embolism Acute, Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute Massive, Pulmonary Embolism Subacute Massive, Venous Thrombosis Pulmonary, Venous Thrombosis (Disorder), Venous Thrombosis, Deep, Peripheral Arterial Disease, Peripheral Arterial Disease (PAD), Aortic Diseases, Muskuloskeletal Diseases, Brain Aging, Brain Aneurysm, Brain Aging Related Conditions, Ultrasound, Ultrasound Exams, Ultrasound Guidance
Interventions
OMNIPHYS Multimodal Ultrasound Imaging System
Device
Lead sponsor
Truway Health, Inc.
Industry
Eligibility
18 Years and older
Enrollment
25,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2046
U.S. locations
1
States / cities
New York, New York
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Metformin in Longevity Study (MILES).

NCT02432287
Conditions
Aging
Interventions
Metformin, Placebo
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
The Bronx, New York
Conditions
Dementia, Staff Attitude, Nurse's Role, Nursing Homes
Interventions
DIGNITY, Infection Control
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
State College, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers Results available

Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease

NCT04299308
Conditions
Healthy Aging, Alzheimer Disease
Interventions
Aerobic Exercise
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Conditions
Cancer
Interventions
Holistic Intervention
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
San Antonio, Texas
Completed Not applicable Interventional Accepts healthy volunteers

Ketone Ester Supplementation and Nocturnal Blood Pressure

NCT05888506
Conditions
Cardiovascular Diseases in Old Age, Aging, Cardiovascular Diseases, Sleep
Interventions
Ketone Ester, Placebo
Dietary Supplement
Lead sponsor
Georgia Southern University
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Savannah, Georgia
Conditions
Wrinkle
Interventions
Restylane® Silk
Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Diego, California
Completed Not applicable Interventional Results available

Orthostatic Hypotension in Rehabilitation Patients

NCT00117585
Conditions
Hypotension, Orthostatic
Interventions
Treatment Phase 1, Treatment Phase 2, Treatment Phase 3
Other · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
341 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Portland, Oregon
Not listed Not applicable Interventional Accepts healthy volunteers

Enhancing Resilience in Senior Living Community Residents

NCT04720014
Conditions
Stress, Psychological, Coping Skills
Interventions
SMART-3RP Group Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts