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ClinicalTrials.gov public records Last synced Oct 29, 2026, 2:51 PM EDT

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Showing 769–792 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Completed Not applicable Interventional Results available

Mindfulness-based Intervention to Address PTSD in Trauma-exposed, Homeless Women

NCT04605198
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Depressive Symptoms, Hydrocortisone, Substance Use
Interventions
Modified Mindfulness-based Stress Reduction, Health Promotion Wellness Classes
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Escondido, California • Pomona, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional Results available

First Episode Schizophrenia and Cannabis-Related Disorder Study

NCT00573287
View directory record Official record
Conditions
Cannabis-Related Disorder, Substance-Related Disorders, Schizophrenia, Psychotic Disorders
Interventions
clozapine, risperidone
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
17 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
5
States / cities
Concord, New Hampshire • Lebanon, New Hampshire • Manchester, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Phase 4 Interventional

Facilitating the Adoption of Evidence-Based Depression Management in Substance Use Treatment Programs

NCT00137306
View directory record Official record
Conditions
Mood Disorders, Substance-Related Disorders
Interventions
Facilitate evidence-based treatment for depression
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
5
States / cities
No. Little Rock, Arkansas • New Orleans, Louisiana • Biloxi, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional

Impact of Work Activity on SUD Outcomes

NCT04969081
View directory record Official record
Conditions
Substance-related Disorders
Interventions
referral to work focused program, treatment as usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 29, 2026, 2:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Randomized Trial of a Social Networks Intervention

NCT03059433
View directory record Official record
Conditions
Adolescent Behavior
Interventions
AVID Intervention
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 18 Years
Enrollment
446 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using Aromatherapy in Substance Use Disorder

NCT05660434
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Aroma Inhaler with Bergamot essential oil
Other
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Oct 29, 2026, 2:51 PM EDT
Recruiting Not applicable Interventional

M2VA Pain Care Pathway

NCT06526143
View directory record Official record
Conditions
Pain, Substance Use, Opioid Misuse, Quality of Life
Interventions
M2VA Pain Care Pathway (M2VAPCP), Implementation Facilitation
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

NCT02322047
View directory record Official record
Conditions
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone)
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional

Motivational Interviewing Integrated With Social Network Counseling for Teens

NCT01922947
View directory record Official record
Conditions
Substance Use
Interventions
Motivational Interviewing w/Social Network Counseling, Active Control Condition
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
14 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 29, 2026, 2:51 PM EDT
Recruiting Phase 4 Interventional

Young Houston Emergency Opioid Engagement System

NCT04811014
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use, Substance Use Disorders
Interventions
Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services, Support Group, Referral to Medication Management, Assertive Outreach
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
13 Years to 17 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Oct 29, 2026, 2:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents

NCT05336084
View directory record Official record
Conditions
Sleep
Interventions
Ultradian sleep/wake protocol
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional Results available

Mindfulness-Based Recovery in Veterans

NCT02326363
View directory record Official record
Conditions
Substance Abuse, Depression, Anxiety Disorder
Interventions
Mindfulness Based Relapse Prevention (MBRP), Twelve-Step Facilitation Intervention (TSF)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Tuscaloosa, Alabama • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Phase 4 Interventional Results available

Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

NCT02845453
View directory record Official record
Conditions
Substance Use Disorders, Bipolar Disorder, Mood Disorders
Interventions
Quetiapine, Placebo
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
15 Years to 24 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Phase 1 Interventional

Computer-Based Training in Cognitive Behavior Therapy (CBT4CBT)

NCT01406899
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Computer Based Treatment
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Newington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional

Delivery of Anxiety Disorder Treatment in Addictions Centers

NCT01764698
View directory record Official record
Conditions
Anxiety Disorders, Substance Use Disorders
Interventions
CALM-SUD, Treatment as usual
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Youth to Text or Telehealth for Engagement in HIV Care

NCT03681145
View directory record Official record
Conditions
HIV/AIDS, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Depression, Substance Use
Interventions
Counselor delivered telehealth intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 29 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional

Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

NCT06646692
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Anxiety, Depression - Major Depressive Disorder
Interventions
Mindful Self Compassion, Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 29, 2026, 2:51 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents

NCT05380765
View directory record Official record
Conditions
Alcohol Drinking, Tobacco Use, Drug Use
Interventions
Native PATHS
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
10 Years to 14 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional

Program for Alleviating and Reducing Trauma, Stress, and Substance Use

NCT06207409
View directory record Official record
Conditions
PTSD, Substance Use Disorders
Interventions
PARTS-SUD
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Malden, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Oct 29, 2026, 2:51 PM EDT
Recruiting Not applicable Interventional

Real-time Opioid Study

NCT07768007
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 29, 2026, 2:51 PM EDT
Terminated Not applicable Interventional

Treating Co-Occurring Substance Use and Mental Disorders Among Jail Inmates

NCT02214667
View directory record Official record
Conditions
Co-occurring Mental and Substance Use Disorders, Crime, Criminogenic Thinking, Implementation, Adaptation
Interventions
Dual-diagnosis motivational interviewing (DDMI), Integrated group therapy (IGT), Jail and community-based behavioral health services
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional

Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

NCT00108407
View directory record Official record
Conditions
Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
Interventions
Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2009 · Synced Oct 29, 2026, 2:51 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Routine Clinical Screening for Substance Use Disorders in the Emergency Room Setting

NCT01661465
View directory record Official record
Conditions
Substance Use
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 85 Years
Enrollment
9,212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Oct 29, 2026, 2:51 PM EDT
Completed Not applicable Interventional Results available

Data-driven Identification for Substance Misuse

NCT03833804
View directory record Official record
Conditions
Substance Use, Substance Abuse, Substance-Related Disorders
Interventions
Processing of clinical notes in the EHR data collected during routine care
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 89 Years
Enrollment
64,996 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 29, 2026, 2:51 PM EDT