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ClinicalTrials.gov public records Last synced Oct 26, 2026, 7:32 AM EDT

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Showing 529–552 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Completed Not applicable Interventional Results available

Preventing Violence Among Veterans in Substance Use Disorder Treatment

NCT01337973
View directory record Official record
Conditions
Aggression, Substance-Related Disorders
Interventions
MI-CBT, MI-CBT+CC, E-TAU
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional

Trauma Intervention for Affect Regulation, AIDS, and Substances

NCT02923141
View directory record Official record
Conditions
Human Immunodeficiency Virus, Substance Related Disorder, Post Traumatic Stress Disorder
Interventions
Neutral Writing, Expressive Writing, Contingency Management
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Oct 26, 2026, 7:32 AM EDT
Recruiting Early Phase 1 Interventional

Psilocybin for Methamphetamine Addiction

NCT06899594
View directory record Official record
Conditions
Methamphetamine Use Disorder
Interventions
Psilocybin 25 mg
Drug
Lead sponsor
Kevin Murnane
Other
Eligibility
25 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 26, 2026, 7:32 AM EDT
Not listed Not applicable Interventional

Study of Ultrasound To Increase Parental Bonding in Women With Substance Use Disorders

NCT02158429
View directory record Official record
Conditions
Substance Use Disorders, Pregnancy
Interventions
2 dimensional vs. 3 dimensional ultrasound
Other
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional

Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness

NCT06074354
View directory record Official record
Conditions
HIV Infections
Interventions
Attention-control group, MY-RIDE group
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 25 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional

Behavioral Depression Treatment for African American HIV-infected Substance Users

NCT01351454
View directory record Official record
Conditions
Depression, Substance Use
Interventions
ACT HEALTHY, Nondirective Therapy (NDT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 7, 2020 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Results available

Varenicline and Motivational Advice for Smokers With Substance Use Disorders

NCT00756275
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 26, 2026, 7:32 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder

NCT07871877
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Withdrawal, Substance Use Disorders
Interventions
Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo, Matching Intramuscular Placebo, My-E-Health SENTINEL Digital Monitoring and Human-Gated Escalation Platform, Standardized Psychological Preparation, Integration and Recovery Support, Garmin-Enabled Longitudinal Wellness Monitoring
Drug · Device · Behavioral + 1 more
Lead sponsor
Clive Michelsen
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Basalt, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional

Trial of a Novel Brief Intervention on Health Behaviors for Youth With Chronic Medical Conditions

NCT02803567
View directory record Official record
Conditions
Substance Use
Interventions
Brief psycho-educational intervention
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
14 Years to 17 Years
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2020 · Synced Oct 26, 2026, 7:32 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Routine Clinical Screening for Substance Use Disorders in the Emergency Room Setting

NCT01661465
View directory record Official record
Conditions
Substance Use
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 85 Years
Enrollment
9,212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Oct 26, 2026, 7:32 AM EDT
Not yet recruiting Not applicable Interventional

Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform

NCT07556861
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Senyo Health App
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The Interactive Media and Gender-related Stressors and Strengths Study

NCT07836907
View directory record Official record
Conditions
Eating Disorders, Substance Use
Interventions
digital web based toolkit
Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 25 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety Awareness For Empowerment (SAFE): An RCT With Young People Experiencing Homelessness

NCT04183400
View directory record Official record
Conditions
Substance Use, Victimization
Interventions
Safety Awareness For Empowerment (SAFE)
Behavioral
Lead sponsor
University of Denver
Other
Eligibility
18 Years to 21 Years
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2020 · Synced Oct 26, 2026, 7:32 AM EDT
Withdrawn Not applicable Interventional

Initiating Substance Use Disorder Treatment for Hospitalized Alcohol Use Disorder Patients

NCT04223011
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
In-Hospital Recovery Coach Intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Oct 26, 2026, 7:32 AM EDT
Not yet recruiting Not applicable Interventional

Preventing Overdose and Promoting Recovery Through Court Navigation

NCT07700407
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
CourtConnect, Information Only
Behavioral · Other
Lead sponsor
RTI International
Other
Eligibility
18 Years to 100 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
South Bend, Indiana • Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Native Spirit: Significant Aim 3: Intervention

NCT06785311
View directory record Official record
Conditions
Substance Use, Self Esteem, Youth Drinking, Prevention, Suicide
Interventions
Native Spirit After-School Program
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
12 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Scottsdale, Arizona • Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Phase 3 Interventional Results available

Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users (PrEPSteps)

NCT03512418
View directory record Official record
Conditions
HIV Infections, Substance Use Disorders
Interventions
PrEPsteps, Digital pill, Truvada
Behavioral · Device · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boylston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Temporal Interference Methods for Addiction Treatment

NCT07210268
View directory record Official record
Conditions
Nicotine Use Disorder, Substance Use Disorders
Interventions
TI-NDBS, Sham TI-NDBS
Device
Lead sponsor
Indiana University
Other
Eligibility
21 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bloomington, Indiana • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Positive Choice: Prevention for Positive Health

NCT00447707
View directory record Official record
Conditions
HIV Infections, Sexual Risk Behavior, Substance Use Risks
Interventions
Positive Choice
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
497 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
5
States / cities
Oakland, California • San Francisco, California • San Leandro, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 26, 2026, 7:32 AM EDT
Completed No phase listed Observational

Consequences of Marijuana Use in HIV-infected Youth

NCT03927053
View directory record Official record
Conditions
Youth With HIV
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
21 Years to 28 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Results available

An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care

NCT04907045
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions
Health Coaching, Practice Facilitation, Standard Implementation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Early Phase 1 Interventional

Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People

NCT06496230
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy Related
Interventions
Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 26, 2026, 7:32 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

NC Young Women's CoOp

NCT02965014
View directory record Official record
Conditions
Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infection (STI), Alcohol and Drug Use
Interventions
Face-to-Face Young Women's CoOp (YWC), mHealth Young Women's CoOp (YWC), HIV Counseling and Testing
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
652 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
4
States / cities
Durham, North Carolina • Greensboro, North Carolina • High Point, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adapting and Evaluating an EBI to Prevent HIV/AIDS Risk Among Apache Youth

NCT01910714
View directory record Official record
Conditions
HIV/AIDS
Interventions
Focus On Youth, Health Education Control Condition
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
13 Years to 19 Years
Enrollment
267 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Oct 26, 2026, 7:32 AM EDT