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ClinicalTrials.gov public records Last synced Nov 1, 2026, 1:11 AM EST

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1009–1032 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Withdrawn Phase 2 Interventional

Development of a Selective ALDH2 Inhibitor to Treat AUD

NCT04311294
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
ANS-6637 Low Dose, ANS-6637 High Dose, Matched Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Nov 1, 2026, 1:11 AM EST
Terminated No phase listed Observational Accepts healthy volunteers

Routine Clinical Screening for Substance Use Disorders in the Emergency Room Setting

NCT01661465
View directory record Official record
Conditions
Substance Use
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 85 Years
Enrollment
9,212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional

Exercise: Addressing Stress in Relapse Prevention for Substance Use Disorders

NCT01828307
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Motivational enhancement therapy (MET), Contingency management, Standard Aftercare Treatment
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Nov 1, 2026, 1:11 AM EST
Completed Phase 2 Interventional

Alcohol Use Disorders (AUDs) and Post-traumatic Stress Disorder (PTSD) Treatment for Victims of Partner Violence

NCT00607412
View directory record Official record
Conditions
PTSD, Substance Use Disorders
Interventions
Integrated psychotherapy for PTSD and substance use, 12-step based supportive therapy
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 11, 2011 · Synced Nov 1, 2026, 1:11 AM EST
Completed Phase 2 Interventional Results available

UH3 Varenicline for Cannabis Use Disorder

NCT03980561
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
Varenicline, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Charleston, South Carolina • Pickens, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Nov 1, 2026, 1:11 AM EST
Completed Phase 3 Interventional Results available

Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)

NCT00671853
View directory record Official record
Conditions
Bipolar Disorder, Anxiety, Anxiety Disorders, Substance Use Disorders
Interventions
Quetiapine XR, Placebo for quetiapine XR
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 29, 2016 · Synced Nov 1, 2026, 1:11 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Orexin s Role in the Neurobiology of Substance Use Disorder

NCT05630781
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Belsomra, Placebo, Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Terminated Not applicable Interventional Results available

Reward-based Technology to Improve OUD Treatment

NCT05180669
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
OARSCM Software Application, MyMAT Software Application
Other
Lead sponsor
Q2i, LLC
Industry
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Completed Phase 1 Interventional

Computer-Based Training in Cognitive Behavior Therapy (CBT4CBT)

NCT01406899
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Computer Based Treatment
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Newington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Nov 1, 2026, 1:11 AM EST
Not yet recruiting Not applicable Interventional

A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults

NCT07214831
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Large language model-based chatbot brief alcohol intervention session
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 29 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Nov 1, 2026, 1:11 AM EST
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

NCT07460622
View directory record Official record
Conditions
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Interventions
Virtual Reality E-Cigarette Prevention Program
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Texas Family Health Patterns: A Study Across Generations

NCT02438254
View directory record Official record
Conditions
Alcohol and Other Drug Use Disorders
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 30 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Stepped Care for Youth Living With HIV

NCT03109431
View directory record Official record
Conditions
HIV, Mental Health, Illicit Substance Use, Sexually Transmitted Infections (STI)
Interventions
Level 1, Level 2, Level 3
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 24 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
2
States / cities
Los Angeles, California • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional Results available

Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment

NCT02648022
View directory record Official record
Conditions
Hepatitis C, Depression, PTSD, Substance Use Disorder, Fibrosis
Interventions
Brief mental health interventions and case management
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 20, 2016 · Synced Nov 1, 2026, 1:11 AM EST
Not listed Not applicable Interventional Accepts healthy volunteers

Designing a Mobile App for Veterans With Substance Use Problems

NCT01812187
View directory record Official record
Conditions
Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
Interventions
SHIFT Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Michael E. DeBakey VA Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2015 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional Results available

Individual and Family Motivational Interviews for Substance Using Truant Teens

NCT01170026
View directory record Official record
Conditions
Substance Use
Interventions
Family Check-up/ Individual MI, Individual and family psychoeducation
Behavioral
Lead sponsor
Brown University
Other
Eligibility
13 Years to 16 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional

Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders

NCT07737652
View directory record Official record
Conditions
Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
Interventions
Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder
Device · Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Completed Phase 3 Interventional

Integrated Cognitive Behavioral Therapy (ICBT) for Posttraumatic Stress Disorder (PTSD) and Substance Use Disorders

NCT01457404
View directory record Official record
Conditions
Stress Disorder, Post-Traumatic, Substance-Related Disorders
Interventions
Integrated Cognitive Behavioral Therapy, Treatment-as-usual
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 26, 2015 · Synced Nov 1, 2026, 1:11 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Linking Individuals Needing Care for Substance Use Disorders to Peer Coaches & Across INcarceration Settings

NCT07563517
View directory record Official record
Conditions
Substance Use
Interventions
Virtual Peer Recovery Coaching, Treatment as Usual
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
3
States / cities
Atlanta, Georgia • Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional

rTMS as Add on Treatment for Substance Use Disorders

NCT06963476
View directory record Official record
Conditions
Opioid Use, Alcohol Use Disorder
Interventions
repetitive transcranial magnetic stimulation (rTMS) for AUD, repetitive transcranial magnetic stimulation (rTMS) for OUD
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use

NCT02951455
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Critical Dialogue, Capacity Building Project, Quality of Life Wheel, PF, LC
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older · Male only
Enrollment
602 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 23, 2022 · Synced Nov 1, 2026, 1:11 AM EST
Recruiting Not applicable Interventional

Brief Motivational Interviewing +/- Mindfulness Training for Adolescent Alcohol Use in Pediatric Primary Care

NCT07059078
View directory record Official record
Conditions
Adolescent Alcohol Use
Interventions
Brief Motivational Interviewing-based Alcohol Intervention, Smartphone App-delivered Mindfulness Training
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 17 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
13
States / cities
Baltimore, Maryland • Belcamp, Maryland • Bowie, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Nov 1, 2026, 1:11 AM EST
Completed Not applicable Interventional

Behavioral Depression Treatment for African American HIV-infected Substance Users

NCT01351454
View directory record Official record
Conditions
Depression, Substance Use
Interventions
ACT HEALTHY, Nondirective Therapy (NDT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Washington D.C., District of Columbia • College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 7, 2020 · Synced Nov 1, 2026, 1:11 AM EST
Not listed No phase listed Observational

A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder

NCT04419922
View directory record Official record
Conditions
Tobacco Use Disorder, Substance Use Disorders
Interventions
Smartphone Contingency Management Intervention
Behavioral
Lead sponsor
BrightView LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 9, 2020 · Synced Nov 1, 2026, 1:11 AM EST