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ClinicalTrials.gov public records Last synced Oct 24, 2026, 4:04 PM EDT

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Showing 409–432 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Completed Not applicable Interventional Results available

Pragmatic RCT of SBIRT-PM

NCT04062214
View directory record Official record
Conditions
Substance Use Disorders, Pain
Interventions
SBIRT-PM
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 100 Years
Enrollment
1,101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
9
States / cities
New Haven, Connecticut • West Haven, Connecticut • Augusta, Maine + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of an Entrepreneurship Program for American-Indian Youth

NCT02157493
View directory record Official record
Conditions
Depressive Symptoms, Substance Use
Interventions
Arrowhead Business Group Curriculum, Recreational League Control Condition
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
13 Years to 15 Years
Enrollment
449 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Employing eSBI in HIV Testing for At-risk Youth

NCT02703116
View directory record Official record
Conditions
HIV, Substance Use
Interventions
Alcohol Use BI, Nutrition Intervention
Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
16 Years to 25 Years
Enrollment
464 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
3
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 15, 2021 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use

NCT01621334
View directory record Official record
Conditions
Domestic Violence, Substance Abuse
Interventions
Motivational Enhancement Therapy, Educational information
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Male only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 18, 2012 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional

Impact of Stress First Aid for Workers in Substance Misuse Settings

NCT07177014
View directory record Official record
Conditions
Occupational Health
Interventions
Stress First Aid (SFA)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 100 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Phase 4 Interventional Results available

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

NCT03526354
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
Interventions
Brexpiprazole, Treatment as Usual
Drug · Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
4
States / cities
Augusta, Georgia • Boston, Massachusetts • Worcester, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 23, 2025 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional

Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START

NCT07278427
View directory record Official record
Conditions
Substance Use Disorder (SUD), Rural Health, Family Resilience, Child Maltreatment, Child Well-beiing, Substance Use Recovery
Interventions
Ohio START (Ohio Sobriety, Treatment, and Reducing Trauma)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional

WORTH Paths Intervention

NCT06889831
View directory record Official record
Conditions
Substance Use Disorder (SUD), Sexual and Reproductive Health, Sexual Risk Behavior
Interventions
WORTH Paths Digital Intervention, WORTH Paths Wellness Group
Behavioral
Lead sponsor
Fairleigh Dickinson University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Teaneck, New Jersey
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mobile Enhanced Prevention Support for People Leaving Jail

NCT04036396
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases, Bacterial, Hepatitis C, Substance Use Disorders
Interventions
Mobile Enhanced Prevention Support, Usual Care plus Customized Referrals
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 49 Years · Male only
Enrollment
233 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
3
States / cities
Los Angeles, California • Santa Fe Springs, California
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Implementing a Pharmacist-Integrated Collaborative Model of Medication Treatment for Opioid Use Disorder

NCT05310786
View directory record Official record
Conditions
Opioid Use Disorder, Substance Use Disorders
Interventions
Pharmacist-integrated Medication Treatment for Opioid Use Disorder (PrIMO)
Other
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
Nashua, New Hampshire • Albuquerque, New Mexico • Salt Lake City, Utah + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Youth Mentoring Program

NCT00158353
View directory record Official record
Conditions
Self Concept
Interventions
GirlPOWER! mentoring program, Traditional mentoring
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
10 Years to 13 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Motivational Interviewing to Reduce Substance Use Among Depression Patients

NCT02420561
View directory record Official record
Conditions
Depression, Substance-Related Disorders
Interventions
Motivational Interviewing, Control (brochure)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
307 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Union City, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa

NCT03529409
View directory record Official record
Conditions
Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use
Interventions
Project Khanya
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

Mindfulness-Based Recovery in Veterans

NCT02326363
View directory record Official record
Conditions
Substance Abuse, Depression, Anxiety Disorder
Interventions
Mindfulness Based Relapse Prevention (MBRP), Twelve-Step Facilitation Intervention (TSF)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Tuscaloosa, Alabama • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Oct 24, 2026, 4:04 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Building Resilience In Caregivers of Trauma Survivors

NCT04293016
View directory record Official record
Conditions
Caregiver Burnout
Interventions
Support as usual, Problem solving therapy, ICU diary
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2024 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

NCT07214467
View directory record Official record
Conditions
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Familias Unidas: Preventing Substance Abuse in Hispanic Youth

NCT01038206
View directory record Official record
Conditions
Prevention, Family Function, Substance Use, Sexual Behavior
Interventions
Familias Unidas
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years and older
Enrollment
746 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional

Treatment for Psychological and Drug Abuse Problems

NCT01140334
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Voucher Reinforcement, Standard Control
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 20, 2013 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia

NCT01549899
View directory record Official record
Conditions
Insomnia
Interventions
In-person Cognitive Behavioral Therapy of Insomnia, Internet Cognitive Behavioral Therapy of Insomnia
Behavioral
Lead sponsor
Daniel J. Taylor, Ph.D.
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional Results available

A Trauma Informed Adaptation of Mindfulness-Based Relapse Prevention for Women in Substance Use Treatment

NCT03505749
View directory record Official record
Conditions
Substance Use Disorders, Post Traumatic Stress Disorder
Interventions
Trauma Informed Mindfulness-Based Relapse Prevention, Treatment As Usual (TAU)
Behavioral
Lead sponsor
Pacific University
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
5
States / cities
Beaverton, Oregon • Hillsboro, Oregon • Mountaindale, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

NCT05619185
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal, Military Family
Interventions
CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook, Gottman Self-Guided Resources
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brain Training for Substance Use Disorders

NCT06870110
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Bias Modification Biofeedback
Device
Lead sponsor
Neurotype Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 24, 2026, 4:04 PM EDT
Completed Not applicable Interventional

CBT for Spanish Speakers

NCT02043210
View directory record Official record
Conditions
Substance Use
Interventions
Standard Treatment as Usual, CBT4CBT plus Standard treatment as usual
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 24, 2026, 4:04 PM EDT
Recruiting Not applicable Interventional

Integrated Treatment for Opioid Use Disorder and PTSD

NCT06641115
View directory record Official record
Conditions
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
HOPE Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 24, 2026, 4:04 PM EDT