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ClinicalTrials.gov public records Last synced Oct 29, 2026, 6:36 PM EDT

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Showing 817–840 of 1,105 matching trials from the live ClinicalTrials.gov search.
Conditions
Alcohol Use Disorder (AUD), Substance Use Disorders
Interventions
W-SUDs, Digitally-delivered Psychoeducation
Device · Other
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 65 Years
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Completed Not applicable Interventional Results available

The Therapeutic Workplace Initiation Study

NCT00249470
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
Interventions
Abstinence & Work, Work Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Alcohol Abuse, Posttraumatic Stress Disorder
Interventions
Prazosin, Placebo medication
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Not yet recruiting Not applicable Interventional

Homeless Overdose Prevention- Expansion

NCT07716202
Conditions
Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
Interventions
Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Palo Alto, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder

NCT05872386
Conditions
Telehealth at the Library, Control Group
Interventions
Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Diego, California
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

BrotherlyACT: A Tech-Enhanced Violence and Substance Use Intervention for Black Boys and Young Men

NCT06359990
Conditions
Violence in Adolescence, Substance Use, Avoidance of Healthcare
Interventions
BrotherlyACT, BrotherlyACT Waitlist Control Group (WCG)
Behavioral · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
15 Years to 24 Years · Male only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Delayed Sleep Phase Syndrome
Interventions
Increase morning bright light, Decrease evening blue light, Sleep Scheduling, Monitor sleep, mood, and substance use
Other · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 15 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Co-Occurring Disorders, Homelessness, Substance Abuse Disorder, Mental Illness
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Bedford, Massachusetts
Conditions
Relationship, Family, Substance Use, Parenting
Interventions
Within My Reach/ Within Our Reach
Behavioral
Lead sponsor
Phoenix House Foundation, Inc.
Other
Eligibility
Not listed
Enrollment
3,825 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
3
States / cities
Hauppauge, New York • Long Island City, New York • Ronkonkoma, New York
Conditions
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Interventions
PT150, Beverage
Drug · Other
Lead sponsor
Pop Test Oncology LLC
Industry
Eligibility
21 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Houston, Texas
Conditions
Substance Use Disorder
Interventions
Mothering from the Inside Out
Behavioral
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Springfield, Massachusetts
Conditions
Internalizing Disorders, Substance Use Disorders
Interventions
Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
Behavioral
Lead sponsor
The National Center on Addiction and Substance Abuse at Columbia University
Other
Eligibility
13 Years to 21 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Jacksonville, Florida • Chicago, Illinois • Indianapolis, Indiana + 1 more
Recruiting Phase 2 Interventional

Endocannabinoids in Reward

NCT07815691
Conditions
Cannabis Use Disorder
Interventions
Dronabinol, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 45 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Charleston, South Carolina
Recruiting Phase 2 Interventional Accepts healthy volunteers

Parenting in 2 Worlds Multisite Trial

NCT06324318
Conditions
Parenting, Mental Health Wellness 1, Substance Use, Risky Health Behavior
Interventions
Parenting in 2 Worlds (P2W), Healthy Families in 2 Worlds (HF2W)
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
12 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
4
States / cities
Phoenix, Arizona • Denver, Colorado • Saint Paul, Minnesota + 1 more
Conditions
Substance Use, HIV/AIDS
Interventions
TIPS app, Trauma Focused-Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 18 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Conditions
Perinatal Depression, Substance Use
Interventions
Sober Network Interpersonal Psychotherapy (IPT), Treatment as Usual
Behavioral · Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Completed Not applicable Interventional Results available

Pragmatic RCT of SBIRT-PM

NCT04062214
Conditions
Substance Use Disorders, Pain
Interventions
SBIRT-PM
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 100 Years
Enrollment
1,101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
9
States / cities
New Haven, Connecticut • West Haven, Connecticut • Augusta, Maine + 6 more
Conditions
Gram-Positive Bacterial Infections, Gram-Positive Bacteraemia, Substance Use Disorders, Intravenous Substance Abuse
Interventions
Dalbavancin
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Conditions
Alcohol Dependence, Alcoholism, Drug Dependence
Interventions
Chronic Disease Management for substance abuse, Standard care
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
569 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Heavy Drinking, Alcohol Drinking, Substance Use, Drinking Behavior
Interventions
Standard Brief Intervention, Trauma-Informed and Peer-Supported Brief Intervention, Assessment only
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
18 Years to 25 Years
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Completed Early Phase 1 Interventional Accepts healthy volunteers

Smoking Cessation for Young Adults Who Binge Drink - 1

NCT00218452
Conditions
Adherence, Tobacco Use Cessation, Alcohol & Drug Use, Nicotine Transdermal System
Interventions
Lifestyle counseling
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 25 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
3
States / cities
Jacksonville, Florida • Rochester, Minnesota
Active, not recruiting Not applicable Interventional

Supportive Release Center Study

NCT03616990
Conditions
Mental Health, Mental Health Services, Substance Use, Continuity of Patient Care, Recidivism
Interventions
TASC Service Linkages - Discharge Area Only, SRC Overnight Stay, TASC Services Linkages - SRC Onsite, APN Appointment
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Male only
Enrollment
15,195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Recruiting Phase 4 Interventional Accepts healthy volunteers

ANCHORS Alcohol & Sexual Health Study: UH3 Project

NCT04331704
Conditions
Alcohol Use, Unspecified, Substance Use, Sex Behavior
Interventions
PrEP acronym (pre-exposure prophylaxis), Initial Web Survey, Interactive Voice Response (IVR) monitoring, Educational material on alcohol and sexual health behavior, Interactive Voice Response (IVR) assessment with personalized information, Personalized information based on web-based survey responses & standardized information
Drug · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Suicide, Suicidal Ideation, Substance-Related Disorders
Interventions
Cognitive Behavioral Therapy (CBT), Supportive Psycho-education (SPC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
3
States / cities
Colorado Springs, Colorado • Denver, Colorado • Ann Arbor, Michigan