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ClinicalTrials.gov public records Last synced Oct 31, 2026, 1:29 PM EDT

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Showing 865–888 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Completed Phase 3 Interventional Results available

Insomnia and Drug Relapse Risk

NCT00253890
View directory record Official record
Conditions
Poor Quality Sleep, Opiate Addiction
Interventions
Trazodone, Placebo
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 11, 2013 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Phase 3 Interventional

Addiction Health Evaluation And Disease Management (AHEAD) Study

NCT00278447
View directory record Official record
Conditions
Alcohol Dependence, Alcoholism, Drug Dependence
Interventions
Chronic Disease Management for substance abuse, Standard care
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
569 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2014 · Synced Oct 31, 2026, 1:29 PM EDT
Active, not recruiting Not applicable Interventional

Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use

NCT06682468
View directory record Official record
Conditions
Substance Use Disorders, HIV
Interventions
Population level patient portal based substance involvement screening, Usual Care Substance Use Involvement Screening
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brain Training for Substance Use Disorders

NCT06870110
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Bias Modification Biofeedback
Device
Lead sponsor
Neurotype Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Hybrid Effectiveness Implementation Study of Latino/a Alcohol and Drug Users

NCT04771650
View directory record Official record
Conditions
Alcohol Use Disorder, Drug Use, Psychological Distress
Interventions
CAMI
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 65 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts • Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional

Screening, Brief Intervention, and Referral to Treatment for Offenders

NCT01683643
View directory record Official record
Conditions
Substance Use, HIV Infections
Interventions
SBIRT, Control Group
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 100 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Alcohol Screening in an Ethnically Diverse Sample of Adolescents in Primary Care

NCT01797835
View directory record Official record
Conditions
Alcohol Use, Drug Use
Interventions
CHAT brief MI intervention, usual care
Behavioral
Lead sponsor
RAND
Other
Eligibility
12 Years to 18 Years
Enrollment
294 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
2
States / cities
North Hollywood, California • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Oct 31, 2026, 1:29 PM EDT
Recruiting Not applicable Interventional

Testing and Evaluation of the Returning to the Land Intervention to Address and Prevent Substance Misuse

NCT07695818
View directory record Official record
Conditions
Substance Use, Children, Cultural Factors
Interventions
Returning to the Land - Biodiverse Outdoor Setting, Control
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
14 Years to 19 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Box Elder, Montana
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Delivery of Parenting Support Within a Peer Recovery Support Service Model

NCT07743359
View directory record Official record
Conditions
Substance Use Disorders (SUDs)
Interventions
Relational Health Enhanced Parenting Support (RHEP) implementation bundle, First Steps Together
Other · Behavioral
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older
Enrollment
288 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healing Lodge First Face Training Evaluation Study

NCT06290180
View directory record Official record
Conditions
Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
Interventions
First Face for Mental Heatlh
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Spokane Valley, Washington
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 31, 2026, 1:29 PM EDT
Terminated Phase 2 Interventional Results available

Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD

NCT04316559
View directory record Official record
Conditions
Opioid-Use Disorder
Interventions
Placebo, TRV734, Oxycodone
Other · Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

Research Investigating Drug Effects-2 (RiDE-2)

NCT06758596
View directory record Official record
Conditions
Cannabis Use, Substance Use Disorder (SUD), Healthy
Interventions
Placebo Oral Capsule, THC
Drug
Lead sponsor
University of Illinois Chicago
Other
Eligibility
18 Years to 21 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2031
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional

EMA of Substance Use in Homeless Youth

NCT04884087
View directory record Official record
Conditions
Substance Use
Interventions
Ecological Momentary Assessment (EMA; Metricwire) Prompts 3x/day, Ecological Momentary Assessment (EMA; Metricwire) Prompts 6x/day, Incentive Structure - fixed, Incentive Structure - prize based
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
18 Years to 24 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 17, 2023 · Synced Oct 31, 2026, 1:29 PM EDT
Active, not recruiting Phase 2 Interventional

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2

NCT06006143
View directory record Official record
Conditions
Alcohol Use Disorder, Hiv, Tobacco Use Disorder
Interventions
Varenicline
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Not yet recruiting Not applicable Interventional

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

NCT07409350
View directory record Official record
Conditions
Substance Use, HIV Prevention
Interventions
LINKED, Group Intervention
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
3
States / cities
Los Angeles, California • Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2020 · Synced Oct 31, 2026, 1:29 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder

NCT07871877
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Withdrawal, Substance Use Disorders
Interventions
Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo, Matching Intramuscular Placebo, My-E-Health SENTINEL Digital Monitoring and Human-Gated Escalation Platform, Standardized Psychological Preparation, Integration and Recovery Support, Garmin-Enabled Longitudinal Wellness Monitoring
Drug · Device · Behavioral + 1 more
Lead sponsor
Clive Michelsen
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Basalt, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 31, 2026, 1:29 PM EDT
Withdrawn Not applicable Interventional

State and Trait Mediated Response to TMS in Substance Use Disorder

NCT03707600
View directory record Official record
Conditions
Nicotine Dependence
Interventions
TMS
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Phase 1Phase 2 Interventional

Developing Violence Prevention Therapy for Substance Abusers

NCT00551863
View directory record Official record
Conditions
Substance Use Disorders, Violence
Interventions
IVPT
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 7, 2015 · Synced Oct 31, 2026, 1:29 PM EDT
Completed No phase listed Observational

Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study

NCT03414411
View directory record Official record
Conditions
HIV Infections, Alcohol Drinking, Substance-Related Disorders, Bone Diseases, Falls Injury, Fractures, Bone, Injuries
Interventions
Not listed
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Organization-level Youth Engagement Approach for Substance Misuse Prevention

NCT05736211
View directory record Official record
Conditions
Drug Use, Substance Use, Opioid Use, Substance Misuse
Interventions
Organization-level Youth Engagement prevention strategy
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 31, 2026, 1:29 PM EDT
Recruiting Not applicable Interventional

Utilizing Battlefield Acupuncture to Treat Chronic Pain

NCT06128772
View directory record Official record
Conditions
Chronic Pain, Substance Use Disorders
Interventions
Battlefield Acupuncture
Other
Lead sponsor
Edith Nourse Rogers Memorial Veterans Hospital
Federal
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Oct 31, 2026, 1:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Quality in Protective Strategies

NCT04978129
View directory record Official record
Conditions
Health Risk Behaviors, Risk Reduction Behavior
Interventions
Online and Text Messaging Intervention
Behavioral
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
18 Years to 24 Years
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 31, 2026, 1:29 PM EDT
Active, not recruiting Not applicable Interventional

Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)

NCT06116266
View directory record Official record
Conditions
Substance Use
Interventions
Education and support for primary care providers (PCPS), Nurse Care Manager (NCM) visits, Addiction specialist consultant, Health coaching sessions, Patient educational materials
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
8
States / cities
Torrance, California • New York, New York • Enterprise, Oregon + 4 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 31, 2026, 1:29 PM EDT