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ClinicalTrials.gov public records Last synced Oct 24, 2026, 10:21 AM EDT

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Showing 337–360 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Recruiting Phase 2 Interventional

Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder

NCT06444256
View directory record Official record
Conditions
Stimulant Use Disorder
Interventions
SUVO, TAU
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smartphone Addiction Recovery Coach for Young Adults (SARC-YA) Experiment

NCT03301012
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Recovery support as usual, Smartphone assisted relapse prevention
Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years to 26 Years
Enrollment
237 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
Bloomington, Illinois • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 30, 2024 · Synced Oct 24, 2026, 10:21 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

mHealth Service Linkage for Young Adults Impacted by the Criminal Legal System

NCT07599722
View directory record Official record
Conditions
HIV Prevention, Substance Use
Interventions
LYNX, Standard of Care
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 29 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories

NCT00247572
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
Interventions
NRP104
Drug
Lead sponsor
New River Pharmaceuticals
Industry
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2007 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional Results available

Innovative Digital Therapeutic for Smoking Cessation

NCT03694327
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence, Tobacco Dependence, Tobacco Use Disorder, Substance Use Disorder, Tobacco Smoking
Interventions
CT-101-M, QuitGuide
Device
Lead sponsor
My Digital Study
Industry
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness for at Risk Youth: Understanding Substance Use and Important Mechanisms of Change

NCT04160754
View directory record Official record
Conditions
Alcohol Use, Underage, Alcohol Problem Drinking, Substance Use
Interventions
Mindfulness Based Relapse Prevention, Control (CTL)
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 26 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional

Alliances to Disseminate Addiction Prevention and Treatment (ADAPT)

NCT04499079
View directory record Official record
Conditions
Substance-Related Disorders, Recidivism, Opioid-Related Disorders, Substance Use, Criminal Behavior
Interventions
Learning Health System
Other
Lead sponsor
Indiana University
Other
Eligibility
11 Years and older
Enrollment
7,316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Completed No phase listed Observational

Healthcare Provider Attitudes Towards Patients With Substance Use Before and After Implementation of the SBIRT Model in the Emergency Room

NCT01661478
View directory record Official record
Conditions
Patients With Substance Abuse, Healthcare Provider Attitudes
Interventions
Training on motivational interviewing
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 18, 2017 · Synced Oct 24, 2026, 10:21 AM EDT
Enrolling by invitation No phase listed Observational

Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl

NCT06995885
View directory record Official record
Conditions
Substance Use Disorders (SUDs)
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional

Behavioral Incentives to Increase Exercise in Cocaine Dependent Women

NCT01283191
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Behavioral Incentives, Education Control
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Phase 1Phase 2 Interventional

Psychological First Aid for Victims of Crime

NCT01934348
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Substance Use
Interventions
Psychological First Aid, Usual victim advocacy Services
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention of Substance Use in Youth in Ukraine

NCT02347644
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Brief Motivational Interview
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 25 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Oct 24, 2026, 10:21 AM EDT
Recruiting Not applicable Interventional

OurRelationship-S: A Digital Relationship-Strengthening Program for Couples Experiencing Substance Misuse

NCT07159633
View directory record Official record
Conditions
Relationship Conflict, Relationship Distress
Interventions
Online Couple Intervention
Behavioral
Lead sponsor
OurRelationship
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
5
States / cities
Marietta, Georgia • Elkton, Maryland • Potsdam, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Oct 24, 2026, 10:21 AM EDT
Not yet recruiting Phase 1 Interventional

Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)

NCT06868914
View directory record Official record
Conditions
Healthy Volunteers
Interventions
TMS (MagVenture MagPro 100 with MagOption)
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
22 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Hartford, Connecticut • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Not listed Not applicable Interventional

Floatation-REST in Methamphetamine Use Disorder: A Pilot Study

NCT05799209
View directory record Official record
Conditions
Amphetamine-Type Substance Use Disorder
Interventions
Float Pool, Float Chair
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder

NCT05872386
View directory record Official record
Conditions
Telehealth at the Library, Control Group
Interventions
Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Completed No phase listed Observational

Characterization of Phenotypic and Genotypic Regressors for Imaging

NCT01148381
View directory record Official record
Conditions
Healthy Volunteers, Substance Use Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
847 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional

Enhancing Early-Phase Care for Primary Care Patients With Unhealthy Substance Use

NCT01887665
View directory record Official record
Conditions
Substance Use Disorders
Interventions
incentives
Behavioral
Lead sponsor
Brandeis University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional

Development and Testing of Adolescent Twelve-Step Facilitation

NCT01449981
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence, Drug Abuse, Drug Dependence
Interventions
Integrated Twelve-Step Facilitation, Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 21 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2016 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional

Exercise: Addressing Stress in Relapse Prevention for Substance Use Disorders

NCT01828307
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Motivational enhancement therapy (MET), Contingency management, Standard Aftercare Treatment
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants

NCT06316973
View directory record Official record
Conditions
Substance Use Disorders, Methamphetamine Abuse, Methamphetamine Intoxication
Interventions
CS-1103, Sterile Saline
Drug
Lead sponsor
Clear Scientific, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the PrEP Care Cascade Among Black Men and Transwomen in the Southeastern US

NCT04832477
View directory record Official record
Conditions
HIV Seropositivity, Substance Use, STI, Stigma, Social
Interventions
Stigma counseling for PrEP use
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older · Male only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Completed Not applicable Interventional

Wellness, Intervention Strategies and HIV Care

NCT07069374
View directory record Official record
Conditions
HIV, Substance Use Disorder (SUD)
Interventions
Wellness, Intervention Strategies and HIV Care (WISH), Movie Night Club - Attention and Time Matched Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Oakland, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 24, 2026, 10:21 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

90-Day Online Substance Use Program

NCT03069118
View directory record Official record
Conditions
Addictive Behavior, Alcohol Use Disorder, Alcohol Abuse, Drug Abuse, Drug Use Disorders
Interventions
Treatment - Workit Health Online Program, Control - Resource List
Behavioral
Lead sponsor
Workit Health
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Oct 24, 2026, 10:21 AM EDT