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ClinicalTrials.gov public records Last synced Nov 1, 2026, 5:16 AM EST

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Showing 1057–1080 of 1,105 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol & Drug Use Clear all
Enrolling by invitation Not applicable Interventional

Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

NCT07527871
View directory record Official record
Conditions
Substance Use (Drugs, Alcohol)
Interventions
ED-SMART intervention, Substance use information
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional

Family Intervention for Mental Illness and Substance Abuse

NCT00043693
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Substance-related Disorders
Interventions
Family Intervention for Dual Diagnosis, Family psychoeducation program
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
2
States / cities
Santa Fe Springs, California • Chelsea, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 8, 2012 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Results available

Mindfulness-Based Recovery in Veterans

NCT02326363
View directory record Official record
Conditions
Substance Abuse, Depression, Anxiety Disorder
Interventions
Mindfulness Based Relapse Prevention (MBRP), Twelve-Step Facilitation Intervention (TSF)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Tuscaloosa, Alabama • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Nov 1, 2026, 5:16 AM EST
Not listed No phase listed Observational Accepts healthy volunteers

Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users

NCT02945293
View directory record Official record
Conditions
Mild to Heavy Alcohol Consumption
Interventions
Oxycodone
Other
Lead sponsor
University of Washington
Other
Eligibility
35 Years and older
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes

NCT04637581
View directory record Official record
Conditions
Substance-Related Disorders, Depression, Stress Disorders, Post-Traumatic, Child Abuse, Child Neglect
Interventions
Wraparound
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
4
States / cities
Claremont, New Hampshire • Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intervention for Battered Sheltered Women With Substance Use Randomized Trial

NCT02629133
View directory record Official record
Conditions
Intimate Partner Violence
Interventions
SHE Program
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
4
States / cities
Attleboro, Massachusetts • Akron, Ohio • Providence, Rhode Island + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2020 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Results available

Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD

NCT06262347
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse, Drug Abuse in Pregnancy, Drug Addiction
Interventions
Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
Behavioral
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
6
States / cities
Jacksonville, Florida • Pittsburgh, Pennsylvania • Charleston, South Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Computerized Screening, Brief Intervention, and Referral to Treatment in Primary Care

NCT01003834
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Computerized brief intervention, Computerized health screening, Computerized assessment, Therapist-delivered motivational intervention
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
713 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2015 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional

Improving Sleep to Reduce Risk for Substance Use Disorder

NCT03226132
View directory record Official record
Conditions
Substance Use Disorders, Insomnia, Posttraumatic Stress Disorder
Interventions
Brief Behavioral Therapy for Insomnia, Repeated Contact
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 30 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional

Program for Alleviating and Reducing Trauma, Stress, and Substance Use

NCT06207409
View directory record Official record
Conditions
PTSD, Substance Use Disorders
Interventions
PARTS-SUD
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Malden, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Results available

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

NCT05471921
View directory record Official record
Conditions
Alcohol and Substance-Related Mental Disorders
Interventions
SBIRT, Treatment as usual
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Nov 1, 2026, 5:16 AM EST
Terminated Phase 4 Interventional Results available

Emergency Department Initiated Extended-Release Naltrexone and Case Management for the Treatment of Alcohol Use Disorder

NCT04094584
View directory record Official record
Conditions
Alcohol Use Disorder, Substance Use, Alcohol Abuse or Dependence
Interventions
Vivitrol (Extended Release Naltrexone)
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Nov 1, 2026, 5:16 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

A Regional Partnership to Improve Outcomes Through Fatherhood Engagement

NCT05562557
View directory record Official record
Conditions
Substance Use, Child Abuse, Child Neglect, Fathers, Father-Child Relations
Interventions
Motivational Enhancement, HERO Dads Fatherhood Program, Contingency Management, Case Management
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Male only
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Results available

Three Strategies for Implementing Motivational Interviewing on Medical Inpatient Units

NCT01825057
View directory record Official record
Conditions
See One, Do One, Order One
Interventions
See One, Do One, Order One
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 100 Years
Enrollment
1,211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional

RETAIN: Retaining Opioid Users Entering Medication Assisted Treatment and Encouraging HCV/HIV Testing

NCT03411265
View directory record Official record
Conditions
Opioid-Related Disorders, Opioid-use Disorder, Drug Addiction, Substance Use Disorders
Interventions
self-administered, e-health application
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Nov 1, 2026, 5:16 AM EST
Completed No phase listed Observational Results available

Strategies to Enhance Recruitment and Retention of Black Individuals Into Clinical Trials for Substance Use Disorders

NCT05124119
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
63 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Nov 1, 2026, 5:16 AM EST
Completed Phase 3 Interventional

Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics - 1

NCT00033007
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Behavior Therapy
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 99 Years
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2003
U.S. locations
11
States / cities
Los Angeles, California • Alamosa, Colorado • Littleton, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Dual Use Approach Bias Training for Nicotine Addiction

NCT05306158
View directory record Official record
Conditions
Tobacco Smoking, Electronic Cigarette Use, Substance Use
Interventions
CC+ECIG Condition, CC Condition, Sham Condition
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Nov 1, 2026, 5:16 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Family Risk Analysis of Substance Use in Attention Deficit Hyperactivity Disorder (ADHD) Youth Treated With Concerta

NCT00181792
View directory record Official record
Conditions
ADHD, Smoking
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
6 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 4, 2012 · Synced Nov 1, 2026, 5:16 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

NCT04197921
View directory record Official record
Conditions
Opioid-use Disorder, Substance Use Disorders
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
4
States / cities
Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional Results available

Providing Expanded Continuous Labor Support to Pregnant Women in New Mexico With Substance Use Disorders

NCT03808909
View directory record Official record
Conditions
Pregnancy Related, Substance Use Disorders
Interventions
Continuous Labor Support
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Nov 1, 2026, 5:16 AM EST
Completed Not applicable Interventional

Developing an Intervention to Address Suicide Risk During Substance Use Disorder

NCT01127932
View directory record Official record
Conditions
Suicide, Substance-Related Disorders
Interventions
Psychoeducation for substance abuse, CBT for suicide in Substance abuse
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Waterford, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Nov 1, 2026, 5:16 AM EST
Completed No phase listed Observational

Improving Adolescent Health Outcomes Through Preventive Care Transformation

NCT02244138
View directory record Official record
Conditions
Sexually Transmitted Diseases, Depression Diagnosis, Substance Use Disorders
Interventions
Adolescent CDSS
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
12 Years to 21 Years
Enrollment
2,831 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 9, 2018 · Synced Nov 1, 2026, 5:16 AM EST
Completed Phase 2 Interventional Results available

SMART Trial: Intrapersonal and Interpersonal Stigma Reduction

NCT04693416
View directory record Official record
Conditions
Stigma, Social, Opioid Use, Opioid-use Disorder, Substance Use Disorders
Interventions
Intrapersonal Stigma Reduction, Interpersonal Stigma Reduction
Other
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Nov 1, 2026, 5:16 AM EST