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ClinicalTrials.gov public records Last synced Oct 28, 2026, 11:12 PM EDT

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Showing 649–672 of 1,104 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

The Men's Domestic Abuse Check-Up Engages Adult Men Concerned About Their Abusive Behavior and Alcohol or Drug Use

NCT01621334
View directory record Official record
Conditions
Domestic Violence, Substance Abuse
Interventions
Motivational Enhancement Therapy, Educational information
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Male only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 18, 2012 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Results available

Pragmatic RCT of SBIRT-PM

NCT04062214
View directory record Official record
Conditions
Substance Use Disorders, Pain
Interventions
SBIRT-PM
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 100 Years
Enrollment
1,101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
9
States / cities
New Haven, Connecticut • West Haven, Connecticut • Augusta, Maine + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Results available

Behavioral Treatment of Adolescent Substance Use

NCT02063984
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Intensive Outpatient Treatment (IOP) + Contingency Management (CM), Working Memory Training
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
12 Years to 26 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 4, 2021 · Synced Oct 28, 2026, 11:12 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Parenting Mindfully Study II

NCT05370768
View directory record Official record
Conditions
Adolescent Substance Use, Adolescent Psychological Symptoms, Parent Stress, Parenting
Interventions
Parenting Mindfully Intervention
Behavioral
Lead sponsor
George Mason University
Other
Eligibility
12 Years to 14 Years
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Not listed Phase 2 Interventional

The Aim of This Study is to Determine the Effectiveness of a Motivational Enhancement Intervention in Reducing Risk Behaviors (Drug and Alcohol Use, Sexual Risk Behavior, Poor Adherence to Medications) Among HIV+ Youth. - 1

NCT00227825
View directory record Official record
Conditions
Adherence, HIV Risk Behaviors, Alcohol & Drug Use, Health Behaviors, Sexual Risk Behaviors
Interventions
Motivational interviewing
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
16 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 28, 2026, 11:12 PM EDT
Active, not recruiting Not applicable Interventional

Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)

NCT04768920
View directory record Official record
Conditions
Substance Use Disorders, Substance Use, Substance Dependence
Interventions
MI-CBT Teletx
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional

A Novel Intervention for Patients With Cancer

NCT05643027
View directory record Official record
Conditions
Substance Use, Cancer, Psychological
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional

Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment

NCT01376570
View directory record Official record
Conditions
HIV, Opiate Dependence
Interventions
Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
3
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Results available

Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1

NCT00249496
View directory record Official record
Conditions
Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
Interventions
Contingency management, Employment Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Novel Prevention Intervention Program to Reduce Risky Patterns of Substance Use Among Emerging Adults

NCT06287203
View directory record Official record
Conditions
Substance Use
Interventions
Addiction Risk Feedback Program
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 25 Years
Enrollment
660 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adolescent Stress and Substance Intervention Subsequent to Trauma

NCT07197476
View directory record Official record
Conditions
PTSD, Substance Use Disorder (SUD), Acute Stress Disorder
Interventions
ASSIST Video Intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
12 Years to 17 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Phase 4 Interventional Results available

Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders

NCT02582905
View directory record Official record
Conditions
Alcohol Use Disorder, Bipolar Disorder, Schizoaffective Disorder Bipolar Type
Interventions
Placebo, Citicoline, Pregnenolone
Drug · Dietary Supplement
Lead sponsor
Sherwood Brown, MD, PhD
Other
Eligibility
18 Years to 70 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
3
States / cities
Miami, Florida • Dallas, Texas • Edinburg, Texas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional

A Brief Intervention for Alcohol Users With Interpersonal Trauma

NCT05414344
View directory record Official record
Conditions
Heavy Drinking, Alcohol Drinking, Substance Use, Drinking Behavior
Interventions
Standard Brief Intervention, Trauma-Informed and Peer-Supported Brief Intervention, Assessment only
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
18 Years to 25 Years
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT

NCT05943171
View directory record Official record
Conditions
Substance Use Disorders, Alcohol Use Disorder, Stimulant-Related Disorder
Interventions
Cognitive Behavioral Therapy, Standard CBT
Device · Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Test of a Cultural Intervention to Enhance Alaska Native Students' Behavioral Health

NCT04561544
View directory record Official record
Conditions
Depression, Anxiety, Suicidal Ideation, Substance Use
Interventions
Knowing Who You Are (Becoming): Cultural Identity Intervention
Behavioral
Lead sponsor
University of Alaska Anchorage
Other
Eligibility
18 Years to 100 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness for at Risk Youth: Understanding Substance Use and Important Mechanisms of Change

NCT04160754
View directory record Official record
Conditions
Alcohol Use, Underage, Alcohol Problem Drinking, Substance Use
Interventions
Mindfulness Based Relapse Prevention, Control (CTL)
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 26 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 28, 2026, 11:12 PM EDT
Recruiting Not applicable Interventional

Calls and Coordination for Transitions of Care at Re-entry

NCT06794983
View directory record Official record
Conditions
Prisoners, Substance Use History, Chronic Medical Conditions, Psychiatric Condition, Substance Use Disorder (SUD)
Interventions
In-person visit with study team member, In-person visit with NCM, Phone calls and texts, Phone calls and texts - NCM
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Positive Choice: Prevention for Positive Health

NCT00447707
View directory record Official record
Conditions
HIV Infections, Sexual Risk Behavior, Substance Use Risks
Interventions
Positive Choice
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
497 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
5
States / cities
Oakland, California • San Francisco, California • San Leandro, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Phase 2 Interventional

Recovery Management Checkups for Women Offenders

NCT01334164
View directory record Official record
Conditions
Recovery Management Checkup (RMC), Outcome Monitoring
Interventions
Recovery Management Checkups, Outcome Monitoring
Behavioral · Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older · Female only
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
2
States / cities
Chicago, Illinois • Normal, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 29, 2015 · Synced Oct 28, 2026, 11:12 PM EDT
Recruiting Not applicable Interventional

Culturally Engaged REcovery: MOms Connected Through Native communitY

NCT06747442
View directory record Official record
Conditions
Substance Use Disorders (SUD), Pregnancy, Maternal Morbidity and Mortality, Cultural Adaptation
Interventions
Cradleboard Journey
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Female only
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Not applicable Interventional

Pre-exposure Prophylaxis (PrEP) Rapid Access

NCT05528562
View directory record Official record
Conditions
Drug Use, Pre-exposure Prophylaxis (PrEP), Opioid Use Disorder
Interventions
PrEP Rapid Access, HIV self-testing, Dried blood spot testing
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Oct 28, 2026, 11:12 PM EDT
Recruiting Not applicable Interventional

tAN for Substance Use Disorder

NCT07281261
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Abuse, Substance Use Disorders, Substance Use Disorders Alcohol Use Withdrawal State
Interventions
Sparrow Ascent, Sparrow Ascent (Sham)
Device
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Phase 2 Interventional Results available

UH3 Varenicline for Cannabis Use Disorder

NCT03980561
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
Varenicline, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Charleston, South Carolina • Pickens, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 28, 2026, 11:12 PM EDT
Completed Phase 2 Interventional

Risk Reduction for Urban Substance Using Men Who Have Sex With Men (MSM)

NCT01327898
View directory record Official record
Conditions
HIV Infection, Substance Abuse
Interventions
empowerment theory-based small group discussion, individual resilience counseling
Behavioral
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
515 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
2
States / cities
Miami Beach, Florida • Wilton Manors, Florida
Source: ClinicalTrials.gov public record
Updated Jul 25, 2014 · Synced Oct 28, 2026, 11:12 PM EDT