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ClinicalTrials.gov public records Last synced Oct 24, 2026, 3:59 AM EDT

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Showing 217–240 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Recruiting Not applicable Interventional

Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

NCT06513156
View directory record Official record
Conditions
Opioid Use Disorder, Injection Related Infections, Stimulant Use Disorder
Interventions
Integrated Infectious Diseases and Substance Use Disorder Clinic (IC)
Behavioral
Lead sponsor
Elana Rosenthal
Other
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Baltimore, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 24, 2026, 3:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)

NCT06501781
View directory record Official record
Conditions
HIV Infections, Substance Use
Interventions
Peer Activate-LAI, Standard of Care HIV treatment or prevention with LAI-PrEP/ART
Behavioral · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional

A Brief Intervention for Alcohol Users With Interpersonal Trauma

NCT05414344
View directory record Official record
Conditions
Heavy Drinking, Alcohol Drinking, Substance Use, Drinking Behavior
Interventions
Standard Brief Intervention, Trauma-Informed and Peer-Supported Brief Intervention, Assessment only
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
18 Years to 25 Years
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 24, 2026, 3:59 AM EDT
Recruiting Not applicable Interventional

The Trans-Led Care Study

NCT06880705
View directory record Official record
Conditions
Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol), Human Immunodeficiency Virus (HIV)
Interventions
The TLC Program
Behavioral
Lead sponsor
Illinois Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional Results available

Technological Intervention for Reducing Alcohol Use Among People Living With HIV/AIDS

NCT03746600
View directory record Official record
Conditions
Acquired Immunodeficiency Syndrome, HIV/AIDS, Alcohol Drinking
Interventions
Project TRAC: Tracking and Reducing Alcohol Consumption
Behavioral
Lead sponsor
Carolyn Lauckner
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 24, 2026, 3:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Family Risk Analysis of Substance Use in Attention Deficit Hyperactivity Disorder (ADHD) Youth Treated With Concerta

NCT00181792
View directory record Official record
Conditions
ADHD, Smoking
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
6 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 4, 2012 · Synced Oct 24, 2026, 3:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Neuroeconomics of Behavioral Therapies for Adolescent Substance Abuse

NCT01093898
View directory record Official record
Conditions
Adolescent Substance Use
Interventions
Not listed
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
12 Years to 18 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Phase 1 Interventional

Mindful Awareness in Body-Oriented Therapy for Women's Substance Abuse Treatment

NCT01280916
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Mindful Awareness in Body-oriented Therapy
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Kirkland, Washington
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Oct 24, 2026, 3:59 AM EDT
Enrolling by invitation Not applicable Interventional

Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

NCT07527871
View directory record Official record
Conditions
Substance Use (Drugs, Alcohol)
Interventions
ED-SMART intervention, Substance use information
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional Results available

Train Your Brain: A Pilot Project to Improve Memory and Decision Making

NCT05879198
View directory record Official record
Conditions
Behavior, Health
Interventions
Computer-based Intervention
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
12 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
Detroit, Michigan • Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 28, 2025 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

NCT02322047
View directory record Official record
Conditions
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone)
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional Results available

Prolonged Exposure Therapy for PTSD and Opioid Use Disorder

NCT04104022
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Opioid-use Disorder
Interventions
Prolonged Exposure Therapy, Attendance-based monetary incentives
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Phase 4 Interventional Results available

Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

NCT02845453
View directory record Official record
Conditions
Substance Use Disorders, Bipolar Disorder, Mood Disorders
Interventions
Quetiapine, Placebo
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
15 Years to 24 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional Results available

Pilot: Digital Therapeutic vs Education for the Management of Problematic Substance Use

NCT04974645
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Substance Use Disorders
Interventions
W-SUDs, Digitally-delivered Psychoeducation
Device · Other
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2024 · Synced Oct 24, 2026, 3:59 AM EDT
Not yet recruiting Not applicable Interventional

Improving HIV Prevention and Substance Use Post-Sexual Assault Services

NCT07225062
View directory record Official record
Conditions
HIV Infections, Substance Use, Sexual Assault
Interventions
Enhanced intervention, Usual Care
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
17 Years to 25 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 24, 2026, 3:59 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Emergency Medicine Peer Outreach Worker Engagement for Recovery

NCT06320015
View directory record Official record
Conditions
Substance Use Disorders, Overdose, Opioid Use Disorder, Alcohol Use Disorder
Interventions
Substance Misuse Assistance Response Team (SMART), Usual Care Group
Behavioral · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional

Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)

NCT01365247
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Interventions
Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2015 · Synced Oct 24, 2026, 3:59 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

ANCHORS Alcohol & Sexual Health Study: UH3 Project

NCT04331704
View directory record Official record
Conditions
Alcohol Use, Unspecified, Substance Use, Sex Behavior
Interventions
PrEP acronym (pre-exposure prophylaxis), Initial Web Survey, Interactive Voice Response (IVR) monitoring, Educational material on alcohol and sexual health behavior, Interactive Voice Response (IVR) assessment with personalized information, Personalized information based on web-based survey responses & standardized information
Drug · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Smoking Cessation for Young Adults Who Binge Drink - 1

NCT00218452
View directory record Official record
Conditions
Adherence, Tobacco Use Cessation, Alcohol & Drug Use, Nicotine Transdermal System
Interventions
Lifestyle counseling
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 25 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
3
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 24, 2026, 3:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)

NCT07525258
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol-associated Liver Disease
Interventions
Implementation Intervention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

15 Year Follow-up of New Beginnings Program for Divorced Families

NCT01407120
View directory record Official record
Conditions
Mental Disorder, Substance Use
Interventions
New Beginnings Program
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
9 Years to 12 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 2, 2011 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional

Martial Arts as Early Intervention for Teen Drug Abuse

NCT00956527
View directory record Official record
Conditions
Adolescent, Substance Use
Interventions
Modified traditional martial arts training
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 20, 2013 · Synced Oct 24, 2026, 3:59 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking

NCT07264582
View directory record Official record
Conditions
HIV Testing, STI, HCV, Overdose, Drug
Interventions
Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 24, 2026, 3:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform

NCT05476588
View directory record Official record
Conditions
Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
Interventions
Screening
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 24, 2026, 3:59 AM EDT