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ClinicalTrials.gov public records Last synced Oct 29, 2026, 10:12 AM EDT

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Showing 721–744 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Initiating Substance Use Disorder Treatment for Hospitalized Opioid Use Disorder Patients.

NCT03212794
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Recovery coach
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 26, 2023 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users

NCT04007666
View directory record Official record
Conditions
Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder, PTSD, Recidivism, Depression
Interventions
Cognitive Processing Therapy, Control Group
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
2
States / cities
Osceola, Arkansas • West Memphis, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Adaptive Interventions for Prevention/Intervention for Youth Substance Abuse

NCT03928756
View directory record Official record
Conditions
Substance Use
Interventions
Push Notifications with Tailored Intervention Content, Push Notifications with Engaging, Non-therapeutic Content, No Push Notifications
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
16 Years to 24 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 23, 2019 · Synced Oct 29, 2026, 10:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth

NCT07460973
View directory record Official record
Conditions
Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol)
Interventions
NE+, Control
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
12 Years to 18 Years
Enrollment
843 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1

NCT00158288
View directory record Official record
Conditions
Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence, LAAM, Opioid Dependence, Substance-Related Disorders, Alcohol & Drug Use
Interventions
LAAM
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2001
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Alliances to Disseminate Addiction Prevention and Treatment (ADAPT)

NCT04499079
View directory record Official record
Conditions
Substance-Related Disorders, Recidivism, Opioid-Related Disorders, Substance Use, Criminal Behavior
Interventions
Learning Health System
Other
Lead sponsor
Indiana University
Other
Eligibility
11 Years and older
Enrollment
7,316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Brief New Treatment for Suicide Attempts

NCT03300596
View directory record Official record
Conditions
Suicide, Attempted, Drug Use, Alcohol; Use, Problem
Interventions
Brief intervention to prevent suicide attempt, Enhanced treatment as usual
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Phase II Motivational Interviewing: An Experiential Online Training Tool

NCT02264327
View directory record Official record
Conditions
Substance Use Disorders, Chronic Mental Disorder, HIV/AIDS
Interventions
Motivational Interviewing Simulator (SIM), Motivational Interviewing eBook (eBook), Motivational Interviewing Training (MI Training)
Behavioral
Lead sponsor
Center for Social Innovation, Massachusetts
Other
Eligibility
21 Years to 70 Years
Enrollment
3,816 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Oct 29, 2026, 10:12 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders

NCT06608979
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder, Opioid Use Disorder, Violence, Sexual, Violence, Gender-Based, Violence, Domestic
Interventions
Screening/Referral and Prevention
Behavioral
Lead sponsor
Clemson University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence

NCT02496403
View directory record Official record
Conditions
Opiate Substitution Treatment
Interventions
Standard Medical Management (SMM)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
239 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional Results available

Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD

NCT03681288
View directory record Official record
Conditions
Substance Use Disorder, Post-traumatic Stress Disorder, Moral Injury
Interventions
Mindful Self-Compassion
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Phase 3 Interventional

Motivational Interviewing to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse - 1

NCT00032994
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Behavior Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
422 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
5
States / cities
New York, New York • Eugene, Oregon • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional Results available

Non-Invasive Brain Stimulation and Substance Use

NCT03122587
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Transcranial Alternating Current Stimulation at 10 Hz, Transcranial Alternating Current Stimulation at 40 Hz, Active sham transcranial alternating current stimulation
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 29, 2026, 10:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)

NCT07525258
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol-associated Liver Disease
Interventions
Implementation Intervention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Post-traumatic Stress Disorder (PTSD), Addiction, and Virtual Reality

NCT01186315
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure Therapy, Prolonged Exposure therapy + VR/ER
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 21, 2014 · Synced Oct 29, 2026, 10:12 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking

NCT07264582
View directory record Official record
Conditions
HIV Testing, STI, HCV, Overdose, Drug
Interventions
Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 29, 2026, 10:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

NCT03135886
View directory record Official record
Conditions
HIV/AIDS, Hepatitis C, Substance Use Disorders, Opioid-use Disorder
Interventions
Information Control, HIV and HCV Testing Practice Coaching Intervention, HIV Testing Practice Coaching Intervention
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
418 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 29, 2026, 10:12 AM EDT
Recruiting Not applicable Interventional

A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

NCT06115746
View directory record Official record
Conditions
Substance Use, Harm Reduction, Adolescent Behavior
Interventions
iDECIDE
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
9 Years to 22 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 29, 2026, 10:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Monetary Incentive Delay Task for Probing Reward-related Neural Processes

NCT06369623
View directory record Official record
Conditions
Adolescent Development
Interventions
Monetary Incentive Delay Task
Other
Lead sponsor
Stony Brook University
Other
Eligibility
14 Years to 17 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 29, 2026, 10:12 AM EDT
Recruiting Phase 2 Interventional

Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder

NCT06444256
View directory record Official record
Conditions
Stimulant Use Disorder
Interventions
SUVO, TAU
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 29, 2026, 10:12 AM EDT
Not listed No phase listed Observational

A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder

NCT04419922
View directory record Official record
Conditions
Tobacco Use Disorder, Substance Use Disorders
Interventions
Smartphone Contingency Management Intervention
Behavioral
Lead sponsor
BrightView LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 9, 2020 · Synced Oct 29, 2026, 10:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing SUPPORT, a Community-Driven, Recovery-Oriented System of Care

NCT03132753
View directory record Official record
Conditions
Substance Use
Interventions
SUPPORT
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Oct 29, 2026, 10:12 AM EDT
Not listed Phase 2Phase 3 Interventional

Brief Counseling to Reduce Injuries Among Emergency Department Patients Who Report Alcohol and Substance Use

NCT00547963
View directory record Official record
Conditions
Alcohol Drinking, Marijuana Smoking
Interventions
brief counseling
Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
554 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 8, 2008 · Synced Oct 29, 2026, 10:12 AM EDT
Enrolling by invitation Not applicable Interventional

MIO-CPP to Improve the Well-being, Permanency, and Safety Outcomes for Young Children at Risk of or in Out-of-home Placement in Philadelphia and Bucks Counties, and Affected by Maternal Substance Use

NCT04294134
View directory record Official record
Conditions
Substance Use Disorders, Parent-Child Relations, Parent Child Abuse
Interventions
MIO-CPP, MIO-CPP-CRS
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Female only
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 29, 2026, 10:12 AM EDT